Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL‐1 signaling pathway

Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry

(2019) Matteo Guerra et al.   ACS Central Science

Muco-Obstructive Lung Diseases

(2019) Richard C. Boucher   NEW ENGLAND JOURNAL OF MEDICINE

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

(2019) Charles R. Esther et al.   Science Translational Medicine

Mucopurulent Triggering of the Airway Epithelium. Implications in Health and Cystic Fibrosis

(2018) Anita Balázs et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Infection Is Not Required for Mucoinflammatory Lung Disease in CFTR-Knockout Ferrets

(2018) Bradley H. Rosen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mucin Production and Hydration Responses to Mucopurulent Materials in Normal versus Cystic Fibrosis Airway Epithelia

(2018) Lubna H. Abdullah et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ion Channel Modulators in Cystic Fibrosis

(2018) Martina Gentzsch et al.   CHEST

Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis

(2018) A. Susanne Dittrich et al.   EUROPEAN RESPIRATORY JOURNAL

Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis

(2018) Samuel T. Montgomery et al.   Journal of Cystic Fibrosis

Progress in understanding mucus abnormalities in cystic fibrosis airways

(2018) Jeffrey J. Wine et al.   Journal of Cystic Fibrosis

Inflammation in cystic fibrosis: An update

(2018) Erica A. Roesch et al.   PEDIATRIC PULMONOLOGY

Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children

(2018) Marianne S. Muhlebach et al.   PLoS Pathogens

Anakinra Therapy for Non-cancer Inflammatory Diseases

(2018) Giulio Cavalli et al.   Frontiers in Pharmacology

Interleukin-1 receptor antagonist levels predict favorable outcome after bermekimab, a first-in-class true human interleukin-1α antibody, in a phase III randomized study of advanced colorectal cancer

(2018) Razelle Kurzrock et al.   OncoImmunology

An informative intragenic microsatellite marker suggests the IL-1 receptor as a genetic modifier in cystic fibrosis

(2017) Frauke Stanke et al.   EUROPEAN RESPIRATORY JOURNAL

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

Lung Clearance Index and Structural Lung Disease on Computed Tomography in Early Cystic Fibrosis

(2016) Kathryn A. Ramsey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypoxia and sterile inflammation in cystic fibrosis airways: mechanisms and potential therapies

(2016) Samuel T. Montgomery et al.   EUROPEAN RESPIRATORY JOURNAL

Cystic fibrosis

(2016) J Stuart Elborn   LANCET

Interleukin 1α and the inflammatory process

(2016) Nelson C Di Paolo et al.   NATURE IMMUNOLOGY

Early detection and sensitive monitoring of CF lung disease: Prospects of improved and safer imaging

(2016) Marcus A. Mall et al.   PEDIATRIC PULMONOLOGY

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

(2016) Mausita Karmakar et al.   Nature Communications

Newborn screening for cystic fibrosis

(2016) Carlo Castellani et al.   Lancet Respiratory Medicine

Differential ASC Requirements Reveal a Key Role for Neutrophils and a Noncanonical IL-1β Response to Pseudomonas aeruginosa

(2015) Yash R Patankar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxic Epithelial Necrosis Triggers Neutrophilic Inflammation via IL-1 Receptor Signaling in Cystic Fibrosis Lung Disease

(2015) Benedikt Fritzsching et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Safety, pharmacokinetics, and preliminary efficacy of a specific anti-IL-1alpha therapeutic antibody (MABp1) in patients with type 2 diabetes mellitus

(2015) Katharina Timper et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction

(2015) Veronica Marcos et al.   MEDIATORS OF INFLAMMATION

Five years of experience with biochemical cystic fibrosis newborn screening based on IRT/PAP in Germany

(2015) Olaf Sommerburg et al.   PEDIATRIC PULMONOLOGY

Open-Label Trial of MABp1, a True Human Monoclonal Antibody Targeting Interleukin 1α, for the Treatment of Psoriasis

(2015) Kyle M. Coleman et al.   JAMA Dermatology

IL-1β induction of MUC5AC gene expression is mediated by CREB and NF-κB and repressed by dexamethasone

(2014) Yajun Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lack of Neutrophil Elastase Reduces Inflammation, Mucus Hypersecretion, and Emphysema, but Not Mucus Obstruction, in Mice with Cystic Fibrosis–like Lung Disease

(2014) Stefanie Gehrig et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Magnetic Resonance Imaging Detects Changes in Structure and Perfusion, and Response to Therapy in Early Cystic Fibrosis Lung Disease

(2014) Mark O. Wielpütz et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CFTR: cystic fibrosis and beyond

(2014) M. A. Mall et al.   EUROPEAN RESPIRATORY JOURNAL

Lung Phenotype of Juvenile and Adult Cystic Fibrosis Transmembrane Conductance Regulator–Knockout Ferrets

(2013) Xingshen Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Risk Factors for Bronchiectasis in Children with Cystic Fibrosis

(2013) Peter D. Sly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early lung disease in cystic fibrosis

(2013) Hartmut Grasemann et al.   Lancet Respiratory Medicine

The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines

(2013) Busun Kim et al.   Frontiers in Immunology

Early Cystic Fibrosis Lung Disease Detected by Bronchoalveolar Lavage and Lung Clearance Index

(2012) Yvonne Belessis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil Elastase Degrades Cystic Fibrosis Transmembrane Conductance Regulator via Calpains and Disables Channel FunctionIn VitroandIn Vivo

(2012) Mathieu Le Gars et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Innate immunity in cystic fibrosis lung disease

(2012) D. Hartl et al.   Journal of Cystic Fibrosis

Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation

(2012) A Livraghi-Butrico et al.   Mucosal Immunology

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

CFTR Regulates Early Pathogenesis of Chronic Obstructive Lung Disease in βENaC-Overexpressing Mice

(2012) Bjarki Johannesson et al.   PLoS One

Lung function is abnormal in 3-month-old infants with cystic fibrosis diagnosed by newborn screening

(2012) Ah-Fong Hoo et al.   THORAX

IL-1 family cytokines trigger sterile inflammatory disease

(2012) John R. Lukens et al.   Frontiers in Immunology

IL-1α/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in Mice

(2011) Fernando M. Botelho et al.   PLoS One

NF-κB Mediates IL-1β– and IL-17A–InducedMUC5BExpression in Airway Epithelial Cells

(2010) Tomoyuki Fujisawa et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Genes that determine immunology and inflammation modify the basic defect of impaired ion conductance in cystic fibrosis epithelia

(2010) F. Stanke et al.   JOURNAL OF MEDICAL GENETICS

Pneumonia in a patient with familial Mediterranean fever successfully treated with anakinra—case report and review

(2010) Stefanie Hennig et al.   RHEUMATOLOGY INTERNATIONAL

Lung Disease at Diagnosis in Infants with Cystic Fibrosis Detected by Newborn Screening

(2009) Peter D. Sly et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of Airway MUC5AC Expression by IL-1  and IL-17A; the NF- B Paradigm

(2009) T. Fujisawa et al.   JOURNAL OF IMMUNOLOGY

Bronchiectasis in Infants and Preschool Children Diagnosed with Cystic Fibrosis after Newborn Screening

(2009) Stephen M. Stick et al.   JOURNAL OF PEDIATRICS

Anakinra for Rheumatoid Arthritis: A Systematic Review

(2009) M. MERTENS et al.   JOURNAL OF RHEUMATOLOGY

IL1Bpolymorphisms modulate cystic fibrosis lung disease

(2009) Hara Levy et al.   PEDIATRIC PULMONOLOGY

Preventive but Not Late Amiloride Therapy Reduces Morbidity and Mortality of Lung Disease in βENaC-overexpressing Mice

(2008) Zhe Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of Cilia, Mucus, and Airway Surface Liquid in Mucociliary Dysfunction: Lessons from Mouse Models

(2008) Marcus A. Mall   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Development of Chronic Bronchitis and Emphysema in β-Epithelial Na+Channel–Overexpressing Mice

(2007) Marcus A. Mall et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Modelling Dysregulated Na+Absorption in Airway Epithelial Cells with Mucosal Nystatin Treatment

(2007) Alessandra Livraghi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY