Breaking the chains: deubiquitylating enzyme specificity begets function
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Title
Breaking the chains: deubiquitylating enzyme specificity begets function
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Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2019-02-07
DOI
10.1038/s41580-019-0099-1
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Note: Only part of the references are listed.- Pseudo-DUBs as allosteric activators and molecular scaffolds of protein complexes
- (2018) Miriam Walden et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Targeting HAUSP in both p53 wildtype and p53-mutant tumors
- (2018) Omid Tavana et al. CELL CYCLE
- Cezanne/OTUD7B is a cell cycle‐regulated deubiquitinase that antagonizes the degradation of APC/C substrates
- (2018) Thomas Bonacci et al. EMBO JOURNAL
- Dual role of USP30 in controlling basal pexophagy and mitophagy
- (2018) Elena Marcassa et al. EMBO REPORTS
- Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activities
- (2018) Xuan Xie et al. JOURNAL OF CELL SCIENCE
- Expansion of DUB functionality generated by alternative isoforms – USP35, a case study
- (2018) Pawel Leznicki et al. JOURNAL OF CELL SCIENCE
- Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
- (2018) Dominika Kwasna et al. MOLECULAR CELL
- ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability
- (2018) Peter Haahr et al. MOLECULAR CELL
- OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling
- (2018) Yu Zhao et al. MOLECULAR CELL
- L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage
- (2018) Somaira Nowsheen et al. NATURE CELL BIOLOGY
- Building and decoding ubiquitin chains for mitophagy
- (2018) J. Wade Harper et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains
- (2018) Fumiaki Ohtake et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A family of unconventional deubiquitinases with modular chain specificity determinants
- (2018) Thomas Hermanns et al. Nature Communications
- Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes
- (2018) David S. Hewings et al. Nature Communications
- USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A
- (2018) Michael Uckelmann et al. Nature Communications
- CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis
- (2018) Xènia Crespo-Yàñez et al. PLoS Genetics
- Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade
- (2018) Yiwei Wang et al. CELL RESEARCH
- Active site alanine mutations convert deubiquitinases into high‐affinity ubiquitin‐binding proteins
- (2018) Marie E Morrow et al. EMBO REPORTS
- OTULIN limits cell death and inflammation by deubiquitinating LUBAC
- (2018) Klaus Heger et al. NATURE
- LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis
- (2018) Nieves Peltzer et al. NATURE
- Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases
- (2017) Michael J. Clague et al. FEBS Journal
- The X-linked deubiquitinase USP9X is an integral component of centrosome
- (2017) Qian Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Meddling with Fate: The Proteasomal Deubiquitinating Enzymes
- (2017) Stefanie A.H. de Poot et al. JOURNAL OF MOLECULAR BIOLOGY
- Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics
- (2017) Brian L. Lee et al. JOURNAL OF MOLECULAR BIOLOGY
- RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage
- (2017) Atanu Paul et al. MOLECULAR CELL
- An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S Proteasome
- (2017) Evan J. Worden et al. MOLECULAR CELL
- USP7 small-molecule inhibitors interfere with ubiquitin binding
- (2017) Lorna Kategaya et al. NATURE
- Molecular basis of USP7 inhibition by selective small-molecule inhibitors
- (2017) Andrew P. Turnbull et al. NATURE
- Receptor oligomerization guides pathway choice between proteasomal and autophagic degradation
- (2017) Kefeng Lu et al. NATURE CELL BIOLOGY
- Discovery and characterization of highly potent and selective allosteric USP7 inhibitors
- (2017) Gerald Gavory et al. Nature Chemical Biology
- Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
- (2017) Robin M Meyers et al. NATURE GENETICS
- Deubiquitylating enzymes and drug discovery: emerging opportunities
- (2017) Jeanine A. Harrigan et al. NATURE REVIEWS DRUG DISCOVERY
- Mechanism and regulation of the Lys6-selective deubiquitinase USP30
- (2017) Malte Gersch et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30
- (2017) Yusuke Sato et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- PICKLES: the database of pooled in-vitro CRISPR knockout library essentiality screens
- (2017) Walter F Lenoir et al. NUCLEIC ACIDS RESEARCH
- Mechanism and regulation of the Lys6-selective deubiquitinase USP30
- (2017) Malte Gersch et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30
- (2017) Yusuke Sato et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens
- (2017) Traver Hart et al. G3-Genes Genomes Genetics
- Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation
- (2017) Sjoerd J. L. van Wijk et al. Nature Microbiology
- The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
- (2016) Rune Busk Damgaard et al. CELL
- Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C
- (2016) Nicholas G. Brown et al. CELL
- Ubiquitin modifications
- (2016) Kirby N Swatek et al. CELL RESEARCH
- SPATA2 links CYLD to the TNF‐α receptor signaling complex and modulates the receptor signaling outcomes
- (2016) Sebastian A Wagner et al. EMBO JOURNAL
- SPATA2 promotes CYLD activity and regulates TNF‐induced NF‐κB signaling and cell death
- (2016) Lisa Schlicher et al. EMBO REPORTS
- USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response
- (2016) Zhiquan Wang et al. GENES & DEVELOPMENT
- Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase
- (2016) Ryan T. VanderLinden et al. MOLECULAR CELL
- MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes
- (2016) Syed Arif Abdul Rehman et al. MOLECULAR CELL
- SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling
- (2016) Paul R. Elliott et al. MOLECULAR CELL
- The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling
- (2016) Fumiaki Ohtake et al. MOLECULAR CELL
- Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne
- (2016) Tycho E. T. Mevissen et al. NATURE
- USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites
- (2016) Byung-Hoon Lee et al. NATURE
- Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome
- (2016) Simone Cavadini et al. NATURE
- The increasing complexity of the ubiquitin code
- (2016) Richard Yau et al. NATURE CELL BIOLOGY
- HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma
- (2016) Omid Tavana et al. NATURE MEDICINE
- Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection
- (2016) Ruth M Densham et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
- (2016) Qing Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis for histone H2B deubiquitination by the SAGA DUB module
- (2016) M. T. Morgan et al. SCIENCE
- Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome
- (2016) Y. Shi et al. SCIENCE
- BAP1/ASXL1 recruitment and activation for H2A deubiquitination
- (2016) Danny D. Sahtoe et al. Nature Communications
- Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection
- (2016) Ruth M Densham et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity
- (2016) Nicolas Huguenin-Dezot et al. Cell Reports
- The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation
- (2016) Shaliny Ramachandran et al. Cell Reports
- SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes
- (2016) Sebastian Kupka et al. Cell Reports
- CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
- (2016) Matous Hrdinka et al. Cell Reports
- Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition
- (2016) Corey M Dambacher et al. eLife
- Global, quantitative and dynamic mapping of protein subcellular localization
- (2016) Daniel N Itzhak et al. eLife
- Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin–proteasome system
- (2015) Chris McKinnon et al. ACTA NEUROPATHOLOGICA
- Deubiquitinating enzymes regulate PARK2-mediated mitophagy
- (2015) Yuqing Wang et al. Autophagy
- Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer
- (2015) Grace O. Silva et al. BREAST CANCER RESEARCH AND TREATMENT
- Recurrent gain-of-function USP8 mutations in Cushing's disease
- (2015) Zeng-Yi Ma et al. CELL RESEARCH
- USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death
- (2015) J.-R. Liang et al. EMBO REPORTS
- The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer
- (2015) Salima Daou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of Deubiquitinating Enzymes in DNA Repair
- (2015) Younghoon Kee et al. MOLECULAR AND CELLULAR BIOLOGY
- Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G
- (2015) Danny D. Sahtoe et al. MOLECULAR CELL
- Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response
- (2015) Andrew E.H. Elia et al. MOLECULAR CELL
- Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage
- (2015) Tina Thorslund et al. NATURE
- Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
- (2015) Ingrid E. Wertz et al. NATURE
- A mechanism for the suppression of homologous recombination in G1 cells
- (2015) Alexandre Orthwein et al. NATURE
- USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
- (2015) Christian N. Cunningham et al. NATURE CELL BIOLOGY
- Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest)
- (2015) Manuela K Hospenthal et al. Nature Protocols
- Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity
- (2015) Yusuke Sato et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Substrate degradation by the proteasome: A single-molecule kinetic analysis
- (2015) Y. Lu et al. SCIENCE
- The demographics of the ubiquitin system
- (2015) Michael J. Clague et al. TRENDS IN CELL BIOLOGY
- Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity
- (2015) Yusuke Sato et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Ubiquitin-specific protease 14 modulates degradation of cellular prion protein
- (2015) Takujiro Homma et al. Scientific Reports
- LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes
- (2015) Peter Draber et al. Cell Reports
- Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
- (2014) Agne Kazlauskaite et al. BIOCHEMICAL JOURNAL
- Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product
- (2014) Rashmi K. Shrestha et al. BIOCHEMISTRY
- Writing and reading H2B monoubiquitylation
- (2014) Gilad Fuchs et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Enhanced Protein Degradation by Branched Ubiquitin Chains
- (2014) Hermann-Josef Meyer et al. CELL
- Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
- (2014) T. Wauer et al. EMBO JOURNAL
- USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin
- (2014) T. M. Durcan et al. EMBO JOURNAL
- Ubiquitin acetylation inhibits polyubiquitin chain elongation
- (2014) F. Ohtake et al. EMBO REPORTS
- The deubiquitinase activity of A20 is dispensable for NF- B signaling
- (2014) A. De et al. EMBO REPORTS
- Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN
- (2014) Tsuyoshi Takiuchi et al. GENES TO CELLS
- PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
- (2014) Lesley A. Kane et al. JOURNAL OF CELL BIOLOGY
- A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II
- (2014) S. Hutten et al. JOURNAL OF CELL SCIENCE
- Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis
- (2014) Alban Ordureau et al. MOLECULAR CELL
- Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling
- (2014) Veronique Schaeffer et al. MOLECULAR CELL
- Molecular Basis and Regulation of OTULIN-LUBAC Interaction
- (2014) Paul R. Elliott et al. MOLECULAR CELL
- The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
- (2014) Baris Bingol et al. NATURE
- Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity
- (2014) Ryotaro Nishi et al. NATURE CELL BIOLOGY
- Mutations in the deubiquitinase gene USP8 cause Cushing's disease
- (2014) Martin Reincke et al. NATURE GENETICS
- Structure of the Rpn11–Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation
- (2014) Evan J Worden et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
- (2014) G. R. Pathare et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Screening of DUB activity and specificity by MALDI-TOF mass spectrometry
- (2014) Maria Stella Ritorto et al. Nature Communications
- HOIP Deficiency Causes Embryonic Lethality by Aberrant TNFR1-Mediated Endothelial Cell Death
- (2014) Nieves Peltzer et al. Cell Reports
- Dual Regulation of Fbw7 Function and Oncogenic Transformation by Usp28
- (2014) Christina Schülein-Völk et al. Cell Reports
- Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity
- (2014) A. Kazlauskaite et al. Open Biology
- OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis
- (2013) Tycho E.T. Mevissen et al. CELL
- OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin
- (2013) Kirstin Keusekotten et al. CELL
- Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity
- (2013) Jorg van Loosdregt et al. IMMUNITY
- Dimerization and Ubiquitin Mediated Recruitment of A20, a Complex Deubiquitinating Enzyme
- (2013) Timothy T. Lu et al. IMMUNITY
- OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling
- (2013) Berthe Katrine Fiil et al. MOLECULAR CELL
- The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis
- (2013) Elena Rivkin et al. NATURE
- 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
- (2013) Amélie Fradet-Turcotte et al. NATURE
- USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110
- (2013) Ji Li et al. NATURE
- Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly–capillary malformation syndrome
- (2013) Laura M McDonell et al. NATURE GENETICS
- Conformational switching of the 26S proteasome enables substrate degradation
- (2013) Mary E Matyskiela et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks
- (2013) S. M. H. Sy et al. NUCLEIC ACIDS RESEARCH
- Deubiquitylases From Genes to Organism
- (2013) Michael J. Clague et al. PHYSIOLOGICAL REVIEWS
- Lysine 63-linked polyubiquitination is required for EGF receptor degradation
- (2013) F. Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains
- (2013) C. H. Emmerich et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A20 in inflammation and autoimmunity
- (2013) Leen Catrysse et al. TRENDS IN IMMUNOLOGY
- A BRISC-SHMT Complex Deubiquitinates IFNAR1 and Regulates Interferon Responses
- (2013) Hui Zheng et al. Cell Reports
- The Ubiquitin Code
- (2012) David Komander et al. Annual Review of Biochemistry
- A common ancestry for BAP1 and Uch37 regulators
- (2012) Luis Sanchez-Pulido et al. BIOINFORMATICS
- Generation and physiological roles of linear ubiquitin chains
- (2012) Henning Walczak et al. BMC BIOLOGY
- A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance
- (2012) Dharminder Chauhan et al. CANCER CELL
- RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling
- (2012) Francesca Mattiroli et al. CELL
- Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation
- (2012) Michael J. Clague et al. DEVELOPMENTAL CELL
- Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions
- (2012) Sarah Schulz et al. EMBO REPORTS
- Selectivity of the ubiquitin-binding modules
- (2012) Simin Rahighi et al. FEBS LETTERS
- A20 and CYLD Do Not Share Significant Overlapping Functions during B Cell Development and Activation
- (2012) Yuanyuan Chu et al. JOURNAL OF IMMUNOLOGY
- Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions
- (2012) Sylvie Urbé et al. MOLECULAR BIOLOGY OF THE CELL
- OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function
- (2012) Yu-Chi Juang et al. MOLECULAR CELL
- The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity
- (2012) Rune Busk Damgaard et al. MOLECULAR CELL
- The mechanism of OTUB1-mediated inhibition of ubiquitination
- (2012) Reuven Wiener et al. NATURE
- Near-atomic resolution structural model of the yeast 26S proteasome
- (2012) F. Beck et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Conserved Deubiquitinating Enzyme Controls Cell Growth by Regulating RNA Polymerase I Stability
- (2012) Lauren A. Richardson et al. Cell Reports
- Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chains
- (2011) Zi-Ren Zhou et al. BIOCHEMICAL JOURNAL
- The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2
- (2011) Katherine E. Wickliffe et al. CELL
- USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A
- (2011) Xiao-yong Zhang et al. CELL CYCLE
- The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types
- (2011) Alex C. Faesen et al. CHEMISTRY & BIOLOGY
- Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers
- (2011) M. H. Abdel-Rahman et al. JOURNAL OF MEDICAL GENETICS
- Regulation of Ubiquitin Chain Initiation to Control the Timing of Substrate Degradation
- (2011) Adam Williamson et al. MOLECULAR CELL
- Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination
- (2011) Kyosuke Nakamura et al. MOLECULAR CELL
- Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks
- (2011) Lilach Moyal et al. MOLECULAR CELL
- Mechanism of USP7/HAUSP Activation by Its C-Terminal Ubiquitin-like Domain and Allosteric Regulation by GMP-Synthetase
- (2011) Alex C. Faesen et al. MOLECULAR CELL
- SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
- (2011) Fumiyo Ikeda et al. NATURE
- Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin pools
- (2011) Stephen E Kaiser et al. NATURE METHODS
- Isoform-Specific Localization of the Deubiquitinase USP33 to the Golgi Apparatus
- (2011) Christopher Thorne et al. TRAFFIC
- Ubiquitin: Same Molecule, Different Degradation Pathways
- (2010) Michael J. Clague et al. CELL
- K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody
- (2010) Marissa L. Matsumoto et al. MOLECULAR CELL
- Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
- (2010) Shinichiro Nakada et al. NATURE
- Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
- (2010) Johanna C. Scheuermann et al. NATURE
- Enhancement of proteasome activity by a small-molecule inhibitor of USP14
- (2010) Byung-Hoon Lee et al. NATURE
- Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase
- (2010) Satpal Virdee et al. Nature Chemical Biology
- Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne
- (2010) Anja Bremm et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation
- (2009) Simin Rahighi et al. CELL
- The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates
- (2009) Gerco C Hassink et al. EMBO REPORTS
- Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains
- (2009) David Komander et al. EMBO REPORTS
- Specificity of the BRISC Deubiquitinating Enzyme Is Not Due to Selective Binding to Lys63-linked Polyubiquitin
- (2009) Eric M. Cooper et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin
- (2009) Helene Faustrup et al. JOURNAL OF CELL BIOLOGY
- Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction
- (2009) Tobias L. Haas et al. MOLECULAR CELL
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- (2009) Martin Schwickart et al. NATURE
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- (2009) Mathew J. Garnett et al. NATURE CELL BIOLOGY
- Breaking the chains: structure and function of the deubiquitinases
- (2009) David Komander et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2008) Brett J. Winborn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- USP19 Deubiquitinating Enzyme Supports Cell Proliferation by Stabilizing KPC1, a Ubiquitin Ligase for p27Kip1
- (2008) Y. Lu et al. MOLECULAR AND CELLULAR BIOLOGY
- Regulation of Mitochondrial Morphology by USP30, a Deubiquitinating Enzyme Present in the Mitochondrial Outer Membrane
- (2008) Nobuhiro Nakamura et al. MOLECULAR BIOLOGY OF THE CELL
- Distinct Modes of Regulation of the Uch37 Deubiquitinating Enzyme in the Proteasome and in the Ino80 Chromatin-Remodeling Complex
- (2008) Tingting Yao et al. MOLECULAR CELL
- The Structure of the CYLD USP Domain Explains Its Specificity for Lys63-Linked Polyubiquitin and Reveals a B Box Module
- (2008) David Komander et al. MOLECULAR CELL
- Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains
- (2008) Yusuke Sato et al. NATURE
- The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network
- (2008) Min Sup Song et al. NATURE
- Zinc-finger UBPs: regulators of deubiquitylation
- (2008) Jacques Bonnet et al. TRENDS IN BIOCHEMICAL SCIENCES
- Structure of the A20 OTU domain and mechanistic insights into deubiquitination
- (2007) David Komander et al. BIOCHEMICAL JOURNAL
- Relative Structural and Functional Roles of Multiple Deubiquitylating Proteins Associated with Mammalian 26S Proteasome
- (2007) Elena Koulich et al. MOLECULAR BIOLOGY OF THE CELL
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