Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells

Association between nucleos(t)ide analog and tumor recurrence in hepatitis B virus-related hepatocellular carcinoma after radiofrequency ablation

(2015) Teng-Yu Lee et al.   HEPATOLOGY

Association of Nucleos(t)ide Analogue Therapy With Reduced Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B—A Nationwide Cohort Study

(2014) Chun-Ying Wu et al.   GASTROENTEROLOGY

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

(2014) Gautam Sethi et al.   Molecular Cancer

The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase

(2013) Agata Maciejak et al.   BMC BIOTECHNOLOGY

STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells

(2013) Zheng Wei et al.   CELLULAR SIGNALLING

Statin use and risk of hepatocellular carcinoma

(2013) Shih-Wei Lai et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Simvastatin Inhibits Renal Cancer Cell Growth and Metastasis via AKT/mTOR, ERK and JAK2/STAT3 Pathway

(2013) Zhiqing Fang et al.   PLoS One

Stat3 induces oncogenic Skp2 expression in human cervical carcinoma cells

(2012) Hanhui Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Why do results conflict regarding the prognostic value of the methylation status in colon cancers? the role of the preservation method

(2012) Benjamin Tournier et al.   BMC CANCER

Prodigiosin down-regulates SKP2 to induce p27KIP1 stabilization and antiproliferation in human lung adenocarcinoma cells

(2012) Hsin-Ying Hsieh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway

(2012) Archana Gopalan et al.   CANCER LETTERS

Specific Small Molecule Inhibitors of Skp2-Mediated p27 Degradation

(2012) Lily Wu et al.   CHEMISTRY & BIOLOGY

Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies

(2012) Hsiao-Ping Chen et al.   GUT

Virtual Grief

(2012) David Wu   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Potential for statins in the chemoprevention and management of hepatocellular carcinoma

(2012) Amedeo Lonardo et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma

(2011) Masashi Yanae et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of AMPK-dependent autophagy enhances in vitro antiglioma effect of simvastatin

(2011) Maja Misirkic et al.   PHARMACOLOGICAL RESEARCH

Role of T198 Modification in the Regulation of p27Kip1 Protein Stability and Function

(2011) Monica Schiappacassi et al.   PLoS One

Inhibition of Autophagy Enhances Anticancer Effects of Atorvastatin in Digestive Malignancies

(2010) P.-M. Yang et al.   CANCER RESEARCH

Ubiquitylation and proteasomal degradation of the p21Cip1, p27Kip1and p57Kip2CDK inhibitors

(2010) Zhimin Lu et al.   CELL CYCLE

Simvastatin induces derepression of PTEN expression via NFκB to inhibit breast cancer cell growth

(2010) Nayana Ghosh-Choudhury et al.   CELLULAR SIGNALLING

Effect of statin therapy on colorectal cancer

(2010) M. Bardou et al.   GUT

Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells

(2010) Relja   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Anticancer Efficacy of Simvastatin on Prostate Cancer Cells and Tumor Xenografts Is Associated with Inhibition of Akt and Reduced Prostate-Specific Antigen Expression

(2010) S. T. Kochuparambil et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Overexpression of PPARγ can down-regulate Skp2 expression in MDA-MB-231 breast tumor cells

(2010) Jie Meng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Dysregulation of the mevalonate pathway promotes transformation

(2010) J. W. Clendening et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac-specific Deletion of LKB1 Leads to Hypertrophy and Dysfunction

(2009) Yasumasa Ikeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Rac1 by Simvastatin in Endothelial Cells

(2009) Ruqin Kou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy

(2008) Q. Chen et al.   BLOOD

Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN

(2008) Xiaoxia Sun et al.   CANCER LETTERS

The High-Mobility Group A1a/Signal Transducer and Activator of Transcription-3 Axis: An Achilles Heel for Hematopoietic Malignancies?

(2008) J. Hillion et al.   CANCER RESEARCH

Reactive Nitrogen Species Is Required for the Activation of the AMP-activated Protein Kinase by Statinin Vivo

(2008) Hyoung Chul Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY