Candidate genes for type 1 diabetes modulate pancreatic islet inflammation andβ-cell apoptosis

Weighing in on autoimmune disease: Big data tip the scale

(2013) Calliope A Dendrou et al.   NATURE MEDICINE

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

(2013) Tatiane C. Nogueira et al.   PLoS Genetics

On the Immense Variety and Complexity of Circumstances Conditioning Pancreatic  -Cell Apoptosis in Type 1 Diabetes

(2012) D. L. Eizirik et al.   DIABETES

Through the Fog: Recent Clinical Trials to Preserve  -Cell Function in Type 1 Diabetes

(2012) C. J. Greenbaum et al.   DIABETES

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

(2012) R. Bergholdt et al.   DIABETES

Changes in MicroRNA Expression Contribute to Pancreatic  -Cell Dysfunction in Prediabetic NOD Mice

(2012) E. Roggli et al.   DIABETES

Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes

(2012) Martha Campbell-Thompson et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Epigenetics in autoimmune diseases with focus on type 1 diabetes

(2012) Mary Ngoc Dang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction

(2012) P. Ylipaasto et al.   DIABETOLOGIA

Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1

(2012) S. J. Richardson et al.   DIABETOLOGIA

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

(2012) Michael Volkmar et al.   EMBO JOURNAL

Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults

(2012) Yisheng Yang et al.   EMBO Molecular Medicine

Identifying disease related sub-pathways for analysis of genome-wide association studies

(2012) Chunquan Li et al.   GENE

Post-transcriptional control of candidate risk genes for type 1 diabetes by rare genetic variants

(2012) V M de Jong et al.   GENES AND IMMUNITY

Cellular and molecular determinants for the development of natural and induced regulatory T cells

(2012) Xiaomei Yuan et al.   HUMAN IMMUNOLOGY

The Promise and Limitations of Genome-wide Association Studies

(2012) Christine Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of STAT4 rs7574865 polymorphism with autoimmune diseases: a meta-analysis

(2012) Ya-ling Liang et al.   MOLECULAR BIOLOGY REPORTS

Viral immune modulators perturb the human molecular network by common and unique strategies

(2012) Andreas Pichlmair et al.   NATURE

Pathway analysis of genomic data: concepts, methods, and prospects for future development

(2012) Vijay K. Ramanan et al.   TRENDS IN GENETICS

USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis

(2012) I Santin et al.   Cell Death & Disease

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Independent component and pathway-based analysis of miRNA-regulated gene expression in a model of type 1 diabetes

(2011) Claus H Bang-Berthelsen et al.   BMC GENOMICS

Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes

(2011) K. Lind et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Genetics of the HLA Region in the Prediction of Type 1 Diabetes

(2011) Janelle A. Noble et al.   Current Diabetes Reports

Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes

(2011) Sridevi Devaraj et al.   CYTOKINE

An Interferon-Induced Helicase (IFIH1) Gene Polymorphism Associates With Different Rates of Progression From Autoimmunity to Type 1 Diabetes

(2011) C. Winkler et al.   DIABETES

MicroRNAs in  -Cell Biology, Insulin Resistance, Diabetes and Its Complications

(2011) S. L. Fernandez-Valverde et al.   DIABETES

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic  -Cell Apoptosis via Regulation of the BH3-Only Protein Bim

(2011) I. Santin et al.   DIABETES

Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity

(2011) Guido Sebastiani et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases

(2011) S L Musone et al.   GENES AND IMMUNITY

Modulation of innate immunity in human pancreatic islets infected with enterovirus in vitro

(2011) Oskar Skog et al.   JOURNAL OF MEDICAL VIROLOGY

Leprosy and the natural selection for psoriasis

(2011) Ioannis D. Bassukas et al.   MEDICAL HYPOTHESES

Initial impact of the sequencing of the human genome

(2011) Eric S. Lander   NATURE

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

Genome–virome interactions: examining the role of common viral infections in complex disease

(2011) Ellen F. Foxman et al.   NATURE REVIEWS MICROBIOLOGY

Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci

(2011) Alexandra Zhernakova et al.   PLoS Genetics

Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis

(2011) Vardhman K. Rakyan et al.   PLoS Genetics

Genetics of Type 1 Diabetes: What's Next?

(2010) F. Pociot et al.   DIABETES

Specific gene expression signature associated with development of autoimmune type-I diabetes using whole-blood microarray analysis

(2010) F Reynier et al.   GENES AND IMMUNITY

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells

(2010) S A Long et al.   GENES AND IMMUNITY

Etiology of Type 1 Diabetes

(2010) John A. Todd   IMMUNITY

Endogenous toll-like receptor ligands and their biological significance

(2010) Li Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TLR9 Blockade Inhibits Activation of Diabetogenic CD8+ T Cells and Delays Autoimmune Diabetes

(2010) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases

(2010) Jin-Hui Tao et al.   MOLECULAR BIOLOGY REPORTS

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

(2010) Matthias Heinig et al.   NATURE

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes

(2010) Kate Downes et al.   PLoS One

Genetically Dependent ERBB3 Expression Modulates Antigen Presenting Cell Function and Type 1 Diabetes Risk

(2010) Hongjie Wang et al.   PLoS One

Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells

(2009) Mónica García et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis

(2009) E N Gurzov et al.   CELL DEATH AND DIFFERENTIATION

Cytokines Interleukin-1  and Tumor Necrosis Factor-  Regulate Different Transcriptional and Alternative Splicing Networks in Primary  -Cells

(2009) F. Ortis et al.   DIABETES

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic  -Cell Apoptosis

(2009) F. Moore et al.   DIABETES

Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes

(2009) S. Devaraj et al.   DIABETOLOGIA

Predicting human height by Victorian and genomic methods

(2009) Yurii S Aulchenko et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The type I diabetes association of the IL2RA locus

(2009) H-Q Qu et al.   GENES AND IMMUNITY

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA

(2009) Maikel L. Colli et al.   HUMAN MOLECULAR GENETICS

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

(2009) Chris Wallace et al.   NATURE GENETICS

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Genetics of Type 1A Diabetes

(2009) Patrick Concannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Common Genetic Fingerprint in Leprosy and Crohn's Disease?

(2009) Erwin Schurr et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathway Analysis of GWAS Provides New Insights into Genetic Susceptibility to 3 Inflammatory Diseases

(2009) Hariklia Eleftherohorinou et al.   PLoS One

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

MDA5/RIG-I and virus recognition

(2008) Osamu Takeuchi et al.   CURRENT OPINION IN IMMUNOLOGY

Double-Stranded RNA Induces Pancreatic  -Cell Apoptosis by Activation of the Toll-Like Receptor 3 and Interferon Regulatory Factor 3 Pathways

(2008) Z. Dogusan et al.   DIABETES

Lymphocytes From Patients With Type 1 Diabetes Display a Distinct Profile of Chromatin Histone H3 Lysine 9 Dimethylation: An Epigenetic Study in Diabetes

(2008) F. Miao et al.   DIABETES

Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells

(2008) F. Ortis et al.   DIABETOLOGIA

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

(2008) E Y M G Fung et al.   GENES AND IMMUNITY

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

(2008) Jason D Cooper et al.   NATURE GENETICS

Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease

(2008) Deborah J. Smyth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon-  initiates type 1 diabetes in nonobese diabetic mice

(2008) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Toll-Like Receptor (TLR) 2 and TLR4 Expression in Monocytes from Patients with Type 1 Diabetes: Further Evidence of a Proinflammatory State

(2007) Sridevi Devaraj et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

(2007) R. E. Randall et al.   JOURNAL OF GENERAL VIROLOGY