Lipophilic statins antagonistically alter the major epithelial-to-mesenchymal transition signaling pathways in breast cancer stem-like cells via inhibition of the mevalonate pathway

Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis

(2016) Wantae Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Simvastatin blocks TGF-β1-induced epithelial-mesenchymal transition in human prostate cancer cells

(2016) FENG XIE et al.   Oncology Letters

Statins could be new treatment option in women with oestrogen receptor positive breast cancer

(2016) Zosia Kmietowicz   BMJ-British Medical Journal

Statins could be new treatment option in women with oestrogen receptor positive breast cancer

(2016) Zosia Kmietowicz   BMJ-British Medical Journal

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

The Effect of Statin on Epithelial-Mesenchymal Transition in Peritoneal Mesothelial Cells

(2014) Tae Ik Chang et al.   PLoS One

Cholesterol and breast cancer pathophysiology

(2014) Erik R. Nelson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

TargetHunter: An In Silico Target Identification Tool for Predicting Therapeutic Potential of Small Organic Molecules Based on Chemogenomic Database

(2013) Lirong Wang et al.   AAPS Journal

Statin induces inhibition of triple negative breast cancer (TNBC) cells via PI3K pathway

(2013) Yeon Hee Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deadly crosstalk: Notch signaling at the intersection of EMT and cancer stem cells

(2013) Ingrid Espinoza et al.   CANCER LETTERS

Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B

(2013) Shinichiro Kato et al.   CANCER SCIENCE

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treating Breast Cancer in the 21st Century: Emerging Biological Therapies

(2013) Gabriel Tinoco et al.   Journal of Cancer

Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction

(2012) Jian Ye et al.   BMC BIOINFORMATICS

Breast cancer stem cells

(2012) Marco A. Velasco-Velázquez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target

(2012) Christophe Ginestier et al.   STEM CELLS

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Treatment with high-dose simvastatin inhibits geranylgeranylation in AML blast cells in a subset of AML patients

(2011) Karen van der Weide et al.   EXPERIMENTAL HEMATOLOGY

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

(2011) Bin Zhao et al.   NATURE CELL BIOLOGY

Expression and regulation mechanisms of Sonic Hedgehog in breast cancer

(2010) Wei Cui et al.   CANCER SCIENCE

β-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis

(2010) F. Klemm et al.   CARCINOGENESIS

The Role of Notch Signaling Pathway in Epithelial-Mesenchymal Transition (EMT) During Development and Tumor Aggressiveness

(2010) Zhiwei Wang et al.   CURRENT DRUG TARGETS

Statins and Breast Cancer: May Matrix Metalloproteinase be the Missing Link

(2009) Ferdinando Mannello et al.   CANCER INVESTIGATION

Statins, stem cells, and cancer

(2009) Kalamegam Gauthaman et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data

(2009) J. M. Ruijter et al.   NUCLEIC ACIDS RESEARCH

Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway

(2008) Jian Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Hippo–YAP pathway: new connections between regulation of organ size and cancer

(2008) Bin Zhao et al.   CURRENT OPINION IN CELL BIOLOGY

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simvastatin Increases Notch Signaling Activity and Promotes Arteriogenesis After Stroke

(2008) Alex Zacharek et al.   STROKE

Simvastatin induces apoptosis in human breast cancer cells in a NFκB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa

(2007) Mikael Åberg et al.   THROMBOSIS RESEARCH