A Conserved C-terminal Element in the Yeast Doa10 and Human MARCH6 Ubiquitin Ligases Required for Selective Substrate Degradation

The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron

(2015) Gregor Habeck et al.   JOURNAL OF CELL BIOLOGY

STUbL-mediated degradation of the transcription factor MATα2 requires degradation elements that coincide with corepressor binding sites

(2015) Christopher M. Hickey et al.   MOLECULAR BIOLOGY OF THE CELL

Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway

(2015) S.-E. Park et al.   SCIENCE

Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope

(2014) Dimitrios Zattas et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway

(2014) N. Zelcer et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein quality control at the inner nuclear membrane

(2014) Anton Khmelinskii et al.   NATURE

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I

(2014) D. J. H. van den Boomen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quality control of inner nuclear membrane proteins by the Asi complex

(2014) O. Foresti et al.   SCIENCE

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

(2014) Michael L. van de Weijer et al.   Nature Communications

RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

(2013) Meredith B. Metzger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Placing a Disrupted Degradation Motif at the C Terminus of Proteasome Substrates Attenuates Degradation without Impairing Ubiquitylation

(2013) Omri S. Alfassy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequential Duplications of an Ancient Member of the DnaJ-Family Expanded the Functional Chaperone Network in the Eukaryotic Cytosol

(2013) Chandan Sahi et al.   MOLECULAR BIOLOGY AND EVOLUTION

N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates

(2013) Dimitrios Zattas et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting

(2013) Ayala Shiber et al.   MOLECULAR BIOLOGY OF THE CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

(2013) Ombretta Foresti et al.   eLife

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase

(2012) Eric M. Rubenstein et al.   JOURNAL OF CELL BIOLOGY

STT3B-Dependent Posttranslational N-Glycosylation as a Surveillance System for Secretory Protein

(2012) Takashi Sato et al.   MOLECULAR CELL

Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

(2011) P de Bie et al.   CELL DEATH AND DIFFERENTIATION

An Unusual Transmembrane Helix in the Endoplasmic Reticulum Ubiquitin Ligase Doa10 Modulates Degradation of Its Cognate E2 Enzyme

(2011) Stefan G. Kreft et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exposure of bipartite hydrophobic signal triggers nuclear quality control of Ndc10 at the endoplasmic reticulum/nuclear envelope

(2011) Noa Furth et al.   MOLECULAR BIOLOGY OF THE CELL

High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases

(2011) Fuqiang Chen et al.   NATURE METHODS

HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation

(2011) Marian L. Burr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradation of a Cytosolic Protein Requires Endoplasmic Reticulum-associated Degradation Machinery

(2008) Meredith Boyle Metzger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diversity of degradation signals in the ubiquitin–proteasome system

(2008) Tommer Ravid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Recognition and Retrotranslocation of Misfolded Proteins from the Endoplasmic Reticulum

(2008) Kunio Nakatsukasa et al.   TRAFFIC