The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms

Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes—The TrialNet Experience

(2018) Carla J. Greenbaum et al.   DIABETES

C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase

(2018) Beverley M. Shields et al.   DIABETES CARE

A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk

(2018) Maria J. Redondo et al.   DIABETES CARE

Type 1 diabetes

(2018) Linda A DiMeglio et al.   LANCET

Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

(2018) Sergio Gonzalez-Duque et al.   Cell Metabolism

Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes

(2017) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

β Cells Persist in T1D Pancreata Without Evidence of Ongoing β-Cell Turnover or Neogenesis

(2017) Carol J Lam et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002–2012

(2017) Elizabeth J. Mayer-Davis et al.   NEW ENGLAND JOURNAL OF MEDICINE

The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1

(2017) Jay M Sosenko et al.   PEDIATRIC DIABETES

Elevations in the Fasting Serum Proinsulin–to–C-Peptide Ratio Precede the Onset of Type 1 Diabetes

(2016) Emily K. Sims et al.   DIABETES CARE

Fall in C-Peptide During First 4 Years From Diagnosis of Type 1 Diabetes: Variable Relation to Age, HbA 1c , and Insulin Dose

(2016) Wei Hao et al.   DIABETES CARE

Dissecting heterogeneity in paediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low-risk human leukocyte antigen (HLA) genotypes

(2016) M. J. Redondo et al.   DIABETIC MEDICINE

Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns

(2016) Deepali Malhotra et al.   NATURE IMMUNOLOGY

Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro

(2015) Lars Krogvold et al.   DIABETES

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Defining Pathways for Development of Disease-Modifying Therapies in Children With Type 1 Diabetes: A Consensus Report

(2015) Diane K. Wherrett et al.   DIABETES CARE

CD4 + T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion

(2015) Francois P. Legoux et al.   IMMUNITY

Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients

(2015) Mark R. Rigby et al.   JOURNAL OF CLINICAL INVESTIGATION

Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes

(2014) Sefina Arif et al.   DIABETES

Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study

(2014) Lars Krogvold et al.   DIABETOLOGIA

Patterns of  -Cell Autoantibody Appearance and Genetic Associations During the First Years of Life

(2013) J. Ilonen et al.   DIABETES

Teplizumab Preserves C-Peptide in Recent-Onset Type 1 Diabetes: Two-Year Results From the Randomized, Placebo-Controlled Protege Trial

(2013) W. Hagopian et al.   DIABETES

Increasing Incidence of Type 1 Diabetes in Youth: Twenty years of the Philadelphia Pediatric Diabetes Registry

(2013) T. H. Lipman et al.   DIABETES CARE

The diagnosis of insulitis in human type 1 diabetes

(2013) M. L. Campbell-Thompson et al.   DIABETOLOGIA

Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial

(2013) Mark R Rigby et al.   Lancet Diabetes & Endocrinology

Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes

(2012) J. M. M. Howson et al.   DIABETES

Fall in C-Peptide During First 2 Years From Diagnosis: Evidence of at Least Two Distinct Phases From Composite Type 1 Diabetes TrialNet Data

(2012) C. J. Greenbaum et al.   DIABETES

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

The Application of the Diabetes Prevention Trial-Type 1 Risk Score for Identifying a Preclinical State of Type 1 Diabetes

(2012) J. M. Sosenko et al.   DIABETES CARE

Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes

(2012) Martha Campbell-Thompson et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes

(2012) A.-G. Ziegler et al.   DIABETOLOGIA

The Epidemiology of Type 1 Diabetes in Children

(2012) Diana E. Stanescu et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Beta cell function and BMI in ethnically diverse children with newly diagnosed autoimmune type 1 diabetes

(2012) Maria J. Redondo et al.   PEDIATRIC DIABETES

Quantification of islet size and architecture

(2012) German Kilimnik et al.   Islets

Genetic Analysis of Adult-Onset Autoimmune Diabetes

(2011) J. M. M. Howson et al.   DIABETES

Validation of the Diabetes Prevention Trial–Type 1 Risk Score in the TrialNet Natural History Study

(2011) Jay M. Sosenko et al.   DIABETES CARE

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

(2011) Tihamer Orban et al.   LANCET

Insulitis in human type 1 diabetes

(2011) Peter In't Veld   Islets

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Age-Related Differences in the Frequency of Ketoacidosis at Diagnosis of Type 1 Diabetes in Children and Adolescents

(2010) A. Hekkala et al.   DIABETES CARE

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass

(2010) B. Keymeulen et al.   DIABETOLOGIA

Epidemiology of Type 1 Diabetes

(2010) David M. Maahs et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Trends of Earlier and Later Responses of C-peptide to Oral Glucose Challenges With Progression to Type 1 Diabetes in Diabetes Prevention Trial-Type 1 Participants

(2009) J. M. Sosenko et al.   DIABETES CARE

Incident Dysglycemia and Progression to Type 1 Diabetes Among Participants in the Diabetes Prevention Trial-Type 1

(2009) J. M. Sosenko et al.   DIABETES CARE

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES

The TrialNet Natural History Study of the Development of Type 1 Diabetes: objectives, design, and initial results

(2008) Jeffrey L Mahon et al.   PEDIATRIC DIABETES

Extent of Beta Cell Destruction Is Important but Insufficient to Predict the Onset of Type 1 Diabetes Mellitus

(2008) David J. Klinke   PLoS One