Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally

The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6

(2020) Nicola A. Scott et al.   BIOCHEMICAL JOURNAL

Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase

(2019) Ngee Kiat Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron

(2019) Ngee Kiat Chua et al.   BIOCHEMICAL JOURNAL

Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing

(2019) Liang Chen et al.   JOURNAL OF LIPID RESEARCH

Characterisation of the interaction between arginine methyltransferase Hmt1 and its substrate Npl3: use of multiple crosslinkers, mass spectrometry approaches and software platforms

(2018) Daniela-Lee Smith et al.   ANALYTICAL CHEMISTRY

A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates

(2018) Edmond Y. Huang et al.   MOLECULAR BIOLOGY OF THE CELL

Cholesterol increases protein levels of the E3 ligase MARCH6, and thereby stimulates protein degradation

(2018) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis

(2017) Ngee Kiat Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis

(2017) Anika V. Prabhu et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis

(2016) Anika V. Prabhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

(2016) Pei-Ling Tsai et al.   eLife

The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally

(2015) Winnie Luu et al.   JOURNAL OF LIPID RESEARCH

Disorders of Cholesterol Metabolism and Their Unanticipated Convergent Mechanisms of Disease

(2014) Frances M. Platt et al.   Annual Review of Genomics and Human Genetics

The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis

(2014) Anika V. Prabhu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme

(2014) Eser J. Zerenturk et al.   BIOSCIENCE REPORTS

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis

(2014) H. Meyer et al.   JOURNAL OF CELL SCIENCE

The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway

(2014) N. Zelcer et al.   MOLECULAR AND CELLULAR BIOLOGY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

The UPS and downs of cholesterol homeostasis

(2014) Laura J. Sharpe et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ubiquitin Ligases in Cholesterol Metabolism

(2014) Wei Jiang et al.   Diabetes & Metabolism Journal

Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis

(2013) Winnie Luu et al.   JOURNAL OF LIPID RESEARCH

RefSeq: an update on mammalian reference sequences

(2013) Kim D. Pruitt et al.   NUCLEIC ACIDS RESEARCH

Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: Cooperative induction of key enzymes in lipid synthesis by Sterol Regulatory Element Binding Proteins

(2012) Eser J. Zerenturk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)

(2011) Eser J. Zerenturk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Akt acutely activates the cholesterogenic transcription factor SREBP-2

(2011) Winnie Luu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

(2011) Saloni Gill et al.   Cell Metabolism

Solution Structure and Molecular Interactions of Lamin B Receptor Tudor Domain

(2011) Stamatis Liokatis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection and Characterization of Low Abundance Glycopeptides Via Higher-Energy C-Trap Dissociation and Orbitrap Mass Analysis

(2011) Gene Hart-Smith et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein

(2011) Peter Clayton et al.   Nucleus

Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box

(2010) Gianluca Schiavoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cholesterol Homeostasis in Two Commonly Used Human Prostate Cancer Cell-Lines, LNCaP and PC-3

(2009) James Robert Krycer et al.   PLoS One

Improved PCR method for the creation of saturation mutagenesis libraries in directed evolution: application to difficult-to-amplify templates

(2008) Joaquin Sanchis et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Disruption of the gene encoding 3β-hydroxysterol Δ14-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis

(2008) Anna M. Bennati et al.   FEBS Journal

The lamin B receptor under transcriptional control of C/EBPε is required for morphological but not functional maturation of neutrophils

(2008) Tatiana V. Cohen et al.   HUMAN MOLECULAR GENETICS

Side Chain Oxygenated Cholesterol Regulates Cellular Cholesterol Homeostasis through Direct Sterol-Membrane Interactions

(2008) Sarah E. Gale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY