Vx-809/Vx-770 treatment reduces inflammatory response to Pseudomonas aeruginosa in primary differentiated cystic fibrosis bronchial epithelial cells
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Title
Vx-809/Vx-770 treatment reduces inflammatory response to Pseudomonas aeruginosa in primary differentiated cystic fibrosis bronchial epithelial cells
Authors
Keywords
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Journal
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Volume 314, Issue 4, Pages L635-L641
Publisher
American Physiological Society
Online
2018-01-09
DOI
10.1152/ajplung.00198.2017
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Note: Only part of the references are listed.- Quorum Sensing Down-Regulation Counteracts the Negative Impact of Pseudomonas aeruginosa on CFTR Channel Expression, Function and Rescue in Human Airway Epithelial Cells
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- Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy
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- Effect of ivacaftor on CFTR forms with missense mutations associated with defects in protein processing or function
- (2013) Fredrick Van Goor et al. Journal of Cystic Fibrosis
- The Level of p38α Mitogen-Activated Protein Kinase Activation in Airway Epithelial Cells Determines the Onset of Innate Immune Responses to Planktonic and Biofilm Pseudomonas aeruginosa
- (2013) Trevor Beaudoin et al. JOURNAL OF INFECTIOUS DISEASES
- Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia
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- Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
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- Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for theF508del-CFTRmutation
- (2011) J P Clancy et al. THORAX
- Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Enhances Activation of p38 and ERK MAPKs, Increasing Interleukin-6 Synthesis in Airway Epithelial Cells Exposed toPseudomonas aeruginosa
- (2010) Julie Bérubé et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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