Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington’s Disease: Role of CB1 and CB2 Receptors

(2012) Sara Valdeolivas et al.   ACS Chemical Neuroscience

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

(2012) F M Leweke et al.   Translational Psychiatry

Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson's disease

(2011) C García et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prospects for cannabinoid therapies in basal ganglia disorders

(2011) Javier Fernández-Ruiz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice

(2011) Ewa Kozela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus

(2011) EM Rock et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9-tetrahydrocannabinol in BV-2 microglial cells

(2011) Ana Juknat et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol, a Major Phytocannabinoid, As a Potent Atypical Inhibitor for CYP2D6

(2011) S. Yamaori et al.   DRUG METABOLISM AND DISPOSITION

THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis

(2011) Jaume Sastre-Garriga et al.   Expert Review of Neurotherapeutics

Differential inhibition of human cytochrome P450 2A6 and 2B6 by major phytocannabinoids

(2011) Satoshi Yamaori et al.   Forensic Toxicology

Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death

(2011) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study

(2011) Lourdes Ruiz-Valdepeñas et al.   Journal of Neuroinflammation

Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease

(2011) Onintza Sagredo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: Role of phenolic hydroxyl groups in the resorcinol moiety

(2011) Satoshi Yamaori et al.   LIFE SCIENCES

Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease

(2011) A. M. Martin-Moreno et al.   MOLECULAR PHARMACOLOGY

Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients

(2011) Mateus M Bergamaschi et al.   NEUROPSYCHOPHARMACOLOGY

Cannabidiol-treated Rats Exhibited Higher Motor Score After Cryogenic Spinal Cord Injury

(2011) Marcelo Kwiatkoski et al.   NEUROTOXICITY RESEARCH

Cannabidiol Reduces Brain Damage and Improves Functional Recovery After Acute Hypoxia-Ischemia in Newborn Pigs

(2011) Hector Lafuente et al.   PEDIATRIC RESEARCH

Phytocannabinoids as novel therapeutic agents in CNS disorders

(2011) Andrew J. Hill et al.   PHARMACOLOGY & THERAPEUTICS

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

(2011) Giuseppe Esposito et al.   PLoS One

Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews

(2011) Erin M. Rock et al.   PSYCHOPHARMACOLOGY

Cannabis with high cannabidiol content is associated with fewer psychotic experiences

(2011) Christian D. Schubart et al.   SCHIZOPHRENIA RESEARCH

Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors

(2010) Vanessa de Paula Soares et al.   BEHAVIOURAL BRAIN RESEARCH

Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes

(2010) Satoshi Yamaori et al.   BIOCHEMICAL PHARMACOLOGY

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease

(2010) Cristina Blázquez et al.   BRAIN

Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation

(2010) I Magen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice

(2010) Y Avraham et al.   BRITISH JOURNAL OF PHARMACOLOGY

Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action

(2010) Sabatino Maione et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of nausea and vomiting by cannabinoids

(2010) Linda A Parker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of cannabinoids and cannabinoid-enrichedCannabisextracts on TRP channels and endocannabinoid metabolic enzymes

(2010) Luciano De Petrocellis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study

(2010) Celia J. A. Morgan et al.   BRITISH JOURNAL OF PSYCHIATRY

Therapeutic Role of 5-HT1A Receptors in The Treatment of Schizophrenia and Parkinson's Disease

(2010) Yukihiro Ohno   CNS Neuroscience & Therapeutics

The endocannabinoid system as a target for the treatment of neuronal damage

(2010) Javier Fernández-Ruiz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Huntington's disease: progress toward effective disease-modifying treatments and a cure

(2010) C. D. Johnson et al.   HUMAN MOLECULAR GENETICS

The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3A Receptor-Mediated Currents in Xenopus laevis Oocytes

(2010) K. H. Yang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors

(2010) Felipe V. Gomes et al.   PSYCHOPHARMACOLOGY

Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity

(2009) Javier Palazuelos et al.   BRAIN

The endocannabinoid system as a target for the treatment of motor dysfunction

(2009) Javier Fernández-Ruiz   BRITISH JOURNAL OF PHARMACOLOGY

5-HT1Areceptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats

(2009) Leonardo B.M. Resstel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors

(2009) TV Zanelati et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol: A Promising Drug for Neurodegenerative Disorders?

(2009) Teresa Iuvone et al.   CNS Neuroscience & Therapeutics

Cannabidiol-2',6'-Dimethyl Ether, a Cannabidiol Derivative, Is a Highly Potent and Selective 15-Lipoxygenase Inhibitor

(2009) S. Takeda et al.   DRUG METABOLISM AND DISPOSITION

Cannabinoid CB2receptor agonists protect the striatum against malonate toxicity: Relevance for Huntington's disease

(2009) Onintza Sagredo et al.   GLIA

Cannabinoid activation of peroxisome proliferator-activated receptors: Potential for modulation of inflammatory disease

(2009) S.E. O'Sullivan et al.   IMMUNOBIOLOGY

Δ9-Tetrahydrocannabinol and cannabidiol modulate mitogen-induced tryptophan degradation and neopterin formation in peripheral blood mononuclear cells in vitro

(2009) Marcel Jenny et al.   JOURNAL OF NEUROIMMUNOLOGY

The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic–ischemic brain damage in mice is mediated by CB2 and adenosine receptors

(2009) A. Castillo et al.   NEUROBIOLOGY OF DISEASE

The Nonpsychotropic Cannabinoid Cannabidiol Modulates and Directly Activates Alpha-1 and Alpha-1-Beta Glycine Receptor Function

(2009) Jörg Ahrens et al.   PHARMACOLOGY

Inhibition of Recombinant Human T-type Calcium Channels by Δ9-Tetrahydrocannabinol and Cannabidiol

(2008) Hamish Redmond Ross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of reactive oxygen species during mouse hepatic microsomal metabolism of cannabidiol and cannabidiol hydroxy-quinone

(2008) Noriyuki Usami et al.   LIFE SCIENCES

Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB1receptors and fatty acid amide hydrolase

(2008) d. de filippis et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Striatal 5-HT1A receptor stimulation reduces D1 receptor-induced dyskinesia and improves movement in the hemiparkinsonian rat

(2008) Kristin B. Dupre et al.   NEUROPHARMACOLOGY

Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets

(2008) Francisco J Alvarez et al.   PEDIATRIC RESEARCH

Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats

(2008) Alline Cristina Campos et al.   PSYCHOPHARMACOLOGY

The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin

(2007) R G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression

(2007) G Esposito et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

(2007) A Thomas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol arrests onset of autoimmune diabetes in NOD mice

(2007) Lola Weiss et al.   NEUROPHARMACOLOGY