Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer’s Disease

Rescue of long-range circuit dysfunction in Alzheimer's disease models

(2015) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation

(2015) Bryce A Mander et al.   NATURE NEUROSCIENCE

Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease

(2015) Kaoru Yamamoto et al.   Cell Reports

Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease

(2013) Shuko Takeda et al.   FASEB JOURNAL

Layer-specific excitatory circuits differentially control recurrent network dynamics in the neocortex

(2013) Riccardo Beltramo et al.   NATURE NEUROSCIENCE

Optogenetic-mediated increases in in vivo spontaneous activity disrupt pool-specific but not dorsal-ventral motoneuron pathfinding

(2013) K. V. Kastanenka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Interneuron-mediated inhibition synchronizes neuronal activity during slow oscillation

(2012) Jen-Yung Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Concurrent Impairments in Sleep and Memory in Amnestic Mild Cognitive Impairment

(2012) Carmen E. Westerberg et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease

(2012) Christine Grienberger et al.   Nature Communications

Characterization of Oligomer Formation of Amyloid-β Peptide Using a Split-luciferase Complementation Assay

(2011) Tadafumi Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Slow and fast rhythms generated in the cerebral cortex of the anesthetized mouse

(2011) Marcel Ruiz-Mejias et al.   JOURNAL OF NEUROPHYSIOLOGY

Evidence of Altered Posteromedial Cortical fMRI Activity in Subjects at Risk for Alzheimer Disease

(2010) Maija Pihlajamäki et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

In Vivo Activation of Channelrhodopsin-2 Reveals That Normal Patterns of Spontaneous Activity Are Required for Motoneuron Guidance and Maintenance of Guidance Molecules

(2010) K. V. Kastanenka et al.   JOURNAL OF NEUROSCIENCE

Mirrored Bilateral Slow-Wave Cortical Activity within Local Circuits Revealed by Fast Bihemispheric Voltage-Sensitive Dye Imaging in Anesthetized and Awake Mice

(2010) M. H. Mohajerani et al.   JOURNAL OF NEUROSCIENCE

Amyloid   Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

(2010) H.-Y. Wu et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired Medial Temporal Repetition Suppression is Related to Failure of Parietal Deactivation in Alzheimer Disease

(2008) Maija Pihlajamäki et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE