The Role of Specialized Pro-Resolving Mediators in Cystic Fibrosis Airways Disease

Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

(2020) Heledd H Jarosz-Griffiths et al.   eLife

CFTR Modulators: The Changing Face of Cystic Fibrosis in the Era of Precision Medicine

(2020) Miquéias Lopes-Pacheco   Frontiers in Pharmacology

Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis

(2020) Adam J. Causer et al.   Redox Biology

Resolvin D1 Reduces Lung Infection and Inflammation Activating Resolution in Cystic Fibrosis

(2020) Elisa Isopi et al.   Frontiers in Immunology

Abnormal n-6 fatty acid metabolism in cystic fibrosis contributes to pulmonary symptoms

(2020) Craig E. Wheelock et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Resolvin D2 elevates cAMP to increase intracellular [Ca2+] and stimulate secretion from conjunctival goblet cells

(2019) Nora Botten et al.   FASEB JOURNAL

Gene modifiers of cystic fibrosis lung disease: A systematic review

(2019) Shivanthan Shanthikumar et al.   PEDIATRIC PULMONOLOGY

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

(2019) Charles R. Esther et al.   Science Translational Medicine

Disease progression in patients with cystic fibrosis treated with ivacaftor: Data from national US and UK registries

(2019) Nataliya Volkova et al.   Journal of Cystic Fibrosis

Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis

(2019) Juliette Simonin et al.   Scientific Reports

Arachidonic Acid and Docosahexaenoic Acid Metabolites in the Airways of Adults With Cystic Fibrosis: Effect of Docosahexaenoic Acid Supplementation

(2019) Elisabetta Teopompi et al.   Frontiers in Pharmacology

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation

(2019) Samuel Lara-Reyna et al.   Frontiers in Immunology

Safety, Tolerability, and Effects of Sodium Bicarbonate Inhalation in Cystic Fibrosis

(2019) Carla Cristina Souza Gomez et al.   CLINICAL DRUG INVESTIGATION

Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions

(2019) Nan Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL‐1 signaling pathway

(2019) Anita Balázs et al.   PEDIATRIC PULMONOLOGY

Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction

(2019) Nicholas M. Maurice et al.   Scientific Reports

The MUC5B mucin polymer is dominated by repeating structural motifs and its topology is regulated by calcium and pH

(2019) Gareth W. Hughes et al.   Scientific Reports

Resolution metabolomes activated by hypoxic environment

(2019) Paul C. Norris et al.   Science Advances

An Intriguing Involvement of Mitochondria in Cystic Fibrosis

(2019) Favia et al.   Journal of Clinical Medicine

Vx-809/Vx-770 treatment reduces inflammatory response to Pseudomonas aeruginosa in primary differentiated cystic fibrosis bronchial epithelial cells

(2018) Manon Ruffin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lumacaftor (VX-809) restores the ability of CF macrophages to phagocytose and kill Pseudomonas aeruginosa

(2018) Roxanna Barnaby et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Infection Is Not Required for Mucoinflammatory Lung Disease in CFTR-Knockout Ferrets

(2018) Bradley H. Rosen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Potent Anti-Inflammatory and Pro-Resolving Effects of Anabasum in a Human Model of Self-Resolving Acute Inflammation

(2018) Madhur P. Motwani et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Calcium signalling and related ion channels in neutrophil recruitment and function

(2018) Roland Immler et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca 2+ in cultured rat conjunctival goblet cells

(2018) Marit Lippestad et al.   EXPERIMENTAL EYE RESEARCH

AT-RVD1 repairs mouse lung after cigarette smoke-induced emphysema via downregulation of oxidative stress by NRF2/KEAP1 pathway

(2018) Sara Vergel Posso et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

(2018) Sangsu Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

CFTR rescue with VX-809 and VX-770 favors the repair of primary airway epithelial cell cultures from patients with class II mutations in the presence of Pseudomonas aeruginosa exoproducts

(2018) Damien Adam et al.   Journal of Cystic Fibrosis

Recent Progress in CFTR Interactome Mapping and Its Importance for Cystic Fibrosis

(2018) Sang Hyun Lim et al.   Frontiers in Pharmacology

EMPIRE-CF: A phase II randomized placebo-controlled trial of once-daily, oral acebilustat in adult patients with cystic fibrosis – Study design and patient demographics

(2018) J. Stuart Elborn et al.   Contemporary Clinical Trials

Specialized Pro-Resolving Lipid Mediators in Cystic Fibrosis

(2018) Réginald Philippe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

(2018) Georg Schett et al.   Nature Communications

Resolution of sickle cell disease–associated inflammation and tissue damage with 17R-resolvin D1

(2018) Alessandro Matte et al.   BLOOD

Pathological Mucus and Impaired Mucus Clearance in Cystic Fibrosis Patients Results from Increased Concentration, not altered pH

(2018) David B. Hill et al.   EUROPEAN RESPIRATORY JOURNAL

Aspirin-triggered resolvin D1 alleviates paraquat-induced acute lung injury in mice

(2018) Xiao Hu et al.   LIFE SCIENCES

Lipoxin A4 stimulates endothelial miR-126-5p expression and its transfer via microvesicles

(2017) Marilina Codagnone et al.   FASEB JOURNAL

Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution

(2017) Jesmond Dalli et al.   IMMUNITY

Immunomodulatory Effects of Antimicrobial Drugs

(2017) Christine Ruh et al.   IMMUNOLOGICAL INVESTIGATIONS

Resolvin D1 regulates epithelial ion transport and inflammation in cystic fibrosis airways

(2017) Fiona C. Ringholz et al.   Journal of Cystic Fibrosis

CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis

(2017) Abdullah A. Tarique et al.   Journal of Cystic Fibrosis

ResolvinD1 stimulates epithelial wound repair and inhibits TGF-β-induced EMT whilst reducing fibroproliferation and collagen production

(2017) Shengxing Zheng et al.   LABORATORY INVESTIGATION

Maresin1 stimulates alveolar fluid clearance through the alveolar epithelial sodium channel Na,K-ATPase via the ALX/PI3K/Nedd4-2 pathway

(2017) Jun-Li Zhang et al.   LABORATORY INVESTIGATION

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

(2017) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection

(2017) M Codagnone et al.   Mucosal Immunology

Gel-forming mucins form distinct morphologic structures in airways

(2017) Lynda S. Ostedgaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics

(2017) Justin T. English et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Airway surface liquid pH is not acidic in children with cystic fibrosis

(2017) André Schultz et al.   Nature Communications

Pro-resolving lipid mediator Resolvin D1 serves as a marker of lung disease in cystic fibrosis

(2017) Olaf Eickmeier et al.   PLoS One

microRNA-181b is increased in cystic fibrosis cells and impairs lipoxin A4 receptor-dependent mechanisms of inflammation resolution and antimicrobial defense

(2017) Anna Maria Pierdomenico et al.   Scientific Reports

Lipoxin A4 prevents tight junction disruption and delays the colonization of cystic fibrosis bronchial epithelial cells by Pseudomonas aeruginosa

(2016) Gerard Higgins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus

(2016) Jennifer A. Bartlett et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Architecture and functional properties of the CFTR channel pore

(2016) Paul Linsdell   CELLULAR AND MOLECULAR LIFE SCIENCES

Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis

(2016) JS Elborn et al.   CTS-Clinical and Translational Science

n-3 Fatty acid supplementation and proresolving mediators of inflammation

(2016) Anne E. Barden et al.   CURRENT OPINION IN LIPIDOLOGY

Hypoxia and sterile inflammation in cystic fibrosis airways: mechanisms and potential therapies

(2016) Samuel T. Montgomery et al.   EUROPEAN RESPIRATORY JOURNAL

Chronic systemic inflammation originating from epithelial tissues

(2016) Özge Uluçkan et al.   FEBS Journal

Lipoxin A4 attenuates LPS-induced mouse acute lung injury via Nrf2-mediated E-cadherin expression in airway epithelial cells

(2016) Xue Cheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epithelial sodium channel (ENaC) family: Phylogeny, structure–function, tissue distribution, and associated inherited diseases

(2016) Israel Hanukoglu et al.   GENE

Characterization of mitochondrial function in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function

(2016) Anna Atlante et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device

(2016) Kevin D. Lance et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Novel Resolvin D2 Receptor Axis in Infectious Inflammation

(2016) Nan Chiang et al.   JOURNAL OF IMMUNOLOGY

Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation

(2016) Romain A. Colas et al.   JOURNAL OF IMMUNOLOGY

Cystic Fibrosis Lung Immunity: The Role of the Macrophage

(2016) Emanuela M. Bruscia et al.   Journal of Innate Immunity

Lipoxin A4 activates ALX/FPR2 receptor to regulate conjunctival goblet cell secretion

(2016) R R Hodges et al.   Mucosal Immunology

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

(2016) Jesmond Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses

(2016) Valerio Chiurchiù et al.   Science Translational Medicine

The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation

(2016) Aleksander M. Grabiec et al.   Seminars in Immunopathology

Goblet Cell Hyperplasia Requires High Bicarbonate Transport To Support Mucin Release

(2016) Giulia Gorrieri et al.   Scientific Reports

Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion

(2016) James Peter Garnett et al.   Scientific Reports

Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent

(2015) Sarah K. Orr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Resolvins Attenuate Inflammation and Promote Resolution in Cigarette Smoke-Exposed Human Macrophages

(2015) Amanda Croasdell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Defective Innate Immunity and Hyperinflammation in Newborn Cystic Fibrosis Transmembrane Conductance Regulator–Knockout Ferret Lungs

(2015) Nicholas W. Keiser et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide

(2015) Jesmond Dalli et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS

(2015) Ai Sasaki et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells

(2015) Réginald Philippe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

Dynamically Regulated CFTR Expression and Its Functional Role in Cutaneous Wound Healing

(2015) Jianda Dong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA Dysregulation in Cystic Fibrosis

(2015) Paul J. McKiernan et al.   MEDIATORS OF INFLAMMATION

Gaseous mediators in resolution of inflammation

(2015) John L. Wallace et al.   SEMINARS IN IMMUNOLOGY

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

(2015) Harriet Corvol et al.   Nature Communications

Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells

(2015) Bruce A. Stanton et al.   PLoS One

Resolvins Decrease Oxidative Stress Mediated Macrophage and Epithelial Cell Interaction through Decreased Cytokine Secretion

(2015) Ruan Cox et al.   PLoS One

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

(2014) Romain A. Colas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of anion exchangers in Cl− and HCO3− secretion by the human airway epithelial cell line Calu-3

(2014) Dusik Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased β1-integrin signaling and delayed wound repair

(2014) Yutaka Itokazu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Activation of P2RY11 and ATP Release by LXA4Restores the Airway Surface Liquid Layer and Epithelial Repair in Cystic Fibrosis

(2014) Gerard Higgins et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study

(2014) Fernando Augusto de Fernando August Marson et al.   BMC Medical Genetics

Oxidation contributes to low glutathione in the airways of children with cystic fibrosis

(2014) A. J. Kettle et al.   EUROPEAN RESPIRATORY JOURNAL

Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis

(2014) F. C. Ringholz et al.   EUROPEAN RESPIRATORY JOURNAL

Transcription factors and miRNAs that regulate fetal to adult CFTR expression change are new targets for cystic fibrosis

(2014) V. Viart et al.   EUROPEAN RESPIRATORY JOURNAL

Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution-phase mouse macrophages

(2014) Antonio Recchiuti et al.   FASEB JOURNAL

MicroRNA-181b Regulates ALX/FPR2 Receptor Expression and Proresolution Signaling in Human Macrophages

(2014) Anna Maria Pierdomenico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure

(2014) Ashley G. Henderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Proresolving Nanomedicines Activate Bone Regeneration in Periodontitis

(2014) T.E. Van Dyke et al.   JOURNAL OF DENTAL RESEARCH

Vagus nerve controls resolution and pro-resolving mediators of inflammation

(2014) Valbona Mirakaj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resolvin D1 Attenuates Polyinosinic-Polycytidylic Acid–Induced Inflammatory Signaling in Human Airway Epithelial Cells via TAK1

(2014) Hsi-Min Hsiao et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Maresin-1 Engages Regulatory T Cells To Limit Type 2 Innate Lymphoid Cell Activation and Promote Resolution of Lung Inflammation

(2014) Nandini Krishnamoorthy et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 Stimulates Alveolar Fluid Clearance through Alveolar Epithelial Sodium Channel, Na,K-ATPase via ALX/cAMP/PI3K Pathway in Lipopolysaccharide-Induced Acute Lung Injury

(2014) Q. Wang et al.   JOURNAL OF IMMUNOLOGY

Lipoxin B4 promotes the resolution of allergic inflammation in the upper and lower airways of mice

(2014) L Karra et al.   Mucosal Immunology

Transcellular biosynthesis of eicosanoids

(2014) Angelo Sala et al.   Pharmacological Reports

Characterization of Defects in Ion Transport and Tissue Development in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Knockout Rats

(2014) Katherine L. Tuggle et al.   PLoS One

Proteomic Analysis of Nasal Epithelial Cells from Cystic Fibrosis Patients

(2014) Ludovic Jeanson et al.   PLoS One

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4synthesis by inhibiting a calcium-activated kinase pathway

(2014) Gabrielle Fredman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

(2014) J. Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis

(2014) M. J. Hoegger et al.   SCIENCE

Lipoxin A4-mediated KATP potassium channel activation results in cystic fibrosis airway epithelial repair

(2013) Paul J. Buchanan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Bioelectric Characterization of Epithelia from NeonatalCFTRKnockout Ferrets

(2013) John T. Fisher et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lung Phenotype of Juvenile and Adult Cystic Fibrosis Transmembrane Conductance Regulator–Knockout Ferrets

(2013) Xingshen Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis

(2013) Ha-Na Lee et al.   BIOCHEMICAL PHARMACOLOGY

Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis

(2013) Manon Ruffin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Genetic interaction of GSH metabolic pathway genes in cystic fibrosis

(2013) Fernando Augusto de Lima Marson et al.   BMC Medical Genetics

The CF-modifying gene EHF promotes p.Phe508del-CFTR residual function by altering protein glycosylation and trafficking in epithelial cells

(2013) Frauke Stanke et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Resolvin D1 stimulates efferocytosis through p50/p50-mediated suppression of tumor necrosis factor-  expression

(2013) H.-N. Lee et al.   JOURNAL OF CELL SCIENCE

Proresolving and Tissue-Protective Actions of Annexin A1-Based Cleavage-Resistant Peptides Are Mediated by Formyl Peptide Receptor 2/Lipoxin A4 Receptor

(2013) J. Dalli et al.   JOURNAL OF IMMUNOLOGY

Inhaled Carbon Monoxide Accelerates Resolution of Inflammation via Unique Proresolving Mediator-Heme Oxygenase-1 Circuits

(2013) N. Chiang et al.   JOURNAL OF IMMUNOLOGY

Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGF R1

(2013) E. P. Brennan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation

(2013) Gisela Adrienne Weiss et al.   Lipids in Health and Disease

Contribution of CFTR to Alveolar Fluid Clearance by Lipoxin A4via PI3K/Akt Pathway in LPS-Induced Acute Lung Injury

(2013) Yi Yang et al.   MEDIATORS OF INFLAMMATION

Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion

(2013) D Li et al.   Mucosal Immunology

Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma

(2013) C. Barnig et al.   Science Translational Medicine

Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formation

(2012) Olutayo Odusanwo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The CFTR and ENaC debate: how important is ENaC in CF lung disease?

(2012) James F. Collawn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Resolvins D1, D2, and Other Mediators of Self-Limited Resolution of Inflammation in Human Blood following n-3 Fatty Acid Supplementation

(2012) E. Mas et al.   CLINICAL CHEMISTRY

Improvement of defective cystic fibrosis airway epithelial wound repair after CFTR rescue

(2012) Nguyen Thu Ngan Trinh et al.   EUROPEAN RESPIRATORY JOURNAL

Lipoxin A4 inhibits platelet-activating factor inflammatory response and stimulates corneal wound healing of injuries that compromise the stroma

(2012) Azucena Kakazu et al.   EXPERIMENTAL EYE RESEARCH

Leukocyte recruitment in the brain in sepsis: involvement of the annexin 1-FPR2/ALX anti-inflammatory system

(2012) Felicity N. E. Gavins et al.   FASEB JOURNAL

Annexin A1 Interaction with the FPR2/ALX Receptor

(2012) Stefania Bena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid

(2012) Yosuke Isobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atypical Activation of the Unfolded Protein Response in Cystic Fibrosis Airway Cells Contributes to p38 MAPK-Mediated Innate Immune Responses

(2012) C. J. Blohmke et al.   JOURNAL OF IMMUNOLOGY

Resolvin E2 Formation and Impact in Inflammation Resolution

(2012) S. F. Oh et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 and Aspirin-Triggered Resolvin D1 Promote Resolution of Allergic Airways Responses

(2012) A. P. Rogerio et al.   JOURNAL OF IMMUNOLOGY

Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury

(2012) O Eickmeier et al.   Mucosal Immunology

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

(2012) Alejandro A. Pezzulo et al.   NATURE

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Lipoxin A4 Stimulates Calcium-Activated Chloride Currents and Increases Airway Surface Liquid Height in Normal and Cystic Fibrosis Airway Epithelia

(2012) Valia Verrière et al.   PLoS One

The Mitochondrial Complex I Activity Is Reduced in Cells with Impaired Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function

(2012) Angel G. Valdivieso et al.   PLoS One

Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway

(2012) Zenglin Liao et al.   RESPIRATORY RESEARCH

A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia

(2012) B. Button et al.   SCIENCE

Self-Limited versus Delayed Resolution of Acute Inflammation: Temporal Regulation of Pro-Resolving Mediators and MicroRNA

(2012) Gabrielle Fredman et al.   Scientific Reports

Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress

(2012) Rina Takamiya et al.   FEBS Open Bio

Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung

(2011) Ahmed Lazrak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Infection, Inflammation, and Lung Function Decline in Infants with Cystic Fibrosis

(2011) Naveen Pillarisetti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice

(2011) Jason Hellmann et al.   FASEB JOURNAL

Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching

(2011) Nico Derichs et al.   FASEB JOURNAL

Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways

(2011) Haouaria Balghi et al.   FASEB JOURNAL

Adenosine promotes alternative macrophage activation via A2A and A2B receptors

(2011) Balázs Csóka et al.   FASEB JOURNAL

GSH monoethyl ester rescues mitochondrial defects in cystic fibrosis models

(2011) M. Kelly-Aubert et al.   HUMAN MOLECULAR GENETICS

Prostaglandin-endoperoxide synthase genesCOX1 andCOX2 — novel modifiers of disease severity in cystic fibrosis patients

(2011) K. Czerska et al.   JOURNAL OF APPLIED GENETICS

Novel Role for Pendrin in Orchestrating Bicarbonate Secretion in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-expressing Airway Serous Cells

(2011) James P. Garnett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abnormal Trafficking and Degradation of TLR4 Underlie the Elevated Inflammatory Response in Cystic Fibrosis

(2011) E. M. Bruscia et al.   JOURNAL OF IMMUNOLOGY

Conjunctival Goblet Cell Secretion Stimulated by Leukotrienes Is Reduced by Resolvins D1 and E1 To Promote Resolution of Inflammation

(2011) Darlene A. Dartt et al.   JOURNAL OF IMMUNOLOGY

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

(2011) Fred A Wright et al.   NATURE GENETICS

The Human Serum Metabolome

(2011) Nikolaos Psychogios et al.   PLoS One

Dysfunctional CFTR Alters the Bactericidal Activity of Human Macrophages against Pseudomonas aeruginosa

(2011) Paola Del Porto et al.   PLoS One

Increased Oxidative Stress Induces Apoptosis in Human Cystic Fibrosis Cells

(2011) Mathilde Rottner et al.   PLoS One

Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance

(2011) O. A. Itani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acid and base secretion in freshly excised nasal tissue from cystic fibrosis patients with ΔF508 mutation

(2011) Do-Yeon Cho et al.   International Forum of Allergy & Rhinology

CFTR Inhibition Provokes an Inflammatory Response Associated with an Imbalance of the Annexin A1 Pathway

(2010) Jesmond Dalli et al.   AMERICAN JOURNAL OF PATHOLOGY

Cystic fibrosis transmembrane conductance regulator is involved in airway epithelial wound repair

(2010) Katherine R. Schiller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Transient Receptor Potential Canonical Channel 6 Links Ca2+Mishandling to Cystic Fibrosis Transmembrane Conductance Regulator Channel Dysfunction in Cystic Fibrosis

(2010) Fabrice Antigny et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Loss of Anion Transport without Increased Sodium Absorption Characterizes Newborn Porcine Cystic Fibrosis Airway Epithelia

(2010) Jeng-Haur Chen et al.   CELL

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Critical role of cytosolic phospholipase A2  in bronchial mucus hypersecretion in CFTR-deficient mice

(2010) F. Dif et al.   EUROPEAN RESPIRATORY JOURNAL

Cystic fibrosis transmembrane conductance regulator (CFTR) expression in human platelets: impact on mediators and mechanisms of the inflammatory response

(2010) Domenico Mattoscio et al.   FASEB JOURNAL

MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits

(2010) Antonio Recchiuti et al.   FASEB JOURNAL

The Cystic Fibrosis Transmembrane Conductance Regulator Impedes Proteolytic Stimulation of the Epithelial Na+Channel

(2010) Martina Gentzsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Glucose Suppresses Epidermal Growth Factor Receptor/Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and Attenuates Corneal Epithelial Wound Healing

(2009) K.-P. Xu et al.   DIABETES

Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4

(2009) Robert B. Zurier et al.   FASEB JOURNAL

Disease-causing Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator Determine the Functional Responses of Alveolar Macrophages

(2009) Ludmila V. Deriy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans

(2009) T. Morris et al.   JOURNAL OF IMMUNOLOGY

Bronchiectasis in Infants and Preschool Children Diagnosed with Cystic Fibrosis after Newborn Screening

(2009) Stephen M. Stick et al.   JOURNAL OF PEDIATRICS

Dysfunction of mitochondria Ca2+ uptake in cystic fibrosis airway epithelial cells

(2009) Fabrice Antigny et al.   MITOCHONDRION

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Eicosanoid Release Is Increased by Membrane Destabilization and CFTR Inhibition in Calu-3 Cells

(2009) Florence Borot et al.   PLoS One

EGF and K+ channel activity control normal and cystic fibrosis bronchial epithelia repair

(2008) Nguyen Thu Ngan Trinh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

LXA4 stimulates ZO-1 expression and transepithelial electrical resistance in human airway epithelial (16HBE14o-) cells

(2008) Yael Grumbach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Airway Lipoxin A4Generation and Lipoxin A4Receptor Expression Are Decreased in Severe Asthma

(2008) Anna Planagumà et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macrophages Directly Contribute to the Exaggerated Inflammatory Response in Cystic Fibrosis Transmembrane Conductance Regulator−/−Mice

(2008) Emanuela M. Bruscia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Oxidative Stress CausesIL8Promoter Hyperacetylation in Cystic Fibrosis Airway Cell Models

(2008) Toni R. Bartling et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Endoplasmic Reticulum Stress in Disease Pathogenesis

(2008) Jonathan H. Lin et al.   Annual Review of Pathology-Mechanisms of Disease

Expression of Cyclooxygenase and Lipoxygenase Enzymes in Sinonasal Mucosa of Patients With Cystic Fibrosis

(2008) Jonathan M. Owens et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma

(2008) Haruka Aoki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP

(2008) J. Bystrom et al.   BLOOD

Annexin-A1: a pivotal regulator of the innate and adaptive immune systems

(2008) F D'Acquisto et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adenosine and Adenosine Receptors in the Pathomechanism and Treatment of Respiratory Diseases

(2008) G. Vass et al.   CURRENT MEDICINAL CHEMISTRY

Lipoxin A4 and interleukin-8 levels in cystic fibrosis sputum after antibiotherapy

(2008) Raphaël Chiron et al.   Journal of Cystic Fibrosis

Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis

(2008) Paul M Quinton   LANCET

Dysfunction of Nrf-2 in CF Epithelia Leads to Excess Intracellular H2O2 and Inflammatory Cytokine Production

(2008) Junnan Chen et al.   PLoS One

Impact of oxidative stress on lung diseases

(2008) Hee Sun PARK et al.   RESPIROLOGY

CISD1 codifies a mitochondrial protein upregulated by the CFTR channel

(2007) Guillermo L. Taminelli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR

(2007) Fabrice Antigny et al.   CELL CALCIUM

Oxidative stress induces extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase in cystic fibrosis lung epithelial cells: Potential mechanism for excessive IL-8 expression

(2007) Emilie Boncoeur et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Upregulated expression of ENaC in human CF nasal epithelium

(2007) Nadine Bangel et al.   Journal of Cystic Fibrosis