Cannabinoid Ligands Targeting TRP Channels

TRP Channels as Novel Targets for Endogenous Ligands: Focus on Endocannabinoids and Nociceptive Signalling

(2018) Maksim V. Storozhuk et al.   Current Neuropharmacology

Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12

(2018) Paula Morales et al.   DRUG METABOLISM REVIEWS

A TRP channel trio mediates acute noxious heat sensing

(2018) Ine Vandewauw et al.   NATURE

Cannabinoid receptors and TRPA1 on neuroprotection in a model of retinal ischemia

(2017) D.S.M. Araújo et al.   EXPERIMENTAL EYE RESEARCH

The cannabinoid system and pain

(2017) Stephen G. Woodhams et al.   NEUROPHARMACOLOGY

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity

(2017) Marjolein Soethoudt et al.   Nature Communications

The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels

(2015) Stefania Petrosino et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor

(2015) R B Laprairie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis

(2015) Torsten Lowin et al.   ARTHRITIS RESEARCH & THERAPY

TRP Channel Cannabinoid Receptors in Skin Sensation, Homeostasis, and Inflammation

(2014) Michael J. Caterina   ACS Chemical Neuroscience

Nonpsychotropic Plant Cannabinoids, Cannabidivarin (CBDV) and Cannabidiol (CBD), Activate and Desensitize Transient Receptor Potential Vanilloid 1 (TRPV1) Channels in Vitro: Potential for the Treatment of Neuronal Hyperexcitability

(2014) Fabio Arturo Iannotti et al.   ACS Chemical Neuroscience

Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation

(2014) Siham Raboune et al.   Frontiers in Cellular Neuroscience

Ligand determinants of fatty acid activation of the pronociceptive ion channel TRPA1

(2014) William John Redmond et al.   PeerJ

Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1receptor-independent mechanism

(2013) T D M Hill et al.   BRITISH JOURNAL OF PHARMACOLOGY

The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

(2013) B Romano et al.   BRITISH JOURNAL OF PHARMACOLOGY

What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?

(2013) Alex Perálvarez-Marín et al.   FEBS Journal

Functionally Important Amino Acid Residues in the Transient Receptor Potential Vanilloid 1 (TRPV1) Ion Channel - An Overview of the Current Mutational Data

(2013) Zoltán Winter et al.   Molecular Pain

A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons

(2012) Luciano De Petrocellis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation and desensitization of TRPV1 channels in sensory neurons by the PPARα agonist palmitoylethanolamide

(2012) Paolo Ambrosino et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Endocannabinoid System and Pain

(2012) Josee Guindon et al.   CNS & Neurological Disorders-Drug Targets

Two to tango: GPCR oligomers and GPCR-TRP channel interactions in nociception

(2012) Ajay S. Yekkirala   LIFE SCIENCES

Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature

(2012) Livio Luongo et al.   PHARMACOLOGICAL RESEARCH

Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation

(2011) L. De Petrocellis et al.   Acta Physiologica

The thermo-TRP ion channel family: properties and therapeutic implications

(2011) Laura Vay et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPV4 Agonists and Antagonists

(2011) Fabien Vincent et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Desensitization of Transient Receptor Potential Ankyrin 1 (TRPA1) by the TRP Vanilloid 1-Selective Cannabinoid Arachidonoyl-2 Chloroethanolamine

(2011) N. B. Ruparel et al.   MOLECULAR PHARMACOLOGY

N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity

(2011) Luciano De Petrocellis et al.   PHARMACOLOGICAL RESEARCH

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Effects of cannabinoids and cannabinoid-enrichedCannabisextracts on TRP channels and endocannabinoid metabolic enzymes

(2010) Luciano De Petrocellis et al.   BRITISH JOURNAL OF PHARMACOLOGY

The endovanilloid/endocannabinoid system in human osteoclasts: Possible involvement in bone formation and resorption

(2008) F. Rossi et al.   BONE

Cannabinoids Desensitize Capsaicin and Mustard Oil Responses in Sensory Neurons via TRPA1 Activation

(2008) A. N. Akopian et al.   JOURNAL OF NEUROSCIENCE

TRPV2 Is Activated by Cannabidiol and Mediates CGRP Release in Cultured Rat Dorsal Root Ganglion Neurons

(2008) N. Qin et al.   JOURNAL OF NEUROSCIENCE

Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8

(2008) L. De Petrocellis et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons

(2008) Uma Anand et al.   PAIN