The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6
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Title
The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6
Authors
Keywords
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Journal
BIOCHEMICAL JOURNAL
Volume 477, Issue 2, Pages 541-555
Publisher
Portland Press Ltd.
Online
2020-01-09
DOI
10.1042/bcj20190647
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Note: Only part of the references are listed.- Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally
- (2020) Isabelle M. Capell-Hattam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase
- (2019) Ngee Kiat Chua et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates
- (2018) Edmond Y. Huang et al. MOLECULAR BIOLOGY OF THE CELL
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- (2018) Phillip A. Wages et al. JOURNAL OF LIPID RESEARCH
- Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD
- (2018) Mark L. Schultz et al. Nature Communications
- N-terminal acetylation and the N-end rule pathway control degradation of the lipid droplet protein PLIN2
- (2018) Kha The Nguyen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cholesterol increases protein levels of the E3 ligase MARCH6, and thereby stimulates protein degradation
- (2018) Laura J. Sharpe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1
- (2018) Sam A Menzies et al. eLife
- Role of CYP51 in the Regulation of T3 and FSH-Induced Steroidogenesis in Female Mice
- (2017) Juan Liu et al. ENDOCRINOLOGY
- A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis
- (2017) Ngee Kiat Chua et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis
- (2017) Anika V. Prabhu et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation
- (2017) Yong-Jian Wang et al. NATURE CELL BIOLOGY
- The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy
- (2017) Yong Tae Kwon et al. TRENDS IN BIOCHEMICAL SCIENCES
- Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages
- (2017) Elisa Araldi et al. Cell Reports
- The Role of Cholesterol in Cancer
- (2016) Omer F. Kuzu et al. CANCER RESEARCH
- Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame
- (2016) Sung-Mi Kim et al. DRUG METABOLISM REVIEWS
- Novel phenotypes and loci identified through clinical genomics approaches to pediatric cataract
- (2016) Nisha Patel et al. HUMAN GENETICS
- Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis
- (2016) Anika V. Prabhu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Next-generation Sequencing in the Diagnosis of Metabolic Disease Marked by Pediatric Cataract
- (2016) Rachel L. Gillespie et al. OPHTHALMOLOGY
- DHCR7: A vital enzyme switch between cholesterol and vitamin D production
- (2016) Anika V. Prabhu et al. PROGRESS IN LIPID RESEARCH
- The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change
- (2015) Vicky Howe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally
- (2015) Winnie Luu et al. JOURNAL OF LIPID RESEARCH
- A MARCH6 and IDOL E3 ubiquitin ligase circuit uncouples cholesterol synthesis from lipoprotein uptake in hepatocytes
- (2015) Anke Loregger et al. MOLECULAR AND CELLULAR BIOLOGY
- Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways
- (2015) Matthew A Mitsche et al. eLife
- Contribution of Clinically Derived Mutations inERG11to Azole Resistance in Candida albicans
- (2014) Stephanie A. Flowers et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids
- (2014) Julian Stevenson et al. BIOCHEMICAL JOURNAL
- The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis
- (2014) Anika V. Prabhu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Cholesterol in brain disease: sometimes determinant and frequently implicated
- (2014) M. G. Martin et al. EMBO REPORTS
- The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway
- (2014) N. Zelcer et al. MOLECULAR AND CELLULAR BIOLOGY
- Personalized Diagnosis and Management of Congenital Cataract by Next-Generation Sequencing
- (2014) Rachel L. Gillespie et al. OPHTHALMOLOGY
- Quality control of inner nuclear membrane proteins by the Asi complex
- (2014) O. Foresti et al. SCIENCE
- Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis
- (2013) Winnie Luu et al. JOURNAL OF LIPID RESEARCH
- FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter
- (2013) Jun Zhu et al. JOURNAL OF LIPID RESEARCH
- Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis
- (2013) Eser J. Zerenturk et al. PROGRESS IN LIPID RESEARCH
- Nitric oxide-based protein modification: formation and site-specificity of protein S-nitrosylation
- (2013) Izabella Kovacs et al. Frontiers in Plant Science
- The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)
- (2011) Eser J. Zerenturk et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Akt acutely activates the cholesterogenic transcription factor SREBP-2
- (2011) Winnie Luu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase
- (2011) Saloni Gill et al. Cell Metabolism
- A Meta-Analysis of Low-Density Lipoprotein Cholesterol, Non-High-Density Lipoprotein Cholesterol, and Apolipoprotein B as Markers of Cardiovascular Risk
- (2011) Allan D. Sniderman et al.
- Cytochrome P450s in the synthesis of cholesterol and bile acids - from mouse models to human diseases
- (2011) Gregor Lorbek et al. FEBS Journal
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- (2011) Rok Keber et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of HMG-CoA reductase in mammals and yeast
- (2011) John S. Burg et al. PROGRESS IN LIPID RESEARCH
- Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase
- (2010) Youngah Jo et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Malformation syndromes caused by disorders of cholesterol synthesis
- (2010) Forbes D. Porter et al. JOURNAL OF LIPID RESEARCH
- Dual Mechanisms of CYP3A Protein Regulation by Proinflammatory Cytokine Stimulation in Primary Hepatocyte Cultures
- (2009) C.-M. Lee et al. DRUG METABOLISM AND DISPOSITION
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- Regulation of Cholesterologenesis by the Oxysterol Receptor, LXRα
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- Mode of Action of Fenarimol Against Leishmania Spp.
- (2008) Einat Zeiman et al. JOURNAL OF PARASITOLOGY
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