Liver Steatosis, Gut-Liver Axis, Microbiome and Environmental Factors. A Never-Ending Bidirectional Cross-Talk

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

Childhood obesity, cardiovascular and liver health: a growing epidemic with age

(2020) Maria Felicia Faienza et al.   World Journal of Pediatrics

Increased Colonic Permeability and Lifestyles as Contributing Factors to Obesity and Liver Steatosis

(2020) Domenica Maria Di Palo et al.   Nutrients

Bisphenol A exposure induces gut microbiota dysbiosis and consequent activation of gut-liver axis leading to hepatic steatosis in CD-1 mice

(2020) Dan Feng et al.   ENVIRONMENTAL POLLUTION

COVID‐19 and nonalcoholic fatty liver disease: two intersecting pandemics

(2020) Piero Portincasa et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Metabolomic-based assessment reveals dysregulation of lipid profiles in human liver cells exposed to environmental obesogens

(2020) Marco E. Franco et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Role of Innate Immune Cells in Nonalcoholic Steatohepatitis

(2019) Jingjing Cai et al.   HEPATOLOGY

NASH in Lean Individuals

(2019) Ramy Younes et al.   SEMINARS IN LIVER DISEASE

Regulation of Adaptive Thermogenesis and Browning by Prebiotics and Postbiotics

(2019) Bàrbara Reynés et al.   Frontiers in Physiology

Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease

(2019) Marco Biolato et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Combined effects of ambient particulate matter exposure and a high-fat diet on oxidative stress and steatohepatitis in mice

(2019) Shibin Ding et al.   PLoS One

Fecal and blood microbiota profiles and presence of nonalcoholic fatty liver disease in obese versus lean subjects

(2019) Yeojun Yun et al.   PLoS One

Elevated Urinary Bisphenol A Levels are Associated with Nonalcoholic Fatty Liver Disease among Adults in the United States

(2019) Donghee Kim et al.   LIVER INTERNATIONAL

Total cholesterol to high-density lipoprotein cholesterol ratio is a significant predictor of nonalcoholic fatty liver: Jinchang cohort study

(2019) Xiao Yu Ren et al.   Lipids in Health and Disease

Innate immune regulatory networks in hepatic lipid metabolism

(2019) Lan Bai et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tuft cells: From the mucosa to the thymus

(2019) Shir Nevo et al.   IMMUNOLOGY LETTERS

Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease

(2019) Cheng-Maw Ho et al.   Journal of Inflammation-London

Non-alcoholic fatty liver disease in non-obese individuals: Prevalence, pathogenesis and treatment

(2019) Emilio Molina-Molina et al.   Clinics and Research in Hepatology and Gastroenterology

Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine

(2019) Annette Brandt et al.   Scientific Reports

Associations between mercury exposure and the risk of nonalcoholic fatty liver disease (NAFLD) in US adolescents

(2019) Runsen Chen et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development

(2019) Juliette Mouries et al.   JOURNAL OF HEPATOLOGY

Correlation of triglyceride to high-density lipoprotein cholesterol ratio with nonalcoholic fatty liver disease among the non-obese Chinese population with normal blood lipid levels: a retrospective cohort research

(2019) Zekai Chen et al.   Lipids in Health and Disease

Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation

(2019) Alberto Nicoletti et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The gut-liver axis in liver disease: pathophysiological basis for therapy

(2019) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Prenatal exposure to diesel exhaust PM2.5 programmed non-alcoholic fatty liver disease differently in adult male offspring of mice fed normal chow and a high-fat diet

(2019) Xiaoke Wang et al.   ENVIRONMENTAL POLLUTION

Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003–2004

(2019) Banrida Wahlang et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Could phthalates exposure contribute to the development of metabolic syndrome and liver disease in humans?

(2019) Nataša Milošević et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Emerging Molecular Targets for Treatment of Nonalcoholic Fatty Liver Disease

(2019) Ze Chen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Role of bisphenol A as environmental factor in the promotion of non-alcoholic fatty liver disease: in vitro and clinical study

(2018) M. Dallio et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease

(2018) Juan Pablo Arab et al.   Annual Review of Pathology-Mechanisms of Disease

In utero and lactational exposure to BDE-47 promotes obesity development in mouse offspring fed a high-fat diet: impaired lipid metabolism and intestinal dysbiosis

(2018) Dezhen Wang et al.   ARCHIVES OF TOXICOLOGY

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

(2018) Bjoern O. Schroeder et al.   Cell Host & Microbe

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases

(2018) Varman T. Samuel et al.   Cell Metabolism

The Natural History of Nonalcoholic Fatty Liver Disease—An Evolving View

(2018) Christina C. Lindenmeyer et al.   Clinics in Liver Disease

Nonalcoholic fatty liver disease as a sentinel marker for the development of diabetes mellitus in non-obese subjects

(2018) Soon Sun Kim et al.   DIGESTIVE AND LIVER DISEASE

Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor

(2018) Céline Lukowicz et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Dioxin-like PCB 126 increases intestinal inflammation and disrupts gut microbiota and metabolic homeostasis

(2018) Michael C. Petriello et al.   ENVIRONMENTAL POLLUTION

Exercising the hepatobiliary-gut axis. The impact of physical activity performance

(2018) Emilio Molina-Molina et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Obesity phenotypes and their paradoxical association with cardiovascular diseases

(2018) Alessandra Vecchié et al.   European Journal of Internal Medicine

Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD

(2018) Cyrielle Caussy et al.   HEPATOLOGY

Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease

(2018) Francesca Romana Ponziani et al.   HEPATOLOGY

Lipotoxicity and the gut-liver axis in NASH pathogenesis

(2018) Fabio Marra et al.   JOURNAL OF HEPATOLOGY

Type 3 regulatory T cells at the interface of symbiosis

(2018) Joo-Hong Park et al.   JOURNAL OF MICROBIOLOGY

Quality of life in patients with nonalcoholic fatty liver disease: A systematic review

(2018) Konstantinos Assimakopoulos et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Cholecystectomy: a way forward and back to metabolic syndrome?

(2018) Gabriella Garruti et al.   LABORATORY INVESTIGATION

Matrix metalloproteinase functions in hepatic injury and fibrosis

(2018) Martin Roderfeld   MATRIX BIOLOGY

Components of metabolic syndrome increase the risk of mortality in nonalcoholic fatty liver disease (NAFLD)

(2018) Pegah Golabi et al.   MEDICINE

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

(2018) Lesley Hoyles et al.   NATURE MEDICINE

The gut–liver axis and the intersection with the microbiome

(2018) Anupriya Tripathi et al.   Nature Reviews Gastroenterology & Hepatology

Hypoxic Signaling and Cholesterol Lipotoxicity in Fatty Liver Disease Progression

(2018) Oren Tirosh   Oxidative Medicine and Cellular Longevity

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

(2018) Liping Zhao et al.   SCIENCE

Bacterial translocation in patients with liver cirrhosis: physiology, clinical consequences, and practical implications

(2018) Francesca Romana Ponziani et al.   Expert Review of Gastroenterology & Hepatology

Emerging Functions of Regulatory T Cells in Tissue Homeostasis

(2018) Amit Sharma et al.   Frontiers in Immunology

Innate Immune Signaling in Nonalcoholic Fatty Liver Disease and Cardiovascular Diseases

(2018) Jingjing Cai et al.   Annual Review of Pathology-Mechanisms of Disease

Lean non-alcoholic fatty liver disease

(2018) Alice Yuxin Wang et al.   CLINICAL NUTRITION

Liraglutide modulates gut microbiota and reduces NAFLD in obese mice

(2018) GV Moreira et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Gut inflammation exacerbates hepatic injury in the high-fat diet induced NAFLD mouse: Attention to the gut-vascular barrier dysfunction

(2018) Chunwei Cheng et al.   LIFE SCIENCES

Prolonged PM2.5 exposure elevates risk of oxidative stress-driven nonalcoholic fatty liver disease by triggering increase of dyslipidemia

(2018) Min-Xuan Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alcoholic and non-alcoholic fatty liver disease and associations with coronary artery calcification: evidence from the Kangbuk Samsung Health Study

(2018) Yoosoo Chang et al.   GUT

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

Gut microbiota dysbiosis correlates with a low-dose PCB126-induced dyslipidemia and non-alcoholic fatty liver disease

(2018) Yulang Chi et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease

(2017) Charlie C. Park et al.   GASTROENTEROLOGY

Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD

(2017) Na Jiao et al.   GUT

Recovery of ethanol-inducedAkkermansia muciniphiladepletion ameliorates alcoholic liver disease

(2017) Christoph Grander et al.   GUT

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Interplay of innate lymphoid cells and the microbiota

(2017) Liudmila Britanova et al.   IMMUNOLOGICAL REVIEWS

Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3β pathway

(2017) Xiaojuan Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Secondary bile acid-induced dysbiosis promotes intestinal carcinogenesis

(2017) Hailong Cao et al.   INTERNATIONAL JOURNAL OF CANCER

Prophylactic tributyrin treatment mitigates chronic-binge ethanol-induced intestinal barrier and liver injury

(2017) Gail A Cresci et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Microbiome-Modulated Metabolites at the Interface of Host Immunity

(2017) Eran Blacher et al.   JOURNAL OF IMMUNOLOGY

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults

(2017) Leandra Abarca-Gómez et al.   LANCET

Dual function of Lactobacillus kefiri DH5 in preventing high-fat-diet-induced obesity: direct reduction of cholesterol and upregulation of PPAR-α in adipose tissue

(2017) Dong-Hyeon Kim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines

(2017) Joana Dias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of non-steroidal anti-inflammatory drugs on intestinal permeability and nonalcoholic fatty liver disease

(2017) Erika Utzeri et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Dietary Fiber and the Human Gut Microbiota: Application of Evidence Mapping Methodology

(2017) Caleigh Sawicki et al.   Nutrients

Fructose: A Dietary Sugar in Crosstalk with Microbiota Contributing to the Development and Progression of Non-Alcoholic Liver Disease

(2017) Jessica Lambertz et al.   Frontiers in Immunology

Liver and blood cytokine microenvironment in HCV patients is associated to liver fibrosis score: a proinflammatory cytokine ensemble orchestrated by TNF and tuned by IL-10

(2016) Soriane de Souza-Cruz et al.   BMC MICROBIOLOGY

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

(2016) Mahesh S. Desai et al.   CELL

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Hepatocellular Carcinoma in the Absence of Cirrhosis in United States Veterans Is Associated With Nonalcoholic Fatty Liver Disease

(2016) Sahil Mittal et al.   Clinical Gastroenterology and Hepatology

Sex-Specific Effects of Organophosphate Diazinon on the Gut Microbiome and Its Metabolic Functions

(2016) Bei Gao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Sex-Dependent Effects of Cadmium Exposure in Early Life on Gut Microbiota and Fat Accumulation in Mice

(2016) Qian Ba et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

(2016) Khalidur Rahman et al.   GASTROENTEROLOGY

Microbiota-induced obesity requires farnesoid X receptor

(2016) Ava Parséus et al.   GUT

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

(2016) Juan P. Arab et al.   HEPATOLOGY

Changes in blood microbiota profiles associated with liver fibrosis in obese patients: A pilot analysis

(2016) Benjamin Lelouvier et al.   HEPATOLOGY

Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2016) Herbert Tilg et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

Body Mass Index and Risk of Nonalcoholic Fatty Liver Disease: Two Electronic Health Record Prospective Studies

(2016) A. Katrina Loomis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Alcoholic liver disease: focus on prodromal gut health

(2016) Byoungjin Park et al.   Journal of Digestive Diseases

Emerging concepts and future challenges in innate lymphoid cell biology

(2016) Elia D. Tait Wojno et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease

(2016) Jérôme Boursier et al.   JOURNAL OF HEPATOLOGY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways

(2016) Hnin Hnin Aung et al.   JOURNAL OF LIPID RESEARCH

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

(2016) Meric Erikci Ertunc et al.   JOURNAL OF LIPID RESEARCH

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

(2016) Manoela Mota et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The microbiome and innate immunity

(2016) Christoph A. Thaiss et al.   NATURE

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

The role of the gut microbiota in NAFLD

(2016) Christopher Leung et al.   Nature Reviews Gastroenterology & Hepatology

Management of NAFLD: a stage-based approach

(2016) Mary E. Rinella et al.   Nature Reviews Gastroenterology & Hepatology

The intestinal epithelial barrier: a therapeutic target?

(2016) Matthew A. Odenwald et al.   Nature Reviews Gastroenterology & Hepatology

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

A local mechanism by which alcohol consumption causes cancer

(2016) Miguel López-Lázaro   ORAL ONCOLOGY

Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16

(2016) Joakim H. Bergström et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

(2016) G. M. H. Birchenough et al.   SCIENCE

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Trimethylamine N-Oxide: The Good, the Bad and the Unknown

(2016) Manuel Velasquez et al.   Toxins

The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts

(2016) Shuang Liang et al.   Frontiers in Physiology

Acute-on-chronic liver failure in cirrhosis

(2016) Vicente Arroyo et al.   Nature Reviews Disease Primers

Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease

(2016) Marialena Mouzaki et al.   PLoS One

Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults

(2016) Yu-ming Chen et al.   Scientific Reports

Microbiota Protects Mice Against Acute Alcohol-Induced Liver Injury

(2015) Peng Chen et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents

(2015) Helen Luck et al.   Cell Metabolism

Subchronic Exposure of Mice to Cadmium Perturbs Their Hepatic Energy Metabolism and Gut Microbiome

(2015) Songbin Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Gut–liver axis, nutrition, and non-alcoholic fatty liver disease

(2015) Irina A. Kirpich et al.   CLINICAL BIOCHEMISTRY

Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

(2015) Brian C. Ferslew et al.   DIGESTIVE DISEASES AND SCIENCES

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors

(2015) Cheryl A. Brighton et al.   ENDOCRINOLOGY

Mediterranean diet: the missing link between gut microbiota and inflammatory diseases

(2015) M Bifulco   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Supplementation of Saturated Long-Chain Fatty Acids Maintains Intestinal Eubiosis and Reduces Ethanol-induced Liver Injury in Mice

(2015) Peng Chen et al.   GASTROENTEROLOGY

Insulin resistance alters hepatic ethanol metabolism: studies in mice and children with non-alcoholic fatty liver disease

(2015) Anna Janina Engstler et al.   GUT

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

The Role of Oxidative Stress and Antioxidants in Liver Diseases

(2015) Sha Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Small intestinal bacterial overgrowth and toll-like receptor signaling in patients with non-alcoholic fatty liver disease

(2015) Shweta Kapil et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Genetics of liver disease: From pathophysiology to clinical practice

(2015) Tom H. Karlsen et al.   JOURNAL OF HEPATOLOGY

Chlorpyrifos Exposure During Perinatal Period Impacts Intestinal Microbiota Associated with Delay of Maturation of Digestive Tract in Rats

(2015) Claire Joly Condette et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Leaky guts: intestinal permeability and NASH

(2015) Katrina Ray   Nature Reviews Gastroenterology & Hepatology

Alcohol Induced Alterations to the Human Fecal VOC Metabolome

(2015) Robin D. Couch et al.   PLoS One

A gut-vascular barrier controls the systemic dissemination of bacteria

(2015) Ilaria Spadoni et al.   SCIENCE

TGR5 and Immunometabolism: Insights from Physiology and Pharmacology

(2015) Alessia Perino et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Gut microbiota and liver diseases

(2015) Masami Minemura   WORLD JOURNAL OF GASTROENTEROLOGY

Role of the normal gut microbiota

(2015) Sai Manasa Jandhyala   WORLD JOURNAL OF GASTROENTEROLOGY

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis

(2015) Petra Krause et al.   Nature Communications

Diagnosis and treatment of small intestinal bacterial overgrowth

(2015) Francesca Romana Ponziani et al.   Expert Review of Gastroenterology & Hepatology

Molecular Mechanisms of NAFLD in Metabolic Syndrome

(2015) Maria João Martins et al.   Biomed Research International

SIgA Binding to Mucosal Surfaces Is Mediated by Mucin-Mucin Interactions

(2015) Hannah L. Gibbins et al.   PLoS One

Tributyrin Supplementation Protects Mice from Acute Ethanol-Induced Gut Injury

(2014) Gail A. Cresci et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Randomised clinical trial: the beneficial effects of VSL#3 in obese children with non-alcoholic steatohepatitis

(2014) A. Alisi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Intestinal permeability – a new target for disease prevention and therapy

(2014) Stephan C Bischoff et al.   BMC GASTROENTEROLOGY

Unique aspects of fiber degradation by the ruminal ethanologen Ruminococcus albus 7 revealed by physiological and transcriptomic analysis

(2014) Melissa R Christopherson et al.   BMC GENOMICS

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Intestinal permeability is increased in children with non-alcoholic fatty liver disease, and correlates with liver disease severity

(2014) Valentina Giorgio et al.   DIGESTIVE AND LIVER DISEASE

The composition of the gut microbiota shapes the colon mucus barrier

(2014) H. E. Jakobsson et al.   EMBO REPORTS

Oxysterols induce mitochondrial impairment and hepatocellular toxicity in non-alcoholic fatty liver disease

(2014) Francesco Bellanti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interactions Between the Intestinal Microbiome and Liver Diseases

(2014) Bernd Schnabl et al.   GASTROENTEROLOGY

High-fat diet alters the oligosaccharide chains of colon mucins in mice

(2014) Maria Mastrodonato et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Oral Tolerance Can Be Established via Gap Junction Transfer of Fed Antigens from CX3CR1+ Macrophages to CD103+ Dendritic Cells

(2014) Elisa Mazzini et al.   IMMUNITY

Epithelial Microvilli Establish an Electrostatic Barrier to Microbial Adhesion

(2014) Kaila M. Bennett et al.   INFECTION AND IMMUNITY

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of interleukin 10 in norfloxacin prevention of luminal free endotoxin translocation in mice with cirrhosis

(2014) Isabel Gómez-Hurtado et al.   JOURNAL OF HEPATOLOGY

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

(2014) Alexandra J. Corbett et al.   NATURE

You are what you eat

(2014) Harald Brüssow et al.   NATURE BIOTECHNOLOGY

The liver as a firewall—clearance of commensal bacteria that have escaped from the gut

(2014) Natalie J. Wood   Nature Reviews Gastroenterology & Hepatology

Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity

(2014) Sophie Leclercq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota

(2014) M. L. Balmer et al.   Science Translational Medicine

Architecture of tight junctions and principles of molecular composition

(2014) Christina M. Van Itallie et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Oxidative stress as a crucial factor in liver diseases

(2014) Halina Cichoż-Lach   WORLD JOURNAL OF GASTROENTEROLOGY

Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates

(2013) Kylie Kavanagh et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Glycobiome: Bacteria and mucus at the epithelial interface

(2013) Janneke P. Ouwerkerk et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent

(2013) Laura Wrzosek et al.   BMC BIOLOGY

Pleiotropic Roles of Bile Acids in Metabolism

(2013) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Humans With Nonalcoholic Fatty Liver Disease

(2013) Maitreyi Raman et al.   Clinical Gastroenterology and Hepatology

Cholineʼs role in maintaining liver function

(2013) Mihai G. Mehedint et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Gut-liver Axis and Microbiota in NAFLD: Insight Pathophysiology for Novel Therapeutic Target

(2013) Luca Miele et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting lipid sensing in the central nervous system: new therapy against the development of obesity and type 2 diabetes

(2013) Hervé Le Stunff et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

(2013) Jennifer E. Lambert et al.   GASTROENTEROLOGY

Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice

(2013) Phillipp Hartmann et al.   HEPATOLOGY

Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance

(2013) Xin-An Wang et al.   HEPATOLOGY

Cadmium Exposure and Liver Disease among US Adults

(2013) Omar Hyder et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Pathological bacterial translocation in liver cirrhosis

(2013) Reiner Wiest et al.   JOURNAL OF HEPATOLOGY

Chronic Ethanol Consumption Alters Mammalian Gastrointestinal Content Metabolites

(2013) Guoxiang Xie et al.   JOURNAL OF PROTEOME RESEARCH

Early Diet Impacts Infant Rhesus Gut Microbiome, Immunity, and Metabolism

(2013) Aifric O’Sullivan et al.   JOURNAL OF PROTEOME RESEARCH

Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor  

(2013) S. Alex et al.   MOLECULAR AND CELLULAR BIOLOGY

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function

(2013) Ana C. Monteiro et al.   MOLECULAR BIOLOGY OF THE CELL

Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses

(2013) Keiji Hirota et al.   NATURE IMMUNOLOGY

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

Blood Microbiota Dysbiosis Is Associated with the Onset of Cardiovascular Events in a Large General Population: The D.E.S.I.R. Study

(2013) Jacques Amar et al.   PLoS One

Smoking Cessation Induces Profound Changes in the Composition of the Intestinal Microbiota in Humans

(2013) Luc Biedermann et al.   PLoS One

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PNPLA3-Associated Steatohepatitis: Toward a Gene-Based Classification of Fatty Liver Disease

(2013) Marcin Krawczyk et al.   SEMINARS IN LIVER DISEASE

A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes

(2013) Ignazio Grattagliano   WORLD JOURNAL OF GASTROENTEROLOGY

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

In situ characterization of O-linked glycans of Muc2 in mouse colon

(2012) Giuseppa Esterina Liquori et al.   ACTA HISTOCHEMICA

Colonic microbiome is altered in alcoholism

(2012) Ece A. Mutlu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling

(2012) Kento Imajo et al.   Cell Metabolism

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

Impact of chronic exposure to low doses of chlorpyrifos on the intestinal microbiota in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) and in the rat

(2012) Claire Joly et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Toll-Like Receptor 2–Mediated Intestinal Injury and Enteric Tumor Necrosis Factor Receptor I Contribute to Liver Fibrosis in Mice

(2012) Phillipp Hartmann et al.   GASTROENTEROLOGY

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model

(2012) Katerina Tsilingiri et al.   GUT

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target

(2012) Hua Wang et al.   International Journal of Biological Sciences

Prevalence and risk factors for non-alcoholic fatty liver disease in Asian people who are not obese

(2012) Chun-Jen Liu   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Phenotyping the effect of diet on non-alcoholic fatty liver disease

(2012) Nicole J.W. de Wit et al.   JOURNAL OF HEPATOLOGY

Nonalcoholic Fatty Liver Disease in Lean Individuals in the United States

(2012) Zobair M. Younossi et al.   MEDICINE

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Reciprocal interactions of the intestinal microbiota and immune system

(2012) Craig L. Maynard et al.   NATURE

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Effects of Ethanol and Acetaldehyde on Tight Junction Integrity: In Vitro Study in a Three Dimensional Intestinal Epithelial Cell Culture Model

(2012) Elhaseen Elamin et al.   PLoS One

Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins

(2012) Malin E. V. Johansson   PLoS One

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Role of ceramides in nonalcoholic fatty liver disease

(2012) Mangesh Pagadala et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

ERK is involved in EGF-mediated protection of tight junctions, but not adherens junctions, in acetaldehyde-treated Caco-2 cell monolayers

(2011) G. Samak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept

(2011) J. Amar et al.   DIABETOLOGIA

The Bile Acid Membrane Receptor TGR5: A Valuable Metabolic Target

(2011) Thijs W.H. Pols et al.   DIGESTIVE DISEASES

Altered distribution of caveolin-1 in early liver steatosis

(2011) Maria Mastrodonato et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Altered intestinal tight junctions’ expression in patients with liver cirrhosis: a pathogenetic mechanism of intestinal hyperpermeability

(2011) Stelios F. Assimakopoulos et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota

(2011) Matteo Serino et al.   GUT

Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease

(2011) V. W.-S. Wong et al.   GUT

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice

(2011) Savitha Subramanian et al.   JOURNAL OF LIPID RESEARCH

Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut

(2011) Ekihiro Seki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis

(2011) Gianluca Svegliati-Baroni et al.   LIVER INTERNATIONAL

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

   intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface

(2011) A. S. Ismail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enterocyte death and intestinal barrier maintenance in homeostasis and disease

(2011) Lars Vereecke et al.   TRENDS IN MOLECULAR MEDICINE

Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila

(2011) Muriel Derrien et al.   Frontiers in Microbiology

Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications

(2010) Jongsook Kim Kemper   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Obesity, Diabetes, and Gut Microbiota: The hygiene hypothesis expanded?

(2010) G. Musso et al.   DIABETES CARE

Polychlorinated Biphenyls, Lead, and Mercury Are Associated with Liver Disease in American Adults: NHANES 2003–2004

(2010) Matt Cave et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

(2010) Kouichi Miura et al.   GASTROENTEROLOGY

Association Between Composition of the Human Gastrointestinal Microbiome and Development of Fatty Liver With Choline Deficiency

(2010) Melanie D. Spencer et al.   GASTROENTEROLOGY

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

(2010) Christopher D. Williams et al.   GASTROENTEROLOGY

Bacterial DNA translocation is associated with systemic circulatory abnormalities and intrahepatic endothelial dysfunction in patients with cirrhosis

(2010) Pablo Bellot et al.   HEPATOLOGY

Enteric dysbiosis associated with a mouse model of alcoholic liver disease

(2010) Arthur W. Yan et al.   HEPATOLOGY

Dietary Choline Deprivation Impairs Rat Brain Mitochondrial Function and Behavioral Phenotype

(2010) Consiglia Pacelli et al.   JOURNAL OF NUTRITION

Multiple facets of intestinal permeability and epithelial handling of dietary antigens

(2010) S Ménard et al.   Mucosal Immunology

An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells

(2010) Woo-Yong Lee et al.   NATURE IMMUNOLOGY

Acetaldehyde Adducts in Alcoholic Liver Disease

(2010) Mashiko Setshedi et al.   Oxidative Medicine and Cellular Longevity

Role of Alcohol Metabolism in Non-Alcoholic Steatohepatitis

(2010) Susan S. Baker et al.   PLoS One

High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse

(2010) Shengli Ding et al.   PLoS One

Methodology and Indications of H2-Breath Testing in Gastrointestinal Diseases: the Rome Consensus Conference

(2009)   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Intestinal microflora and metabolic diseases

(2009) M. Serino et al.   DIABETES & METABOLISM

Intestinal permeability in patients with chronic liver diseases: Its relationship with the aetiology and the entity of liver damage

(2009) Rita Cariello et al.   DIGESTIVE AND LIVER DISEASE

The role of pH in determining the species composition of the human colonic microbiota

(2009) Sylvia H. Duncan et al.   ENVIRONMENTAL MICROBIOLOGY

Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio

(2009) Salvatore Modica   Frontiers in Bioscience-Landmark

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice

(2009) Astrid Spruss et al.   HEPATOLOGY

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

New molecular insights into the mechanisms of cholestasis

(2009) Martin Wagner et al.   JOURNAL OF HEPATOLOGY

Lipopolysaccharide triggered TNF-α-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model

(2009) Hiroshi Kudo et al.   JOURNAL OF HEPATOLOGY

Bile acid transporters

(2009) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Choline: an essential nutrient for public health

(2009) Steven H Zeisel et al.   NUTRITION REVIEWS

Serum levels of hyaluronic acid and tissue metalloproteinase inhibitor-1 combined with age predict the presence of nonalcoholic steatohepatitis in a pilot cohort of subjects with nonalcoholic fatty liver disease

(2009) Luca Miele et al.   Translational Research

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Role of TLR9 in hepatic stellate cells and experimental liver fibrosis

(2008) Erwin Gäbele et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Optimized Proteomic Analysis on Gels of Cell−Cell Adhering Junctional Membrane Proteins†

(2008) Yuji Yamazaki et al.   BIOCHEMISTRY

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Severe liver steatosis correlates with nitrosative and oxidative stress in rats

(2008) I. Grattagliano et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Unique Role of Junctional Adhesion Molecule-A in Maintaining Mucosal Homeostasis in Inflammatory Bowel Disease

(2008) Stefania Vetrano et al.   GASTROENTEROLOGY

Secreted enteric antimicrobial activity localises to the mucus surface layer

(2008) U Meyer-Hoffert et al.   GUT

Coordinate regulation of gallbladder motor function in the gut-liver axis

(2008) Piero Portincasa et al.   HEPATOLOGY

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2

(2008) C. M. Van Itallie et al.   JOURNAL OF CELL SCIENCE

Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats

(2008) Ali Keshavarzian et al.   JOURNAL OF HEPATOLOGY

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA