Familial Alzheimer’s disease–associated presenilin-1 alters cerebellar activity and calcium homeostasis

PHENYTOIN AND CEREBELLAR ATAXIA: NOT ALL DOWN TO TOXICITY?

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Cerebellar dysfunction in a family harboring the PSEN1 mutation co-segregating with a Cathepsin D variant p.A58V

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Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria

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Chronic Suppression of Inositol 1,4,5-Triphosphate Receptor-Mediated Calcium Signaling in Cerebellar Purkinje Cells Alleviates Pathological Phenotype in Spinocerebellar Ataxia 2 Mice

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Cerebellar Ataxia by Enhanced CaV2.1 Currents Is Alleviated by Ca2+-Dependent K+-Channel Activators in Cacna1aS218L Mutant Mice

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A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

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Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study

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PRINT - ALZHEIMER’S

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Mitochondria as sensors and regulators of calcium signalling

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Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

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Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer's disease: a retrospective cohort study

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Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

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Deposition of Hyperphosphorylated Tau in Cerebellum of PS1 E280A Alzheimer's Disease

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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

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Purkinje Cell-Specific Knockout of the Protein Phosphatase PP2B Impairs Potentiation and Cerebellar Motor Learning

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Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons

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Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

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The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

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Cerebellar ataxias

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Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

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Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

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Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

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Motor Decline in Clinically Presymptomatic Spinocerebellar Ataxia Type 2 Gene Carriers

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Amyloid-  and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

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Calcium dysregulation in Alzheimer's disease: From mechanisms to therapeutic opportunities

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Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death

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SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

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Role of Olivary Electrical Coupling in Cerebellar Motor Learning

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Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

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