A longer and healthier life with TOR down-regulation: genetics and drugs: Figure 1

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

RAG GTPases in nutrient-mediated TOR signaling pathway

(2011) Eunjung Kim et al.   CELL CYCLE

Growth stimulation leads to cellular senescence when the cell cycle is blocked

(2010) Zoya N. Demidenko et al.   CELL CYCLE

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Stressin' Sestrins take an aging fight

(2010) Andrei V. Budanov et al.   EMBO Molecular Medicine

TOR on the brain

(2010) Michael G. Garelick et al.   EXPERIMENTAL GERONTOLOGY

Functions and regulation of the 70kDa ribosomal S6 kinases

(2010) Tim R. Fenton et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Can autophagy promote longevity?

(2010) Frank Madeo et al.   NATURE CELL BIOLOGY

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

(2010) C A Sparks et al.   ONCOGENE

TOR and ageing: a complex pathway for a complex process

(2010) M. A. McCormick et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Translational responses to growth factors and stress

(2009) Megan Cully et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size

(2009) Thomas Porstmann et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

mTOR and the control of whole body metabolism

(2009) Pazit Polak et al.   CURRENT OPINION IN CELL BIOLOGY

TOR-dependent control of autophagy: biting the hand that feeds

(2009) Thomas P Neufeld   CURRENT OPINION IN CELL BIOLOGY

Cell Stress and Aging: New Emphasis on Multiplex Resistance Mechanisms

(2009) R. A. Miller   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A metabolic switch to memory

(2009) Martin Prlic et al.   NATURE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

Immune Regulation by Rapamycin: Moving Beyond T Cells

(2009) M. R. Janes et al.   Science Signaling

The Pharmacology of mTOR Inhibition

(2009) D. A. Guertin et al.   Science Signaling

TOR complex 2: a signaling pathway of its own

(2009) Nadine Cybulski et al.   TRENDS IN BIOCHEMICAL SCIENCES

The multiple facets of mTOR in immunity

(2009) Thomas Weichhart et al.   TRENDS IN IMMUNOLOGY

Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction

(2008) William Mair et al.   Annual Review of Biochemistry

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

Translational control of the innate immune response through IRF-7

(2008) Rodney Colina et al.   NATURE

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans

(2008) M. C. Wang et al.   SCIENCE