Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

(2019) Jie Li et al.   eLife

GDF15 mediates the effects of metformin on body weight and energy balance

(2019) Anthony P. Coll et al.   NATURE

Cancer-associated cachexia

(2018) Vickie E. Baracos et al.   Nature Reviews Disease Primers

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases

(2018) Vicky W.W. Tsai et al.   Cell Metabolism

Encoding of danger by parabrachial CGRP neurons

(2018) Carlos A. Campos et al.   NATURE

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

Growth differentiation factor 15 is a promising diagnostic and prognostic biomarker in colorectal cancer

(2016) Chen Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia

(2016) Tomoya Fukawa et al.   NATURE MEDICINE

The central role of hypothalamic inflammation in the acute illness response and cachexia

(2016) Kevin G. Burfeind et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

MAP3K11/GDF15 axis is a critical driver of cancer cachexia

(2015) Lorena Lerner et al.   Journal of Cachexia Sarcopenia and Muscle

Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients

(2015) Lorena Lerner et al.   Journal of Cachexia Sarcopenia and Muscle

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

(2011) S. K. Das et al.   SCIENCE

Measuring protein breakdown rate in individual proteins in vivo

(2010) Lars Holm et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Growth differentiation factor-15 as a prognostic biomarker in ovarian cancer

(2010) Anne Cathrine Staff et al.   GYNECOLOGIC ONCOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Progressive Postnatal Motoneuron Loss in Mice Lacking GDF-15

(2009) J. Strelau et al.   JOURNAL OF NEUROSCIENCE

Lipolysis-Not inflammation, cell death, or lipogenesis-Is involved in adipose tissue loss in cancer cachexia

(2008) Mikael Rydén et al.   CANCER

Cachexia: A new definition

(2008) William J. Evans et al.   CLINICAL NUTRITION

The Structure of the Glial Cell Line-derived Neurotrophic Factor-Coreceptor Complex

(2008) Vimal Parkash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY