Article
Geriatrics & Gerontology
Katja Neumann, Matthias Guenther, Emrah Duezel, Stefanie Schreiber
Summary: This pilot study investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). The results showed that there were decreases in cerebral blood flow (CBF) and increases in arterial transit time (ATT) with increasing CSVD severity in patients, indicating impaired perfusion. Additionally, patients with CSVD had longer effective T1-relaxation time (T1eff), suggesting impaired clearance. The T1eff of white matter (WM) was primarily associated with CSVD burden, while lobar lacunes and cerebral microbleeds (CMBs) also contributed to this relation.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jayanarayanan Sadanandan, Monica Sathyanesan, Yutong Liu, Neeraj K. Tiwari, Samuel S. Newton
Summary: Cerebral hypoperfusion has negative effects on cognitive function and increases the risk of neuropsychiatric disorders. Erythropoietin (EPO) has been shown to improve cognitive function, but its use is limited due to its erythropoietic activity. However, carbamoylated erythropoietin (CEPO), a non-erythropoietic derivative of EPO, has similar neurotrophic and behavioral effects without affecting hematocrit levels. Our study reveals that CEPO can increase blood perfusion through neurotransmission and vasodilation, without affecting tight junction integrity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Peter M. Maloca, Silvia Feu-Basilio, Julia Schottenhamml, Philippe Valmaggia, Hendrik P. N. Scholl, Josep Rosines-Fonoll, Sara Marin-Martinez, Nadja Inglin, Michael Reich, Clemens Lange, Catherine Egan, Sandrine Zweifel, Adnan Tufail, Richard F. Spaide, Javier Zarranz-Ventura
Summary: This study is the first to investigate three-dimensional vascular parameters, specifically vessel surface area, in a population using OCTA. It found that axial length has the strongest effect on OCTA vessel surface area, with a slight negative correlation with age.
SCIENTIFIC REPORTS
(2022)
Article
Physics, Fluids & Plasmas
Peter Olsson
Summary: In this study, overdamped simulations were conducted in a simple model of jamming to explore the finite size dependence of various quantities, including the relaxation time obtained from the relaxation of energy and the pressure equivalent of shear viscosity. The study found that the choice of starting configurations had a significant impact on the determination of critical divergence, and the claimed ln N dependence of the relaxation time was not as problematic as previously thought. Additionally, analyses of particle relaxation times provided useful histograms and averages for further analysis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicolas J. Guehl, Maeva Dhaynaut, Bernard J. Hanseeuw, Sung-Hyun Moon, Cristina Lois, Emma Thibault, Jessie Fanglu Fu, Julie C. Price, Keith A. Johnson, Georges El Fakhri, Marc D. Normandin
Summary: This study investigated the use of [18F]MK6240 to derive a useful index of cerebral perfusion. The results showed that early-phase brain images provided valuable information about cerebral perfusion and were highly consistent with [11C]PiB results. Therefore, both the early and late phases of [18F]MK6240 dynamic acquisition can offer complementary information about the pathophysiological mechanisms of the disease.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Neurosciences
Camille Taccola, Pascal Barneoud, Sylvaine Cartot-Cotton, Delphine Valente, Nathalie Schussler, Bruno Saubamea, Stephanie Chasseigneaux, Veronique Cochois, Virginie Mignon, Emmanuel Curis, Murielle Lochus, Sophie Nicolic, Agnes Dodacki, Salvatore Cisternino, Xavier Decleves, Fanchon Bourasset
Summary: The inducible p25 overexpression mouse model showed no significant alterations in brain vascular surface area and BBB physical integrity, but a 14% decrease in cerebrovascular volume in 6 weeks ON mice, possibly due to a 27% increase in collagen IV in brain capillaries. Additionally, a 17% reduction in D-glucose brain uptake was observed in 6 weeks ON p25 mice, indicating impaired BBB transport function.
Article
Clinical Neurology
Siobhan Hoscheidt, Ashley H. Sanderlin, Laura D. Baker, Youngkyoo Jung, Samuel Lockhart, Derek Kellar, Christopher Whitlow, Angela J. Hanson, Seth Friedman, Thomas Register, James B. Leverenz, Suzanne Craft
Summary: The study revealed that dietary patterns in mid-life are associated with Alzheimer's disease risk, and individuals with different cognitive statuses respond differently to different diets.
ALZHEIMERS & DEMENTIA
(2022)
Article
Cardiac & Cardiovascular Systems
Samuel P. Klein, Veerle De Sloovere, Geert Meyfroidt, Bart Depreitere
Summary: This study provides new insights into the quadriphasic physiology of cerebrovascular autoregulation (CA) and reveals substantial intersubject variability in the limits of CA.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Neuroimaging
Mais Al-Kawaz, Christopher Primiani, Victor Urrutia, Ferdinand Hui
Summary: The study analyzed the impact of using the RapidAI mobile application on treatment times in stroke care, showing significant reductions in key time intervals such as DGPT. The use of this application was also associated with lower post-procedure assessment scores.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Cell Biology
Ronit Shapira, Amos Gdalyahu, Irit Gottfried, Efrat Sasson, Amir Hadanny, Shai Efrati, Pablo Blinder, Uri Ashery
Summary: The study demonstrates the efficacy of hyperbaric oxygen therapy (HBOT) in reducing amyloid burden, improving cognitive function, and increasing cerebral blood flow in AD model mice.
Article
Endocrinology & Metabolism
Evelyn Lara, Nathaly Rivera, Alejandro Gonzalez-Bernal, Daniela Rojas, Daniela Lopez-Espindola, Andres Rodriguez, Carlos Escudero
Summary: This study evaluated brain microvascular perfusion and microvascular reactivity in offspring born to mice with preeclampsia-like syndrome. It found that the offspring exhibited impaired brain perfusion and microvascular reactivity, particularly in female mice, associated with differential expression of angiogenic proteins in the brain tissue.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Manabu Inoue, Takeshi Yoshimoto, Kanta Tanaka, Junpei Koge, Masayuki Shiozawa, Tatsuya Nishii, Yasutoshi Ohta, Tetsuya Fukuda, Tetsu Satow, Hiroharu Kataoka, Hiroshi Yamagami, Masafumi Ihara, Masatoshi Koga, Michael Mlynash, Gregory W. Albers, Kazunori Toyoda
Summary: A retrospective study compared early and late presenting patients with large vessel occlusion using perfusion-weighted imaging selection, finding no significant differences in clinical and radiographic outcomes between the groups. However, the late-presenting group showed more atherothrombotic cerebral infarction, smaller hypoperfusion volume, and slower infarct growth velocity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tong Zhang, Ruowei Tang, Song Liu, Chao Chai, Yongsheng Chen, E. Mark Haacke, Shuang Xia
Summary: This study compared STAGE and hr-vwMRI for assessing MCA plaque vulnerability, finding that STAGE showed good efficiency. Patients with misery perfusion had different plaque characteristics compared to those without misery perfusion, with susceptibility and stenosis degree being independent predictors for the occurrence of misery perfusion.
EUROPEAN RADIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shoou-Jeng Yeh, Chi-Wen Lung, Yih-Kuen Jan, Fang-Chuan Kuo, Ben-Yi Liau
Summary: Cardiovascular diseases have been a leading cause of mortality in Taiwan and worldwide for decades. Detecting and preventing cardiovascular and cerebrovascular diseases is crucial. The characteristics and changes in cardiovascular and cerebrovascular systems play a significant role in disease prevention and diagnosis. Research findings show that stroke and hypertension patients have significantly higher blood pressure and cerebral blood flow compared to healthy individuals, indicating differences in cardiovascular control between these groups.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Feng Wang, Xiaofang Zhou, Ruiquan Chen, Jie Kang, Xinyi Yang, Jinzhu Lin, Fang Liu, Dairong Cao, Zhen Xing
Summary: This study aimed to compare the accuracy of relative cerebral blood volume (rCBV) and percentage signal recovery (PSR) obtained from high flip-angle dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) sequences with and without contrast agent (CA) preload for presurgical discrimination of brain glioblastoma and lymphoma.
EUROPEAN RADIOLOGY
(2023)
Article
Neurosciences
Andreas Bruns, Thomas Mueggler, Basil Kuennecke, Celine Risterucci, Eric P. Prinssen, Joseph G. Wettstein, Markus von Kienlin
Article
Medicine, Research & Experimental
Hua Jing, Claudia Weidensteiner, Wilfried Reichardt, Simone Gaedicke, Xuekai Zhu, Anca-Ligia Grosu, Hisataka Kobayashi, Gabriele Niedermann
Article
Neurosciences
Lorenzo More, Basil Kunnecke, Latefa Yekhlef, Andreas Bruns, Antonella Marte, Ernesto Fedele, Veronica Bianchi, Stefano Taverna, Silvia Gatti, Patrizia D'Adamo
Article
Oncology
Max Heckler, Nadja Osterberg, Jessica Guenzle, Nina Kristin Thiede-Stan, Wilfried Reichardt, Claudia Weidensteiner, Joseph E. Saavedra, Astrid Weyerbrock
Article
Cell Biology
Oliver H. Miller, Andreas Bruns, Imen Ben Ammar, Thomas Mueggler, Benjamin J. Hall
Article
Neurosciences
Madhurima Benekareddy, Tevye Jason Stachniak, Andreas Bruns, Frederic Knoflach, Markus von Kienlin, Basil Kunnecke, Anirvan Ghosh
BIOLOGICAL PSYCHIATRY
(2018)
Article
Psychiatry
Jamie Horder, Marija M. Petrinovic, Maria A. Mendez, Andreas Bruns, Toru Takumi, Will Spooren, Gareth J. Barker, Basil Kunnecke, Declan G. Murphy
TRANSLATIONAL PSYCHIATRY
(2018)
Article
Multidisciplinary Sciences
Marija M. Petrinovic, Georges Hankov, Aileen Schroeter, Andreas Bruns, Markus Rudin, Markus von Kienlin, Basil Kunnecke, Thomas Mueggler
SCIENTIFIC REPORTS
(2016)
Article
Chemistry, Medicinal
Patrick Schnider, Caterina Bissantz, Andreas Bruns, Cosimo Dolente, Erwin Goetschi, Roland Jakob-Roetne, Basil Kuennecke, Thomas Mueggler, Wolfgang Muster, Neil Parrott, Emmanuel Pinard, Hasane Ratni, Celine Risterucci, Mark Rogers-Evans, Markus von Kienlin, Christophe Grundschober
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Clinical Neurology
Eva M. Kesenheimer, Maria Janina Wendebourg, Matthias Weigel, Claudia Weidensteiner, Tanja Haas, Laura Richter, Laura Sander, Antal Horvath, Muhamed Barakovic, Philippe Cattin, Cristina Granziera, Oliver Bieri, Regina Schlaeger
Summary: This study aimed to develop normalization strategies for spinal cord metrics derived from rAMIRA imaging, using skull and spine-based metrics to reduce anatomical variability.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Tugba Akinci D'Antonoli, Francesco Santini, Xeni Deligianni, Meritxell Garcia Alzamora, Erich Rutz, Oliver Bieri, Reinald Brunner, Claudia Weidensteiner
Summary: The study utilized a combination of MRI fat fraction and texture analysis to differentiate affected muscles from healthy ones in cerebral palsy patients, with the combination model consistently outperforming individual models in performance.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Claudia Weidensteiner, Philipp Madoerin, Xeni Deligianni, Tanja Haas, Oliver Bieri, Tugba Akinci D'Antonoli, Katrin Bracht-Schweizer, Jacqueline Romkes, Enrico De Pieri, Francesco Santini, Erich Rutz, Reinald Brunner, Meritxell Garcia
Summary: A study of 6 pediatric CP patients undergoing MRI evaluation of the effect of BTX injections on calf muscle properties showed signal enhancement, increased T-2 values, increased FA, unchanged ADC in hyperintense ROIs, and a trend towards increased fat fraction at 12 weeks. Mean values in the reference ROIs remained stable.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Enrico De Pieri, Johannes Cip, Reinald Brunner, Claudia Weidensteiner, Nathalie Alexander
Summary: This study aimed to compare the muscle contributions to hip joint moments and muscle forces in patients with increased femoral anteversion and an internally rotated gait pattern to a control group of typically developing children. The study found that despite the patients having a comparable net hip abduction moment, their gluteus medius abductive contribution was lower compared to controls. Furthermore, if the patients were modeled to walk straight, their muscle forces would increase. These findings provide important information for understanding and improving treatment recommendations for this condition.
Article
Food Science & Technology
Reinald Brunner, Enrico De Pieri, Christian Wyss, Claudia Weidensteiner, Katrin Bracht-Schweizer, Jacqueline Romkes, Meritxell Garcia, Norine Ma, Erich Rutz
Summary: Local botulinum toxin (BTX-A, Botox (R)) injection is a standard treatment for overactive muscles in cerebral palsy patients. However, the effectiveness of BTX-A is reduced in older children, possibly due to limited muscle volume affected by the drug. This study found that injecting BTX-A into the muscles only affected 9-15% of the muscle volume, and had no significant impact on gait kinematics and kinetics. Multiple injection sites are recommended for better distribution of the drug.
