Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system

Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

(2018) Antonio Cuadrado et al.   Redox Biology

Can Co-Activation of Nrf2 and Neurotrophic Signaling Pathway Slow Alzheimer’s Disease?

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators

(2017) Jill H Fowler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Progress in brain targeting drug delivery system by nasal route

(2017) Abdur Rauf Khan et al.   JOURNAL OF CONTROLLED RELEASE

Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease

(2017) Athanassios Fragoulis et al.   Redox Biology

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

(2017) Marta Pajares et al.   Redox Biology

Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm

(2016) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydrogen sulfide ameliorates learning memory impairment in APP/PS1 transgenic mice: A novel mechanism mediated by the activation of Nrf2

(2016) Yuangui Liu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR

(2016) Vishruti Makani et al.   PLoS One

Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer’s disease models

(2016) Stuart A Lipton et al.   Cell Death & Disease

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD)

(2015) Akira Nakajima et al.   BEHAVIOURAL BRAIN RESEARCH

Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease

(2015) Kurt R. Stover et al.   BEHAVIOURAL BRAIN RESEARCH

PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis

(2015) Hayley Mylroie et al.   CARDIOVASCULAR RESEARCH

FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation

(2015) Jih-Ing Chuang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy

(2015) Andrii Domanskyi et al.   HUMAN GENE THERAPY

Nonpeptide neurotrophic agents useful in the treatment of neurodegenerative diseases such as Alzheimer's disease

(2015) Masaaki Akagi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

Systemic administration of fibroblast growth factor-2 (FGF2) reduces BACE1 expression and amyloid pathology in APP23 mice

(2015) Loukia Katsouri et al.   NEUROBIOLOGY OF AGING

Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy

(2015) Gururaj Joshi et al.   NEUROBIOLOGY OF AGING

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Gracilins: Spongionella-derived promising compounds for Alzheimer disease

(2015) Marta Leirós et al.   NEUROPHARMACOLOGY

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

(2015) Karen F.S. Bell et al.   Nature Communications

Peptide Therapeutics in Neurodegenerative Disorders

(2014) Shashi Tiwari et al.   CURRENT MEDICINAL CHEMISTRY

Potential Therapeutic Drugs and Methods for the Treatment of Amyotrophic Lateral Sclerosis

(2014) G. Yacila et al.   CURRENT MEDICINAL CHEMISTRY

Cytotoxic Effect of p-Coumaric Acid on Neuroblastoma, N2a Cell via Generation of Reactive Oxygen Species Leading to Dysfunction of Mitochondria Inducing Apoptosis and Autophagy

(2014) S. Shailasree et al.   MOLECULAR NEUROBIOLOGY

Intrinsic Connectivity Identifies the Hippocampus as a Main Crossroad between Alzheimer’s and Semantic Dementia-Targeted Networks

(2014) Renaud La Joie et al.   NEURON

Gap43 Transcription Modulation in the Adult Brain Depends on Sensory Activity and Synaptic Cooperation

(2014) Nicole Rosskothen-Kuhl et al.   PLoS One

Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice

(2013) Yanyan Zhou et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Neuropep-1 ameliorates learning and memory deficits in an Alzheimer's disease mouse model, increases brain-derived neurotrophic factor expression in the brain, and causes reduction of amyloid beta plaques

(2013) Min-Kyoo Shin et al.   NEUROBIOLOGY OF AGING

Dual-energy precursor and nuclear erythroid–related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species

(2013) Debolina Ghosh et al.   NEUROBIOLOGY OF AGING

NRF2-regulation in brain health and disease: Implication of cerebral inflammation

(2013) Mats Sandberg et al.   NEUROPHARMACOLOGY

Whole body exposure to 2.4GHz WIFI signals: Effects on cognitive impairment in adult triple transgenic mouse models of Alzheimer's disease (3xTg-AD)

(2012) Sana Banaceur et al.   BEHAVIOURAL BRAIN RESEARCH

Inhibition of Phosphorylation of JNK Suppresses Aβ-Induced ER Stress and Upregulates Prosurvival Mitochondrial Proteins in Rat Hippocampus

(2012) Parvin Yenki et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis

(2012) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanism of Chemical Activation of Nrf2

(2012) Yun Li et al.   PLoS One

Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

(2012) Meijuan Zhang et al.   PROGRESS IN NEUROBIOLOGY

An experimental rat model of sporadic Alzheimer’s disease and rescue of cognitive impairment with a neurotrophic peptide

(2011) Silvia Bolognin et al.   ACTA NEUROPATHOLOGICA

Opportunities and challenges in developing Alzheimer disease therapeutics

(2011) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

(2011) Arie Neymotin et al.   FREE RADICAL BIOLOGY AND MEDICINE

GSK-3α/β kinases and amyloid production in vivo

(2011) Tomasz Jaworski et al.   NATURE

FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders

(2011) T. Kiyota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice

(2010) Julie Blanchard et al.   ACTA NEUROPATHOLOGICA

Methylene Blue Reduces Aβ Levels and Rescues Early Cognitive Deficit by Increasing Proteasome Activity

(2010) David X. Medina et al.   BRAIN PATHOLOGY

Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure

(2010) Jenna C. Carroll et al.   BRAIN RESEARCH

Fibroblast growth factor 9 upregulates heme oxygenase-1 and γ-glutamylcysteine synthetase expression to protect neurons from 1-methyl-4-phenylpyridinium toxicity

(2010) Jui-Yen Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

(2010) Cliona Stack et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ciliary Neurotrophic Factor Cell-Based Delivery Prevents Synaptic Impairment and Improves Memory in Mouse Models of Alzheimer's Disease

(2010) P. Garcia et al.   JOURNAL OF NEUROSCIENCE

L-3-n-Butylphthalide Improves Cognitive Impairment and Reduces Amyloid-  in a Transgenic Model of Alzheimer's Disease

(2010) Y. Peng et al.   JOURNAL OF NEUROSCIENCE

Chemical Biology of Peroxynitrite: Kinetics, Diffusion, and Radicals

(2009) Gerardo Ferrer-Sueta et al.   ACS Chemical Biology

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   JOURNAL OF NEUROCHEMISTRY

Intranasal delivery to the central nervous system: Mechanisms and experimental considerations

(2009) Shyeilla V. Dhuria et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

(2009) K. Kanninen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin

(2009) Jaime Kapitulnik et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

(2008) Marcus J. Calkins et al.   ANTIOXIDANTS & REDOX SIGNALING

Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease.

(2008) Susanna Pietropaolo et al.   BEHAVIORAL NEUROSCIENCE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Glutaredoxin systems

(2008) Christopher Horst Lillig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

(2008) Chiho Hirata-Fukae et al.   BRAIN RESEARCH

Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice

(2008) Ann C. McKee et al.   BRAIN RESEARCH

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

(2008) Rosa Resende et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

(2008) Katja Kanninen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Carboxypeptidase E Cytoplasmic Tail-Driven Vesicle Transport Is Key for Activity-Dependent Secretion of Peptide Hormones

(2008) Joshua J. Park et al.   MOLECULAR ENDOCRINOLOGY

Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-β and Interleukin-4

(2008) Maria E Frazer et al.   MOLECULAR THERAPY