Ryanodine receptors: physiological function and deregulation in Alzheimer disease

FK506 binding proteins: Cellular regulators of intracellular Ca2+ signalling

(2013) Debbi MacMillan   EUROPEAN JOURNAL OF PHARMACOLOGY

Cytotoxicity of Intracellular A 42 Amyloid Oligomers Involves Ca2+ Release from the Endoplasmic Reticulum by Stimulated Production of Inositol Trisphosphate

(2013) A. Demuro et al.   JOURNAL OF NEUROSCIENCE

A preliminary study of the whole-genome expression profile of sporadic and monogenic early-onset Alzheimer's disease

(2013) Anna Antonell et al.   NEUROBIOLOGY OF AGING

Can the Calcium Hypothesis Explain Synaptic Loss in Alzheimer's Disease?

(2013) Elena Popugaeva et al.   Neurodegenerative Diseases

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons

(2013) B. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+dysregulation in neurons from transgenic mice expressing mutant presenilin 2

(2012) Maulilio J. Kipanyula et al.   AGING CELL

Calcium leak through ryanodine receptor is involved in neuronal death induced by mutant huntingtin

(2012) Mari Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction

(2012) Xiaoping Liu et al.   CELL

Response to Shillinget al.(10.1074/jbc.M111.300491)

(2012) Ilya Bezprozvanny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+Leak Channels

(2012) Dustin Shilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca2+ leak that is impaired by FAD mutations

(2012) Hriday K. Das et al.   JOURNAL OF NEUROCHEMISTRY

Early Presynaptic and Postsynaptic Calcium Signaling Abnormalities Mask Underlying Synaptic Depression in Presymptomatic Alzheimer's Disease Mice

(2012) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Ryanodine Receptor Blockade Reduces Amyloid-  Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

(2012) B. Oules et al.   JOURNAL OF NEUROSCIENCE

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease

(2012) Linda Chami et al.   Molecular Neurodegeneration

Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

(2012) Jun Peng et al.   NEUROSCIENCE LETTERS

Stabilizing ER Ca2+ Channel Function as an Early Preventative Strategy for Alzheimer’s Disease

(2012) Shreaya Chakroborty et al.   PLoS One

Dantrolene prevents arrhythmogenic Ca2+ release in heart failure

(2011) Joshua T. Maxwell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of PKA attenuates memory deficits induced by β-amyloid (1–42), and decreases oxidative stress and NF-κB transcription factors

(2011) Bahareh Eftekharzadeh et al.   BEHAVIOURAL BRAIN RESEARCH

Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging

(2011) Daniel C. Andersson et al.   Cell Metabolism

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

(2011) Christian B. Jung et al.   EMBO Molecular Medicine

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

(2011) Sergio Casas-Tinto et al.   HUMAN MOLECULAR GENETICS

Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore

(2011) Omar Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization of the Dantrolene-binding Sequence near the FK506-binding Protein-binding Site in the Three-dimensional Structure of the Ryanodine Receptor

(2011) Ruiwu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disrupting Function of FK506-Binding Protein 1b/12.6 Induces the Ca2+-Dysregulation Aging Phenotype in Hippocampal Neurons

(2011) J. C. Gant et al.   JOURNAL OF NEUROSCIENCE

Dantrolene is neuroprotective in Huntington's disease transgenic mouse model

(2011) Xi Chen et al.   Molecular Neurodegeneration

Endoplasmic Reticulum Ca2+ Handling in Excitable Cells in Health and Disease

(2011) G. E. Stutzmann et al.   PHARMACOLOGICAL REVIEWS

Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion

(2011) Jérémy Fauconnier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early calcium dysregulation in Alzheimer’s disease: setting the stage for synaptic dysfunction

(2011) Shreaya Chakroborty et al.   Science China-Life Sciences

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Amyloid β-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF

(2010) Andrea C. Paula-Lima et al.   ANTIOXIDANTS & REDOX SIGNALING

The dysregulation of intracellular calcium in Alzheimer disease

(2010) Charlene Supnet et al.   CELL CALCIUM

Ryanodine receptor-2 upregulation and nicotine-mediated plasticity

(2010) Elena Ziviani et al.   EMBO JOURNAL

HGF suppresses high glucose-mediated oxidative stress in mesangial cells by activation of PKG and inhibition of PKA

(2010) Li Hui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardiac ryanodine receptor phosphorylation by CaM Kinase II: keeping the balance right

(2010) Susan Currie   Frontiers in Bioscience-Landmark

Role of Presenilins in Neuronal Calcium Homeostasis

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

NMDA-Mediated Ca2+ Influx Drives Aberrant Ryanodine Receptor Activation in Dendrites of Young Alzheimer's Disease Mice

(2010) I. Goussakov et al.   JOURNAL OF NEUROSCIENCE

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake

(2009) Lucia Brunello et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Up-regulation of the type 3 ryanodine receptor is neuroprotective in the TgCRND8 mouse model of Alzheimer’s disease

(2009) Charlene Supnet et al.   JOURNAL OF NEUROCHEMISTRY

Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 2

(2009) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice

(2009) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor

(2009) Shigeki Kobayashi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Presenilins are essential for regulating neurotransmitter release

(2009) Chen Zhang et al.   NATURE

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

(2009) Andrew M Bellinger et al.   NATURE MEDICINE

Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses

(2009) N. Holbro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of amyloid β on capacitive calcium entry in neural 2a cells

(2008) Ying Niu et al.   BRAIN RESEARCH BULLETIN

The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein–protein interaction

(2008) Volodya Hayrapetyan et al.   CELL CALCIUM

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

(2008) Kim N. Green et al.   JOURNAL OF CELL BIOLOGY

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

(2008) Fabrizio Trinchese et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased intraneuronal resting [Ca2+] in adult Alzheimer’s disease mice

(2008) José R. Lopez et al.   JOURNAL OF NEUROCHEMISTRY

Ischemia Enhances Activation by Ca2+ and Redox Modification of Ryanodine Receptor Channels from Rat Brain Cortex

(2008) R. Bull et al.   JOURNAL OF NEUROSCIENCE

Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 3

(2008) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β protein impairs Ca2+ release and contractility in skeletal muscle

(2008) Alexander Shtifman et al.   NEUROBIOLOGY OF AGING

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development

(2008) G. M. Elias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remodeling of ryanodine receptor complex causes "leaky" channels: A molecular mechanism for decreased exercise capacity

(2008) A. M. Bellinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

Effect of the knockdown of amyloid precursor protein on intracellular calcium increases in a neuronal cell line derived from the cerebral cortex of a trisomy 16 mouse

(2007) Guillermo Rojas et al.   EXPERIMENTAL NEUROLOGY

The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity

(2007) Volodymyr Rybalchenko et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY