Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions

(2019) Asbjørn Christophersen et al.   NATURE MEDICINE

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry

(2019) Nicolas Damond et al.   Cell Metabolism

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes

(2019) Yue J. Wang et al.   Cell Metabolism

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

(2019) Laura M. McLane et al.   Annual Review of Immunology

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

(2019) Kevan C. Herold et al.   NEW ENGLAND JOURNAL OF MEDICINE

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

(2019) Hyungseok Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enforcing the checkpoints

(2019) Peter S. Linsley et al.   Current Opinion in Endocrinology Diabetes and Obesity

T-cell Immunoglobulin and ITIM Domain Contributes to CD8+ T-cell Immunosenescence

(2018) Yangzi Song et al.   AGING CELL

Detection and Characterization of CD8+Autoreactive Memory Stem T Cells in Patients With Type 1 Diabetes

(2018) Debora Vignali et al.   DIABETES

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes

(2018) Lorraine Yeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibitory receptor expression on T cells as marker of disease activity and target to regulate effector cellular responses in Rheumatoid Arthritis

(2018) Luisina I. Onofrio et al.   Arthritis & Rheumatology

Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

(2018) Sergio Gonzalez-Duque et al.   Cell Metabolism

Identification and Analysis of Islet Antigen–Specific CD8+T Cells with T Cell Libraries

(2018) Hideki Ogura et al.   JOURNAL OF IMMUNOLOGY

Heterogeneity of circulating CD8 T-cells specific to islet, neo-antigen and virus in patients with type 1 diabetes mellitus

(2018) Sandra Laban et al.   PLoS One

Pathophysiological characteristics of preproinsulin-specific CD8+ T cells in subjects with juvenile-onset and adult-onset type 1 diabetes: A 1-year follow-up study

(2017) Mahinder Paul et al.   PEDIATRIC DIABETES

Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes

(2017) Mohammad Alhadj Ali et al.   Science Translational Medicine

A Practical Review of C-Peptide Testing in Diabetes

(2017) Emma Leighton et al.   Diabetes Therapy

A Practical Review of C-Peptide Testing in Diabetes

(2017) Emma Leighton et al.   Diabetes Therapy

Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis

(2017) Andreas Digre et al.   Scientific Reports

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

T cell exhaustion and immune-mediated disease—the potential for therapeutic exhaustion

(2016) Eoin F McKinney et al.   CURRENT OPINION IN IMMUNOLOGY

Fall in C-Peptide During First 4 Years From Diagnosis of Type 1 Diabetes: Variable Relation to Age, HbA 1c , and Insulin Dose

(2016) Wei Hao et al.   DIABETES CARE

Characterization of Diabetogenic CD8+ T Cells

(2016) Justin W. Garyu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytofkit: A Bioconductor Package for an Integrated Mass Cytometry Data Analysis Pipeline

(2016) Hao Chen et al.   PLoS Computational Biology

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

(2015) Jacob H. Levine et al.   CELL

Preproinsulin specific CD8+ T cells in subjects with latent autoimmune diabetes show lower frequency and different pathophysiological characteristics than those with type 1 diabetes

(2015) Naresh Sachdeva et al.   CLINICAL IMMUNOLOGY

T Cell Epitopes and Post-Translationally Modified Epitopes in Type 1 Diabetes

(2015) John W. McGinty et al.   Current Diabetes Reports

Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association

(2015) Richard A. Insel et al.   DIABETES CARE

Changes in T-cell subsets identify responders to FcR-nonbinding anti-CD3 mAb (teplizumab) in patients with type 1 diabetes

(2015) James E. Tooley et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immune Interventions to Preserve β Cell Function in Type 1 Diabetes

(2015) Mario R. Ehlers   JOURNAL OF INVESTIGATIVE MEDICINE

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

(2015) Eoin F. McKinney et al.   NATURE

Mapping the Diversity of Follicular Helper T Cells in Human Blood and Tonsils Using High-Dimensional Mass Cytometry Analysis

(2015) Michael T. Wong et al.   Cell Reports

CXCR3, CXCL10 and type 1 diabetes

(2014) Alessandro Antonelli et al.   CYTOKINE & GROWTH FACTOR REVIEWS

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

(2014) Ania Skowera et al.   DIABETES

Prevalence of Detectable C-Peptide According to Age at Diagnosis and Duration of Type 1 Diabetes

(2014) Asa K. Davis et al.   DIABETES CARE

CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes

(2014) Ghanashyam Sarikonda et al.   JOURNAL OF AUTOIMMUNITY

High-dimensional analysis of the murine myeloid cell system

(2014) Burkhard Becher et al.   NATURE IMMUNOLOGY

T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

(2014) Marcus Buggert et al.   PLoS Pathogens

Programmed Death-1 Is a Marker for Abnormal Distribution of Naive/Memory T Cell Subsets in HIV-1 Infection

(2013) G. Breton et al.   JOURNAL OF IMMUNOLOGY

Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization

(2013) Evan W Newell et al.   NATURE BIOTECHNOLOGY

Fall in C-Peptide During First 2 Years From Diagnosis: Evidence of at Least Two Distinct Phases From Composite Type 1 Diabetes TrialNet Data

(2012) C. J. Greenbaum et al.   DIABETES

Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial

(2012) K. C. Herold et al.   DIABETOLOGIA

Sorting Through Subsets

(2012) Christopher A. Klebanoff et al.   JOURNAL OF IMMUNOTHERAPY

Single Insulin-Specific CD8+ T Cells Show Characteristic Gene Expression Profiles in Human Type 1 Diabetes

(2011) S. Luce et al.   DIABETES

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Helios Expression Is a Marker of T Cell Activation and Proliferation

(2011) Tatiana Akimova et al.   PLoS One

Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell-Associated Epitopes Using Combinatorial MHC Multimers

(2010) J. H. Velthuis et al.   DIABETES

Prediction and Pathogenesis in Type 1 Diabetes

(2010) Anette-G. Ziegler et al.   IMMUNITY

A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

(2010) Eoin F McKinney et al.   NATURE MEDICINE

flowCore: a Bioconductor package for high throughput flow cytometry

(2009) Florian Hahne et al.   BMC BIOINFORMATICS

Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies

(2009) Simona Cernea et al.   CLINICAL IMMUNOLOGY

The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies

(2009) Denise L. Faustman et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The Frequency and Immunodominance of Islet-Specific CD8+ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment

(2008) E. Martinuzzi et al.   DIABETES

Clinical manifestations and beta cell function in Swedish diabetic children have remained unchanged during the last 25 years

(2008) Maria Nordwall et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Human Immune Memory to Yellow Fever and Smallpox Vaccination

(2008) Jens Wrammert et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF

(2008) C MALMESTROM et al.   JOURNAL OF NEUROIMMUNOLOGY