Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

Neuronal hyperactivity - A key defect in Alzheimer's disease?

(2015) Marc Aurel Busche et al.   BIOESSAYS

The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials

(2014) Reisa Sperling et al.   NEURON

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Open questions for Alzheimer’s disease immunotherapy

(2014) Todd E Golde   Alzheimers Research & Therapy

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

Neutralization of Soluble, Synaptotoxic Amyloid   Species by Antibodies Is Epitope Specific

(2012) W. Zago et al.   JOURNAL OF NEUROSCIENCE

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease

(2012) Christine Grienberger et al.   Nature Communications

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Immunotherapy Reduces Vascular Amyloid-  in PDAPP Mice

(2008) S. Schroeter et al.   JOURNAL OF NEUROSCIENCE

Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease

(2008) Tara L. Spires-Jones et al.   NEUROBIOLOGY OF DISEASE

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE