Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP+

Can case study approaches speed implementation of the NRC report: “Toxicity Testing in the 21st Century: A Vision and a Strategy?”

(2014) Melvin Andersen   ALTEX-Alternatives to Animal Experimentation

Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases

(2014) Stefan Schildknecht   ALTEX-Alternatives to Animal Experimentation

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Improving the Human Hazard Characterization of Chemicals: A Tox21 Update

(2013) Raymond R. Tice et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

ATF4 Protects Against Neuronal Death in Cellular Parkinson's Disease Models by Maintaining Levels of Parkin

(2013) X. Sun et al.   JOURNAL OF NEUROSCIENCE

Integrating Pathways of Parkinson's Disease in a Molecular Interaction Map

(2013) Kazuhiro A. Fujita et al.   MOLECULAR NEUROBIOLOGY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Metabolic States Following Accumulation of Intracellular Aggregates: Implications for Neurodegenerative Diseases

(2013) Alexei Vazquez   PLoS One

Systems Biology Approach Identifies the Kinase Csnk1a1 as a Regulator of the DNA Damage Response in Embryonic Stem Cells

(2013) J. Carreras Puigvert et al.   Science Signaling

Temporal Concordance Between Apical and Transcriptional Points of Departure for Chemical Risk Assessment

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

MPP+-induces PUMA- and p53-dependent, but ATF3-independent cell death

(2013) Alison I. Bernstein et al.   TOXICOLOGY LETTERS

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

(2012) Anne K. Krug et al.   ARCHIVES OF TOXICOLOGY

Systems biology tools for toxicology

(2012) Suzanne Geenen et al.   ARCHIVES OF TOXICOLOGY

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

Paraspeckle nuclear bodies—useful uselessness?

(2012) Shinichi Nakagawa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome

(2012) Nina V. Balmer et al.   HUMAN MOLECULAR GENETICS

Integrated Stress Response Modulates Cellular Redox State via Induction of Cystathionine γ-Lyase

(2012) Jeffrey G. Dickhout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition

(2012) Amila Suraweera et al.   MOLECULAR CELL

Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma

(2012) Lawrence N Kwong et al.   NATURE MEDICINE

Control of Aβ release from human neurons by differentiation status and RET signaling

(2012) Diana Scholz et al.   NEUROBIOLOGY OF AGING

Whole genome expression profile in neuroblastoma cells exposed to 1-methyl-4-phenylpyridine

(2012) E. Mazzio et al.   NEUROTOXICOLOGY

Identification of Thalidomide-Specific Transcriptomics and Proteomics Signatures during Differentiation of Human Embryonic Stem Cells

(2012) Kesavan Meganathan et al.   PLoS One

Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation

(2012) D. M. Passon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell Activation Is Driven by an ADP-Dependent Glucokinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation

(2012) Marcin M. Kamiński et al.   Cell Reports

Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence

(2012) Alexey Kolodkin et al.   Frontiers in Physiology

Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression

(2011) J Lewerenz et al.   CELL DEATH AND DIFFERENTIATION

Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line

(2011) Diana Scholz et al.   JOURNAL OF NEUROCHEMISTRY

Alterations in the Mitochondrial Proteome of Neuroblastoma Cells in Response to Complex 1 Inhibition

(2011) Florence Burté et al.   JOURNAL OF PROTEOME RESEARCH

A tale on animal models of Parkinson's disease

(2011) Erwan Bezard et al.   MOVEMENT DISORDERS

Uncoupling of ATP-depletion and cell death in human dopaminergic neurons

(2011) Dominik Pöltl et al.   NEUROTOXICOLOGY

Transcriptomic Concentration-Response Evaluation of Valproic Acid, Cyproconazole, and Hexaconazole in the Neural Embryonic Stem Cell Test (ESTn)

(2011) Peter T. Theunissen et al.   TOXICOLOGICAL SCIENCES

Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+-induced neurodegeneration

(2010) Daniele Cartelli et al.   JOURNAL OF NEUROCHEMISTRY

Region-Specific Protein Abundance Changes in the Brain of MPTP-Induced Parkinson’s Disease Mouse Model

(2010) Xu Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

(2010) Leo Neumann et al.   Molecular Systems Biology

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways

(2010) Jeremy A. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network

(2010) Lufang Zhou et al.   PLoS Computational Biology

MetaboliteDetector: Comprehensive Analysis Tool for Targeted and Nontargeted GC/MS Based Metabolome Analysis

(2009) Karsten Hiller et al.   ANALYTICAL CHEMISTRY

hnRNP M interacts with PSF and p54nrb and co-localizes within defined nuclear structures

(2009) Marija Marko et al.   EXPERIMENTAL CELL RESEARCH

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells

(2009) Stefan Schildknecht et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

(2008) Philipp S. Lange et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine resistance revealed by transcriptome mapping in mouse striatum

(2008) R. Pattarini et al.   NEUROSCIENCE

Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat

(2008) W.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE