Resolution metabolomes activated by hypoxic environment

Resolvin E1 and its precursor 18 R -HEPE restore mitochondrial function in inflammation

(2018) Matthias Hecker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Splenic leukocytes define the resolution of inflammation in heart failure

(2018) Ganesh V. Halade et al.   Science Signaling

Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury

(2018) Michael Koeppen et al.   Nature Communications

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

(2018) Oliver Werz et al.   Nature Communications

Splenic leukocytes define the resolution of inflammation in heart failure

(2018) Ganesh V. Halade et al.   Science Signaling

Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation

(2018) Dorien Kiers et al.   EBioMedicine

Inhibition of neogenin fosters resolution of inflammation and tissue regeneration

(2018) Martin Schlegel et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice

(2018) Satoshi Deyama et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Resolution of sickle cell disease–associated inflammation and tissue damage with 17R-resolvin D1

(2018) Alessandro Matte et al.   BLOOD

DEL-1 promotes macrophage efferocytosis and clearance of inflammation

(2018) Ioannis Kourtzelis et al.   NATURE IMMUNOLOGY

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

(2018) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hemin impairs resolution of inflammation via microRNA-144-3p-dependent downregulation of ALX/FPR2

(2018) Guixiang Sun et al.   TRANSFUSION

Lipoxin and Resolvin Receptors Transducing the Resolution of Inflammation in Cardiovascular Disease

(2018) John Pirault et al.   Frontiers in Pharmacology

The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1

(2017) Kátia M. Lima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

(2017) Pranvera Sadiku et al.   JOURNAL OF CLINICAL INVESTIGATION

Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage

(2017) Che-Feng Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

Relationship between the omega-3 index and specialized pro-resolving lipid mediators in patients with peripheral arterial disease taking fish oil supplements

(2017) Melinda S. Schaller et al.   Journal of Clinical Lipidology

Special pro-resolving mediator (SPM) actions in regulating gastro-intestinal inflammation and gut mucosal immune responses

(2017) Ruth X. Wang et al.   MOLECULAR ASPECTS OF MEDICINE

Metabolic regulation of inflammation

(2017) Timo Gaber et al.   Nature Reviews Rheumatology

A cluster of immunoresolvents links coagulation to innate host defense in human blood

(2017) Paul C. Norris et al.   Science Signaling

Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice

(2017) Viola Neudecker et al.   Science Translational Medicine

A cluster of immunoresolvents links coagulation to innate host defense in human blood

(2017) Paul C. Norris et al.   Science Signaling

Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal

(2016) Evanna L. Mills et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation

(2016) Bishuang Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage

(2016) Shenglong Cao et al.   STROKE

Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution

(2016) Bangwei Luo et al.   Nature Communications

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

(2016) Gabrielle Fredman et al.   Nature Communications

Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors

(2015) Jose Iglesias et al.   JOURNAL OF LIPID RESEARCH

Resolvin Infectious Inflammation by Targeting the Host Response

(2015) Craig R. Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of omega-3 and omega-6 fatty acids on human placental cytokine production

(2015) S.M. Melody et al.   PLACENTA

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

(2014) Romain A. Colas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice

(2014) Yukako Tani et al.   FASEB JOURNAL

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Cutting Edge: Parathyroid Hormone Facilitates Macrophage Efferocytosis in Bone Marrow via Proresolving Mediators Resolvin D1 and Resolvin D2

(2014) L. K. McCauley et al.   JOURNAL OF IMMUNOLOGY

Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells

(2014) Andrea Dichlberger et al.   JOURNAL OF LIPID RESEARCH

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4synthesis by inhibiting a calcium-activated kinase pathway

(2014) Gabrielle Fredman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospholipase A2 regulates eicosanoid class switching during inflammasome activation

(2014) P. C. Norris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers

(2014) Philip A. Kramer et al.   Redox Biology

Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3

(2013) Y. Isobe et al.   JOURNAL OF BIOCHEMISTRY

Lymphoid tissue phospholipase A2group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators

(2013) Yoshimi Miki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium

(2013) Tobias Eckle et al.   PLOS BIOLOGY

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen sulfide and resolution of acute inflammation: A comparative study utilizing a novel fluorescent probe

(2012) Neil Dufton et al.   Scientific Reports

Targeting Hypoxia-induced Inflammation

(2011) Holger K. Eltzschig   ANESTHESIOLOGY

Resolvin E1 Regulates Adenosine Diphosphate Activation of Human Platelets

(2010) Gabrielle Fredman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits

(2010) Antonio Recchiuti et al.   FASEB JOURNAL