The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts

Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice

(2015) Ahmed Bettaieb et al.   GASTROENTEROLOGY

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Pyrroloquinoline-Quinone Suppresses Liver Fibrogenesis in Mice

(2015) Dongwei Jia et al.   PLoS One

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

(2015) Tian Lan et al.   PLoS One

Oxidative Stress Mediated Mitochondrial and Vascular Lesions as Markers in the Pathogenesis of Alzheimer Disease

(2014) G. Aliev et al.   CURRENT MEDICINAL CHEMISTRY

Superoxide anion radicals activate hepatic stellate cells after entry through chloride channels: A new target in liver fibrosis

(2014) Gertjan J.M. den Hartog et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliary cirrhosis

(2014) Gaetano Serviddio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Liver cirrhosis

(2014) Emmanuel A Tsochatzis et al.   LANCET

Role of NADPH Oxidases in Liver Fibrosis

(2013) Yong-Han Paik et al.   ANTIOXIDANTS & REDOX SIGNALING

Roles of DUOX-Mediated Hydrogen Peroxide in Metabolism, Host Defense, and Signaling

(2013) Xavier De Deken et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione metabolism and Parkinson's disease

(2013) Michelle Smeyne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evolving therapies for liver fibrosis

(2013) Detlef Schuppan et al.   JOURNAL OF CLINICAL INVESTIGATION

Xanthine Oxido-Reductase, Free Radicals and Cardiovascular Disease. A Critical Review

(2013) A. M. Robert et al.   PATHOLOGY & ONCOLOGY RESEARCH

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Reactive Oxygen Species and Antioxidants in Pulmonary Hypertension

(2012) Chi-Ming Wong et al.   ANTIOXIDANTS & REDOX SIGNALING

Nox4 modulates collagen production stimulated by transforming growth factor β1 in vivo and in vitro

(2012) Elsa C. Chan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Oxidative Stress and Molecular Changes in Liver Fibrosis: A Review

(2012) V. Sanchez-Valle et al.   CURRENT MEDICINAL CHEMISTRY

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

(2012) Joy X. Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells

(2012) Howard E. Boudreau et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

(2012) Tomonori Aoyama et al.   HEPATOLOGY

NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development

(2012) Patricia Sancho et al.   PLoS One

Toll-Like Receptors in Liver Fibrosis: Cellular Crosstalk and Mechanisms

(2012) Ling Yang et al.   Frontiers in Physiology

The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

(2011) Yong-Han Paik et al.   HEPATOLOGY

NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation

(2011) Wenhao Cui et al.   HEPATOLOGY

Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts

(2011) Hartmut Jaeschke   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

ROS Signaling by NOX4 Drives Fibroblast-to-Myofibroblast Differentiation in the Diseased Prostatic Stroma

(2011) Natalie Sampson et al.   MOLECULAR ENDOCRINOLOGY

Regulation of reactive oxygen species generation in cell signaling

(2011) Yun Soo Bae et al.   MOLECULES AND CELLS

Genetic Labeling Does Not Detect Epithelial-to-Mesenchymal Transition of Cholangiocytes in Liver Fibrosis in Mice

(2010) David Scholten et al.   GASTROENTEROLOGY

Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 Plays a Key Role in Stellate Cell Activation and Liver Fibrogenesis In Vivo

(2010) Joy X. Jiang et al.   GASTROENTEROLOGY

Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis

(2010) Samuele De Minicis et al.   HEPATOLOGY

The Fibroblast Integrin α11β1 Is Induced in a Mechanosensitive Manner Involving Activin A and Regulates Myofibroblast Differentiation

(2010) Sergio Carracedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Investigating the Role of P311 in the Hypertrophic Scar

(2010) Jianglin Tan et al.   PLoS One

Toll-Like Receptor Signaling and Liver Fibrosis

(2010) Tomonori Aoyama et al.   Gastroenterology Research and Practice

Emerging Concepts in the Pathogenesis of Lung Fibrosis

(2009) William D. Hardie et al.   AMERICAN JOURNAL OF PATHOLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Overactivation of the MEK/ERK Pathway in Liver Tumor Cells Confers Resistance to TGF- -Induced Cell Death through Impairing Up-regulation of the NADPH Oxidase NOX4

(2009) L. Caja et al.   CANCER RESEARCH

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

Negligible Contribution of Bone Marrow-Derived Cells to Collagen Production During Hepatic Fibrogenesis in Mice

(2009) Reiichi Higashiyama et al.   GASTROENTEROLOGY

Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice

(2009) Kojiro Taura et al.   HEPATOLOGY

The myofibroblast: Paradigm for a mechanically active cell

(2009) Boris Hinz   JOURNAL OF BIOMECHANICS

Toll-like receptor activated human and murine hepatic stellate cells are potent regulators of hepatitis C virus replication

(2009) Bo Wang et al.   JOURNAL OF HEPATOLOGY

NAD(P)H Oxidase Mediates TGF- 1-Induced Activation of Kidney Myofibroblasts

(2009) C. D. Bondi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Endosialin (Tem1) Is a Marker of Tumor-Associated Myofibroblasts and Tumor Vessel-Associated Mural Cells

(2008) Sven Christian et al.   AMERICAN JOURNAL OF PATHOLOGY

The AP-1 site is essential for the promoter activity of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme: Possible involvement of the ERK1/2-JunB pathway

(2008) Muhammer Ozgur Cevik et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration

(2008) Ghazaleh Aram et al.   HEPATOLOGY

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

(2008) Irene Carmona-Cuenca et al.   JOURNAL OF HEPATOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS