Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

(2015) Chunming Cheng et al.   CANCER CELL

Activated α2-Macroglobulin Binding to Human Prostate Cancer Cells Triggers Insulin-like Responses

(2015) Uma Kant Misra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

(2015) S J H Ricoult et al.   ONCOGENE

Silibinin inhibits aberrant lipid metabolism, proliferation and emergence of androgen-independence in prostate cancer cells via primarily targeting the sterol response element binding protein 1

(2015) Dhanya K. Nambiar et al.   Oncotarget

Sterol Regulatory Element-binding Protein (SREBP) Cleavage Regulates Golgi-to-Endoplasmic Reticulum Recycling of SREBP Cleavage-activating Protein (SCAP)

(2014) Wei Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling

(2014) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity

(2013) K. J. Williams et al.   CANCER RESEARCH

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products

(2012) James R. Krycer et al.   BIOCHEMICAL JOURNAL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals

(2012) Young-Ah Moon et al.   Cell Metabolism

Expanding Roles for SREBP in Metabolism

(2012) Wei Shao et al.   Cell Metabolism

A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP

(2009) Shinji Kamisuki et al.   CHEMISTRY & BIOLOGY

Degradation of Sterol Regulatory Element-binding Protein Precursor Requires the Endoplasmic Reticulum-associated Degradation Components Ubc7 and Hrd1 in Fission Yeast

(2009) Bridget T. Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals

(2008) J. L. Hawkins et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS