Journal
ANNUAL REVIEW OF NEUROSCIENCE
Volume 31, Issue -, Pages 247-269Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.neuro.30.051606.094313
Keywords
myelin; demyelination; axonal degeneration; brain atrophy; cortical pathology; axon-glial interactions
Categories
Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS038667, R01NS035058] Funding Source: NIH RePORTER
- NINDS NIH HHS [R01 NS35058, P01 NS38667] Funding Source: Medline
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Multiple sclerosis (MS) is an inflammatory-mediated demyelinating disease of the human central nervous system. The clinical disease course is variable, usually starts with reversible episodes of neurological disability in the third or fourth decade of life, and transforms into a disease of continuous and irreversible neurological decline by the sixth or seventh decade. We review data that support neurodegeneration as the major cause of irreversible neurological disability in MS patients. We question whether inflammatory demyelination is primary or secondary in the disease process and discuss the challenges of elucidating the cause of MS and developing therapies that will delay or prevent the irreversible and progressive neurological decline that most MS patients endure.
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