Emerging potential of cannabidiol in reversing proteinopathies

Chronic Treatment with 50 mg/kg Cannabidiol Improves Cognition and Moderately Reduces Aβ42 Levels in 12-Month-Old Male AβPPswe/PS1ΔE9 Transgenic Mice

(2020) Georgia Watt et al.   JOURNAL OF ALZHEIMERS DISEASE

The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy

(2020) Maximilian G. Christ et al.   TRENDS IN NEUROSCIENCES

Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer’s Disease

(2020) Emilio Llanos-González et al.   Frontiers in Neuroscience

Therapeutic Advances for Huntington’s Disease

(2020) Ashok Kumar et al.   Brain Sciences

Cannabidiol exerts protective effects in an in vitro model of Parkinson's disease activating AKT/mTOR pathway

(2020) Agnese Gugliandolo et al.   FITOTERAPIA

Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells

(2019) Soyeon Jeong et al.   CANCER LETTERS

Brain aging: A Ianus -faced player between health and neurodegeneration

(2019) Silvia Vanni et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cannabinoid Ligands Targeting TRP Channels

(2019) Chanté Muller et al.   Frontiers in Molecular Neuroscience

Protein misfolding and aggregation in neurodegenerative diseases: a review of pathogeneses, novel detection strategies, and potential therapeutics

(2019) Jason Gandhi et al.   REVIEWS IN THE NEUROSCIENCES

Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer’s Disease

(2019) David Schubert et al.   MOLECULAR NEUROBIOLOGY

Cannabidiol Enhances the Therapeutic Effects of TRAIL by Upregulating DR5 in Colorectal Cancer

(2019) Jung Lim Kim et al.   Cancers

Combination of cannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), mitigates experimental autoimmune encephalomyelitis (EAE) by altering the gut microbiome

(2019) Zinah Z. Al-Ghezi et al.   BRAIN BEHAVIOR AND IMMUNITY

Cannabidiol Adverse Effects and Toxicity

(2019) Marilyn A. Huestis et al.   Current Neuropharmacology

Therapeutic impact of orally administered cannabinoid oil extracts in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis

(2019) Ting Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Real world experience of patients with amyotrophic lateral sclerosis (ALS) in the treatment of spasticity using tetrahydrocannabinol:cannabidiol (THC:CBD)

(2019) Thomas Meyer et al.   BMC Neurology

Cannabidiol attenuates aggressive behavior induced by social isolation in mice: Involvement of 5-HT1A and CB1 receptors

(2019) Alice Hartmann et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Combination of Cannabinoids, Δ9- Tetrahydrocannabinol and Cannabidiol, Ameliorates Experimental Multiple Sclerosis by Suppressing Neuroinflammation Through Regulation of miRNA-Mediated Signaling Pathways

(2019) Zinah Zamil Al-Ghezi et al.   Frontiers in Immunology

Cannabidiol prevents LPS‐induced microglial inflammation by inhibiting ROS/NF‐κB‐dependent signaling and glucose consumption

(2019) Mauricio dos‐Santos‐Pereira et al.   GLIA

Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer

(2019) Soyeon Jeong et al.   Cell Death & Disease

Study protocol for a randomised, double-blind, placebo-controlled study evaluating the Efficacy of cannabis-based Medicine Extract in slowing the disease pRogression of Amyotrophic Lateral sclerosis or motor neurone Disease: the EMERALD trial

(2019) Berzenn Urbi et al.   BMJ Open

HSP70 and HSP90 in neurodegenerative diseases

(2019) Abha Gupta et al.   NEUROSCIENCE LETTERS

Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1

(2019) Laura Casares et al.   Redox Biology

Antioxidative and Anti-Inflammatory Properties of Cannabidiol

(2019) Sinemyiz Atalay et al.   Antioxidants

Neuroprotection in Oxidative Stress-Related Neurodegenerative Diseases: Role of Endocannabinoid System Modulation

(2018) Janos Paloczi et al.   ANTIOXIDANTS & REDOX SIGNALING

The Use of Cannabis and Cannabinoids in Treating Symptoms of Multiple Sclerosis: a Systematic Review of Reviews

(2018) Suzanne Nielsen et al.   Current Neurology and Neuroscience Reports

Maintaining a Healthy Proteome during Oxidative Stress

(2018) Dana Reichmann et al.   MOLECULAR CELL

Effect of Chronic Oxidative Stress on Neuroinflammatory Response Mediated by CD4+T Cells in Neurodegenerative Diseases

(2018) Helena Solleiro-Villavicencio et al.   Frontiers in Cellular Neuroscience

Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis

(2018) Santa Mammana et al.   Oncotarget

Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?

(2018) Fernanda F. Peres et al.   Frontiers in Pharmacology

Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy

(2018) Maria J. Casarejos et al.   JOURNAL OF ALZHEIMERS DISEASE

Cannabis-Based Medicine Reduces Multiple Pathological Processes in AβPP/PS1 Mice

(2018) Ester Aso et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Cannabidiol Treatment Prevents the Development of Social Recognition Memory Deficits in Alzheimer's Disease Transgenic Mice

(2018) David Cheng et al.   JOURNAL OF ALZHEIMERS DISEASE

Inhibitory effects of cannabidiol on voltage-dependent sodium currents

(2018) Mohammad-Reza Ghovanloo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history

(2018) Sara Anna Bonini et al.   JOURNAL OF ETHNOPHARMACOLOGY

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

(2018) Barry Boland et al.   NATURE REVIEWS DRUG DISCOVERY

Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor

(2018) María Rodríguez-Muñoz et al.   Molecular Brain

Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells

(2018) David M. Elliott et al.   Frontiers in Immunology

Targeting the proteostasis network in Huntington’s disease

(2018) Tânia R. Soares et al.   AGEING RESEARCH REVIEWS

Alzheimer's disease therapeutic candidate SAK3 is an enhancer of T-type calcium channels

(2018) Kohji Fukunaga et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1

(2018) Bruno Alexandre Quadros Gomes et al.   Oxidative Medicine and Cellular Longevity

Avidekel Cannabis extracts and cannabidiol are as efficient as Copaxone in suppressing EAE in SJL/J mice

(2018) Ruth Gallily et al.   INFLAMMOPHARMACOLOGY

Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients

(2018) Ewa Ambrożewicz et al.   Cells

Safety and efficacy of nabiximols on spasticity symptoms in patients with motor neuron disease (CANALS): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

(2018) Nilo Riva et al.   LANCET NEUROLOGY

Huntington's disease: a clinical review

(2017) P. McColgan et al.   EUROPEAN JOURNAL OF NEUROLOGY

Target regulation of PI3K/Akt/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis

(2017) Sabrina Giacoppo et al.   FITOTERAPIA

Effects of a Sativex-Like Combination of Phytocannabinoids on Disease Progression in R6/2 Mice, an Experimental Model of Huntington’s Disease

(2017) Sara Valdeolivas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions

(2017) Amulya Nidhi Shrivastava et al.   NEURON

Cannabinoids as hippocampal network administrators

(2017) Carl R. Lupica et al.   NEUROPHARMACOLOGY

Autophagic flux control in neurodegeneration: Progress and precision targeting—Where do we stand?

(2017) Dumisile Lumkwana et al.   PROGRESS IN NEUROBIOLOGY

Nutrient Sensing and the Oxidative Stress Response

(2017) Hanzhi Luo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Proteostasis, oxidative stress and aging

(2017) Ioanna Korovila et al.   Redox Biology

Danger: High Voltage—The Role of Voltage-Gated Calcium Channels in Central Nervous System Pathology

(2017) Andrea Schampel et al.   Cells

Accumulated Amyloid-β Peptide and Hyperphosphorylated Tau Protein: Relationship and Links in Alzheimer's Disease

(2017) Han-Chang Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

Cannabidiol attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury

(2017) Yuping Wang et al.   Scientific Reports

Tetrahydrocannabinol:Cannabidiol Oromucosal Spray for Multiple Sclerosis-Related Resistant Spasticity in Daily Practice

(2016) Patrick Vermersch et al.   EUROPEAN NEUROLOGY

Anticancer activity of glucomoringin isothiocyanate in human malignant astrocytoma cells

(2016) Thangavelu Soundara Rajan et al.   FITOTERAPIA

Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model

(2016) Ester Aso et al.   JOURNAL OF ALZHEIMERS DISEASE

Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis

(2016) Thangavelu Soundara Rajan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure

(2016) Mahshid Hosseinzadeh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The clinical symptoms of Parkinson's disease

(2016) Sigurlaug Sveinbjornsdottir   JOURNAL OF NEUROCHEMISTRY

A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington’s disease

(2016) Jose Luis López-Sendón Moreno et al.   JOURNAL OF NEUROLOGY

Cannabidiol Limits T Cell-Mediated Chronic Autoimmune Myocarditis: Implications to Autoimmune Disorders and Organ Transplantation

(2016) Wen-Shin Lee et al.   MOLECULAR MEDICINE

Phytocannabinoids: a unified critical inventory

(2016) Lumír Ondřej Hanuš et al.   NATURAL PRODUCT REPORTS

Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?

(2016) Emanuela Mazzon et al.   Neural Regeneration Research

Dysfunction of NMDA receptors in Alzheimer’s disease

(2016) Yan Zhang et al.   NEUROLOGICAL SCIENCES

Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors

(2016) Raquel Linge et al.   NEUROPHARMACOLOGY

Cannabidiol, neuroprotection and neuropsychiatric disorders

(2016) Alline C. Campos et al.   PHARMACOLOGICAL RESEARCH

Modulation of cellular redox homeostasis by the endocannabinoid system

(2016) Christopher Lipina et al.   Open Biology

Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies

(2016) Francisco J. Carvajal et al.   NEURAL PLASTICITY

Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats

(2016) Fernanda F. Peres et al.   Frontiers in Pharmacology

Common molecular mechanism of amyloid pore formation by Alzheimer’s β-amyloid peptide and α-synuclein

(2016) Coralie Di Scala et al.   Scientific Reports

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

The σ1 Receptor Engages the Redox-Regulated HINT1 Protein to Bring Opioid Analgesia Under NMDA Receptor Negative Control

(2015) María Rodríguez-Muñoz et al.   ANTIOXIDANTS & REDOX SIGNALING

Interactions between misfolded protein oligomers and membranes: A central topic in neurodegenerative diseases?

(2015) Maria Andreasen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A Sativex®-like combination of phytocannabinoids as a disease-modifying therapy in a viral model of multiple sclerosis

(2015) A Feliú et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of cannabidiol on contractions and calcium signaling in rat ventricular myocytes

(2015) Ramez M. Ali et al.   CELL CALCIUM

An overview on neuroprotective effects of isothiocyanates for the treatment of neurodegenerative diseases

(2015) Sabrina Giacoppo et al.   FITOTERAPIA

Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner

(2015) Massimo Nabissi et al.   INTERNATIONAL JOURNAL OF CANCER

Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells

(2015) Ewa Kozela et al.   Journal of Neuroinflammation

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria

(2015) A.C. Campos et al.   NEUROSCIENCE

Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release

(2015) Pedro H. Gobira et al.   NEUROTOXICOLOGY

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity

(2015) Buvana Ravishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neuroprotection of cannabidiol against MPP + -induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson's disease

(2015) Neife Aparecida Guinaim Santos et al.   TOXICOLOGY IN VITRO

The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: Implications in neurological disorders

(2015) María Rodríguez-Muñoz et al.   Oncotarget

Plant polyphenols as inhibitors of NF-κB induced cytokine production—a potential anti-inflammatory treatment for Alzheimer's disease?

(2015) Niloo Karunaweera et al.   Frontiers in Molecular Neuroscience

The disease-modifying effects of a Sativex-like combination of phytocannabinoids in mice with experimental autoimmune encephalomyelitis are preferentially due to Δ9-tetrahydrocannabinol acting through CB1 receptors

(2015) Miguel Moreno-Martet et al.   Multiple Sclerosis and Related Disorders

A new formulation of cannabidiol in cream shows therapeutic effects in a mouse model of experimental autoimmune encephalomyelitis

(2015) Sabrina Giacoppo et al.   DARU-Journal of Pharmaceutical Sciences

Mitochondrial Dysfunction in Parkinson's Disease

(2015) Hyo Eun Moon et al.   Experimental Neurobiology

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Cannabinoid-induced autophagy regulates suppressor of cytokine signaling-3 in intestinal epithelium

(2014) Luan C. Koay et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Age-dependent metabolic dysregulation in cancer and Alzheimer’s disease

(2014) Richard A. Harris et al.   BIOGERONTOLOGY

Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

(2014) Orrin Devinsky et al.   EPILEPSIA

Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy

(2014) Lili Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases

(2014) Pilar Sánchez-Blázquez et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes

(2014) Attila Oláh et al.   JOURNAL OF CLINICAL INVESTIGATION

Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series

(2014) M. H. N. Chagas et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial

(2014) Marcos Hortes N Chagas et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Proteostasis and the Aging Proteome in Health and Disease

(2014) R. I. Morimoto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Combination of Cannabidiol and  9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model

(2014) K. A. Scott et al.   MOLECULAR CANCER THERAPEUTICS

Protective Effects of Cannabidiol Against Hippocampal Cell Death and Cognitive Impairment Induced by Bilateral Common Carotid Artery Occlusion in Mice

(2014) Angélica Pupin Schiavon et al.   NEUROTOXICITY RESEARCH

Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice

(2014) David Cheng et al.   PSYCHOPHARMACOLOGY

Proteostasis impairment in protein-misfolding and -aggregation diseases

(2014) Mark S. Hipp et al.   TRENDS IN CELL BIOLOGY

Cannabidiol: Promise and Pitfalls

(2014) Timothy E. Welty et al.   Epilepsy Currents

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

(2013) Sovan Sarkar   BIOCHEMICAL SOCIETY TRANSACTIONS

Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy

(2013) Keiji Tanaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Neuroprotection and reduction of glial reaction by cannabidiol treatment after sciatic nerve transection in neonatal rats

(2013) Matheus Perez et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Effects of cannabidiol on the function of α7-nicotinic acetylcholine receptors

(2013) Mohamed Mahgoub et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Thinking laterally about neurodegenerative proteinopathies

(2013) Todd E. Golde et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors

(2013) M. Mecha et al.   NEUROBIOLOGY OF DISEASE

Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+Cells Through PPARγ Involvement

(2013) Caterina Scuderi et al.   PHYTOTHERAPY RESEARCH

Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington’s Disease: Role of CB1 and CB2 Receptors

(2012) Sara Valdeolivas et al.   ACS Chemical Neuroscience

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

(2012) Javier Fernández-Ruiz et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization

(2012) L Romero et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis

(2012) Tatiana Barichello et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxidative stress and inflammation biomarkers in the blood of patients with Huntington’s disease

(2012) Fernando Sánchez-López et al.   NEUROLOGICAL RESEARCH

Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro

(2012) Benjamin S. Harvey et al.   NEUROTOXICOLOGY

Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities

(2012) R. G. Pertwee   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

(2012) A. C. Campos et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures

(2012) Rudolf Moldzio et al.   PHYTOMEDICINE

Ion channels induced by the prion protein

(2012) Isaac H. Solomon et al.   Prion

Cannabidiol protects oligodendrocyte progenitor cells from inflammation-induced apoptosis by attenuating endoplasmic reticulum stress

(2012) M Mecha et al.   Cell Death & Disease

Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Regulates Thrombospondin-1 and Nox4 Expression in Hypoxia-Induced Human Pulmonary Artery Smooth Muscle Cell Proliferation

(2012) David E. Green et al.   Pulmonary Circulation

Heat Shock Protein 70 Prevents both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport

(2011) Kristina R. Patterson et al.   BIOCHEMISTRY

Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice

(2011) Ewa Kozela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9-tetrahydrocannabinol in BV-2 microglial cells

(2011) Ana Juknat et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae

(2011) K. A. Morano et al.   GENETICS

Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study

(2011) Lourdes Ruiz-Valdepeñas et al.   Journal of Neuroinflammation

Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease

(2011) Onintza Sagredo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy

(2011) A. Shrivastava et al.   MOLECULAR CANCER THERAPEUTICS

Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease

(2011) A. M. Martin-Moreno et al.   MOLECULAR PHARMACOLOGY

The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease

(2011) Klaus Seppi et al.   MOVEMENT DISORDERS

Clinical diagnosis and management of amyotrophic lateral sclerosis

(2011) Orla Hardiman et al.   Nature Reviews Neurology

Oxidative Stress in Neurodegenerative Diseases: Mechanisms and Therapeutic Perspectives

(2011) Ailton Melo et al.   Oxidative Medicine and Cellular Longevity

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

(2011) Giuseppe Esposito et al.   PLoS One

Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis

(2011) M P Lim et al.   Cell Death & Disease

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Effects of cannabinoids and cannabinoid-enrichedCannabisextracts on TRP channels and endocannabinoid metabolic enzymes

(2010) Luciano De Petrocellis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study

(2010) Celia J. A. Morgan et al.   BRITISH JOURNAL OF PSYCHIATRY

Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress

(2010) Ulrike Seifert et al.   CELL

The Role of Tau in Alzheimer's Disease and Related Disorders

(2010) Rodrigo Medeiros et al.   CNS Neuroscience & Therapeutics

Intrinsic disorder in proteins associated with neurodegenerative diseases

(2010) Vladimir et al.   Frontiers in Bioscience-Landmark

Redox Reactions Induced by Nitrosative Stress Mediate Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases

(2010) Zezong Gu et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial therapies for Parkinson's disease

(2010) Bobby Thomas et al.   MOVEMENT DISORDERS

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Integration of Clearance Mechanisms: The Proteasome and Autophagy

(2010) E. Wong et al.   Cold Spring Harbor Perspectives in Biology

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages

(2009) Rosa María Tolón et al.   BRAIN RESEARCH

Cannabidiol: A Promising Drug for Neurodegenerative Disorders?

(2009) Teresa Iuvone et al.   CNS Neuroscience & Therapeutics

Time-dependent vascular actions of cannabidiol in the rat aorta

(2009) Saoirse E. O'Sullivan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cannabinoid CB2receptor agonists protect the striatum against malonate toxicity: Relevance for Huntington's disease

(2009) Onintza Sagredo et al.   GLIA

Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells

(2009) Ewa Kozela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo

(2009) N. A. Jones et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania

(2009) Samira S Valvassori et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

Calcium signaling in neurodegeneration

(2009) Philippe Marambaud et al.   Molecular Neurodegeneration

The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic–ischemic brain damage in mice is mediated by CB2 and adenosine receptors

(2009) A. Castillo et al.   NEUROBIOLOGY OF DISEASE

Practice Parameter update: The care of the patient with amyotrophic lateral sclerosis: Multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology

(2009) R. G. Miller et al.   NEUROLOGY

The Nonpsychotropic Cannabinoid Cannabidiol Modulates and Directly Activates Alpha-1 and Alpha-1-Beta Glycine Receptor Function

(2009) Jörg Ahrens et al.   PHARMACOLOGY

Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases

(2009) Todd E Golde et al.   Alzheimers Research & Therapy

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis

(2008) Celia J. A. Morgan et al.   BRITISH JOURNAL OF PSYCHIATRY

Mechanisms of neurodegeneration in Huntington’s disease

(2008) Joana M. Gil et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3

(2008) Raphael Rozenfeld et al.   FASEB JOURNAL

Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor γ and nuclear factor-κB in macrophages

(2008) Brian M. Necela et al.   IMMUNOLOGY

Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats

(2008) Marcelo H. Napimoga et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of Recombinant Human T-type Calcium Channels by Δ9-Tetrahydrocannabinol and Cannabidiol

(2008) Hamish Redmond Ross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPV2 Is Activated by Cannabidiol and Mediates CGRP Release in Cultured Rat Dorsal Root Ganglion Neurons

(2008) N. Qin et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Cannabidiol for the treatment of psychosis in Parkinson’s disease

(2008) AW Zuardi et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders

(2008) Caterina Scuderi et al.   PHYTOTHERAPY RESEARCH

Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats

(2008) Alline Cristina Campos et al.   PSYCHOPHARMACOLOGY

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression

(2007) G Esposito et al.   BRITISH JOURNAL OF PHARMACOLOGY

5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid

(2007) P. Massi et al.   JOURNAL OF NEUROCHEMISTRY

Cannabidiol-induced apoptosis in primary lymphocytes is associated with oxidative stress-dependent activation of caspase-8

(2007) Hsin-Ying Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Intrathecal treatment with σ1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice

(2006) Hyun-Woo Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY