Biomarkers of islet beta cell stress and death in type 1 diabetes

Elevated unmethylated and methylated insulin DNA are unique markers of A + β + ketosis prone diabetes

(2018) Surya N. Mulukutla et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Serum miRNA levels are related to glucose homeostasis and islet autoantibodies in children with high risk for type 1 diabetes

(2018) Linda Åkerman et al.   PLoS One

Beta Cell Death by Cell-free DNA and Outcome After Clinical Islet Transplantation

(2018) Boris L. Gala-Lopez et al.   TRANSPLANTATION

Glucokinase Gene May Be a More Suitable Target Than the Insulin Gene for Detection of β Cell Death

(2017) Jana Sklenarova et al.   ENDOCRINOLOGY

Measurement of Pro-Islet Amyloid Polypeptide (1–48) in Diabetes and Islet Transplants

(2017) Jaques A. Courtade et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue

(2017) Prashanth Vallabhajosyula et al.   JOURNAL OF CLINICAL INVESTIGATION

Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type–specific methylation in enhancers

(2017) Daniel Neiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determining the contents and cell origins of apoptotic bodies by flow cytometry

(2017) Lanzhou Jiang et al.   Scientific Reports

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes

(2017) Marta Garcia-Contreras et al.   Scientific Reports

Unmethylated Insulin DNA Is Elevated After Total Pancreatectomy With Islet Autotransplantation: Assessment of a Novel Beta Cell Marker

(2016) M. D. Bellin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

(2016) Chiara Cianciaruso et al.   DIABETES

Elevations in the Fasting Serum Proinsulin–to–C-Peptide Ratio Precede the Onset of Type 1 Diabetes

(2016) Emily K. Sims et al.   DIABETES CARE

Identification of tissue-specific cell death using methylation patterns of circulating DNA

(2016) Roni Lehmann-Werman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes

(2016) Renecia A. Watkins et al.   Translational Research

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes

(2016) Flora Brozzi et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

miRNA-375 a Sensor of Glucotoxicity Is Altered in the Serum of Children with Newly Diagnosed Type 1 Diabetes

(2016) Lucien Marchand et al.   Journal of Diabetes Research

Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes

(2016) John A. Olsen et al.   PLoS One

Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio

(2016) Annelien Van Dalem et al.   PLoS One

Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study

(2016) Attila A. Seyhan et al.   Scientific Reports

Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells

(2015) Claudiane Guay et al.   Cell Communication and Signaling

Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes

(2015) Marisa M. Fisher et al.   DIABETES

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Development of an Enhanced Sensitivity Bead-Based Immunoassay for Real-Time In Vivo Detection of Pancreatic β-Cell Death

(2015) Olivier R. Costa et al.   ENDOCRINOLOGY

β Cell death and dysfunction during type 1 diabetes development in at-risk individuals

(2015) Kevan C. Herold et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development

(2015) Mathieu Latreille et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Minireview: Emerging Roles for Extracellular Vesicles in Diabetes and Related Metabolic Disorders

(2015) Alexander J. Lakhter et al.   MOLECULAR ENDOCRINOLOGY

A New Approach for Diagnosing Type 1 Diabetes in Autoantibody-Positive Individuals Based on Prediction and Natural History

(2014) Jay M. Sosenko et al.   DIABETES CARE

Diabetes-Associated MicroRNAs in Pediatric Patients With Type 1 Diabetes Mellitus: A Cross-Sectional Cohort Study

(2014) Julia Osipova et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Tissue-Specific Methylation of Human Insulin Gene and PCR Assay for Monitoring Beta Cell Death

(2014) Mohamed I. Husseiny et al.   PLoS One

Insulitis in human type 1 diabetes: a comparison between patients and animal models

(2014) Peter In’t Veld   Seminars in Immunopathology

Detection of Islet β-Cell Death in Vivo by Multiplex PCR Analysis of Differentially Methylated DNA

(2013) Marisa M. Fisher et al.   ENDOCRINOLOGY

Circulating miR-375 as a Biomarker of β-Cell Death and Diabetes in Mice

(2013) Suheda Erener et al.   ENDOCRINOLOGY

Circulating microRNAs as novel biomarkers for diabetes mellitus

(2013) Claudiane Guay et al.   Nature Reviews Endocrinology

MicroRNA Expression in Alpha and Beta Cells of Human Pancreatic Islets

(2013) Dagmar Klein et al.   PLoS One

Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2012) S. A. Tersey et al.   DIABETES

The Application of the Diabetes Prevention Trial-Type 1 Risk Score for Identifying a Preclinical State of Type 1 Diabetes

(2012) J. M. Sosenko et al.   DIABETES CARE

Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2012) D. L. Eizirik et al.   DIABETOLOGIA

Proinsulin-to-C-peptide ratio versus proinsulin-to-insulin ratio in the prediction of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS)

(2011) R. C. Loopstra-Masters et al.   DIABETOLOGIA

Detection of   cell death in diabetes using differentially methylated circulating DNA

(2011) E. M. Akirav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group

(2010) J. B. Matthews et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Proinsulin/C-peptide ratio, glucagon and remission in new-onset Type 1 diabetes mellitus in young adults

(2010) A. Schölin et al.   DIABETIC MEDICINE

Insulin Gene Expression Is Regulated by DNA Methylation

(2009) Akio Kuroda et al.   PLoS One