GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF- RII heterodimer

(2016) A. Artz et al.   BLOOD

GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells

(2016) Hyejin Park et al.   Oncotarget

Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels

(2016) Dong-Dong Liu et al.   Scientific Reports

Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI

(2015) Vicky Wang-Wei Tsai et al.   PLoS One

Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity

(2014) Simon Musyoka Mwangi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Anorectic Actions of the TGFβ Cytokine MIC-1/GDF15 Require an Intact Brainstem Area Postrema and Nucleus of the Solitary Tract

(2014) Vicky Wang-Wei Tsai et al.   PLoS One

TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

(2013) Vicky Wang-Wei Tsai et al.   PLoS One

Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets

(2012) Laurence Macia et al.   PLoS One

Progressive Postnatal Motoneuron Loss in Mice Lacking GDF-15

(2009) J. Strelau et al.   JOURNAL OF NEUROSCIENCE