Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis

Use of ibuprofen to assess inflammatory biomarkers in induced sputum: Implications for clinical trials in cystic fibrosis

(2015) James F. Chmiel et al.   Journal of Cystic Fibrosis

Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy

(2015) André M. Cantin et al.   Journal of Cystic Fibrosis

Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction

(2015) Veronica Marcos et al.   MEDIATORS OF INFLAMMATION

A randomized double blind, placebo controlled phase 2 trial of BIIL 284 BS (an LTB4 receptor antagonist) for the treatment of lung disease in children and adults with cystic fibrosis

(2014) M.W. Konstan et al.   Journal of Cystic Fibrosis

Candidate Markers Associated with the Probability of Future Pulmonary Exacerbations in Cystic Fibrosis Patients

(2014) Gabriella Wojewodka et al.   PLoS One

BIIL 284 reduces neutrophil numbers but increases P. aeruginosa bacteremia and inflammation in mouse lungs

(2013) Gerd Döring et al.   Journal of Cystic Fibrosis

Lung clearance index: Evidence for use in clinical trials in cystic fibrosis

(2013) L. Kent et al.   Journal of Cystic Fibrosis

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

Human Neutrophil Elastase Degrades SPLUNC1 and Impairs Airway Epithelial Defense against Bacteria

(2013) Di Jiang et al.   PLoS One

Sputum Biomarkers of Inflammation and Lung Function Decline in Children with Cystic Fibrosis

(2012) Scott D. Sagel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil Elastase Degrades Cystic Fibrosis Transmembrane Conductance Regulator via Calpains and Disables Channel FunctionIn VitroandIn Vivo

(2012) Mathieu Le Gars et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

LTB4 Is a Signal-Relay Molecule during Neutrophil Chemotaxis

(2012) Philippe V. Afonso et al.   DEVELOPMENTAL CELL

Efficacy, safety and effect on biomarkers of AZD9668 in cystic fibrosis

(2012) J. Stuart Elborn et al.   EUROPEAN RESPIRATORY JOURNAL

Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis

(2012) Richard B. Moss et al.   Journal of Cystic Fibrosis

Inhaled aztreonam lysine vs. inhaled tobramycin in cystic fibrosis: A comparative efficacy trial

(2012) Baroukh M. Assael et al.   Journal of Cystic Fibrosis

Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and Fc R signaling

(2012) C. D. Sadik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosis

(2012) David A Ngan et al.   BMC Pulmonary Medicine

Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation

(2011) Christian D. Sadik et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Role of LTB4 in the pathogenesis of elastase-induced murine pulmonary emphysema

(2010) Y. Michael Shim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation

(2010) R. J. Snelgrove et al.   SCIENCE

Targeting neutrophil elastase in cystic fibrosis

(2008) Emer Kelly et al.   EXPERT OPINION ON THERAPEUTIC TARGETS