Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

(2017) Shona A. Mookerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short-term starvation is a strategy to unravel the cellular capacity of oxidizing specific exogenous/endogenous substrates in mitochondria

(2017) Julianna D. Zeidler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

(2017) Nicholas B. Hastings et al.   Molecular Neurodegeneration

Brain glucose metabolism: Role of Wnt signaling in the metabolic impairment in Alzheimer’s disease

(2017) Pedro Cisternas et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Rethinking Alzheimer's Disease Therapy: Are Mitochondria the Key?

(2017) Maria Ankarcrona et al.   JOURNAL OF ALZHEIMERS DISEASE

Catalytic Coupling of Oxidative Phosphorylation, ATP Demand, and Reactive Oxygen Species Generation

(2016) Jason N. Bazil et al.   BIOPHYSICAL JOURNAL

Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species

(2016) Lorena Aguilar-Arnal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantification of the Metabolic State in Cell-Model of Parkinson’s Disease by Fluorescence Lifetime Imaging Microscopy

(2016) Sandeep Chakraborty et al.   Scientific Reports

The regulation of neuronal mitochondrial metabolism by calcium

(2015) I. Llorente-Folch et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How computational models can help unlock biological systems

(2015) G. Wayne Brodland   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

The Emerging Link betweenO-GlcNAc and Alzheimer Disease

(2014) Yanping Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

(2014) Scott A Yuzwa et al.   Molecular Neurodegeneration

Rapid Analysis of Glycolytic and Oxidative Substrate Flux of Cancer Cells in a Microplate

(2014) Lisa S. Pike Winer et al.   PLoS One

Separating NADH and NADPH fluorescence in live cells and tissues using FLIM

(2014) Thomas S. Blacker et al.   Nature Communications

A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers

(2014) Philip A. Kramer et al.   Redox Biology

Early Deficits in Glycolysis Are Specific to Striatal Neurons from a Rat Model of Huntington Disease

(2013) Caroline Gouarné et al.   PLoS One

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

Ca2+dysregulation in neurons from transgenic mice expressing mutant presenilin 2

(2012) Maulilio J. Kipanyula et al.   AGING CELL

No Consistent Bioenergetic Defects in Presynaptic Nerve Terminals Isolated from Mouse Models of Alzheimer's Disease

(2012) S. W. Choi et al.   JOURNAL OF NEUROSCIENCE

Metabolic Imaging Using Two-Photon Excited NADH Intensity and Fluorescence Lifetime Imaging

(2012) Jorge Vergen et al.   MICROSCOPY AND MICROANALYSIS

A structured approach to the study of metabolic control principles in intact and impaired mitochondria

(2012) Heinrich J. Huber et al.   Molecular BioSystems

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Investigation of Mitochondrial Dysfunction by Sequential Microplate-Based Respiration Measurements from Intact and Permeabilized Neurons

(2012) Pascaline Clerc et al.   PLoS One

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Imaging of a glucose analog, calcium and NADH in neurons and astrocytes: Dynamic responses to depolarization and sensitivity to pioglitazone

(2011) Tristano Pancani et al.   CELL CALCIUM

Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release

(2011) H. J. Huber et al.   Molecular Systems Biology

Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies

(2010) Ahmed A Heikal   Biomarkers in Medicine

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

(2009) V. Rhein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of cardiac mitochondrial Na+-Ca2+exchanger kinetics with a biophysical model of mitochondrial Ca2+handing suggests a 3: 1 stoichiometry

(2008) Ranjan K. Dash et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression of Transgenic APP mRNA Is the Key Determinant for Beta-Amyloid Deposition in PS2APP Transgenic Mice

(2008) Laurence Ozmen et al.   Neurodegenerative Diseases