Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma

Cancer statistics, 2016

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Cancer treatment and survivorship statistics, 2016

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EMT: 2016

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Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

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Could drugs inhibiting the mevalonate pathway also target cancer stem cells?

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Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells

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ZEB1 drives epithelial-to-mesenchymal transition in lung cancer

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Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis

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Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

GGPPS-mediated Rab27A geranylgeranylation regulates β cell dysfunction during type 2 diabetes development by affecting insulin granule docked pool formation

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The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb-mTORC1 signalling and leads to chronic heart failure

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Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation

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Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

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GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis

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In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells

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Molecular mechanisms of epithelial–mesenchymal transition

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Novel prospects of statins as therapeutic agents in cancer

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Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease

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Targeting EMT in cancer: opportunities for pharmacological intervention

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Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection

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The Intermediate Enzymes of Isoprenoid Metabolism as Anticancer Targets

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Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression

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Cigarette Smoke–Induced Pulmonary Inflammatory Responses Are Mediated by EGR-1/GGPPS/MAPK Signaling

(2011) Ning Shen et al.   AMERICAN JOURNAL OF PATHOLOGY

GGPPS, a New EGR-1 Target Gene, Reactivates ERK 1/2 Signaling through Increasing Ras Prenylation

(2011) Ning Shen et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas

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An Early Response Transcription Factor, Egr-1, Enhances Insulin Resistance in Type 2 Diabetes with Chronic Hyperinsulinism

(2011) Ning Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration

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Gene Expression Signature of Cigarette Smoking and Its Role in Lung Adenocarcinoma Development and Survival

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