Viral infections in type 1 diabetes mellitus — why the β cells?

Persistent infection of human pancreatic cells with Coxsackievirus B4 is cured by fluoxetine

(2015) Enagnon Kazali Alidjinou et al.   ANTIVIRAL RESEARCH

The gut microbiota and Type 1 Diabetes

(2015) Elke Gülden et al.   CLINICAL IMMUNOLOGY

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

(2015) Laura Marroqui et al.   DIABETES

Function of Isolated Pancreatic Islets From Patients at Onset of Type 1 Diabetes: Insulin Secretion Can Be Restored After Some Days in a Nondiabetogenic Environment In Vitro

(2015) Lars Krogvold et al.   DIABETES

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Reduced Expression of the MDA5 GeneIFIH1Prevents Autoimmune Diabetes

(2015) Pamela J. Lincez et al.   DIABETES

Current Concepts on the Pathogenesis of Type 1 Diabetes—Considerations for Attempts to Prevent and Reverse the Disease

(2015) Mark A. Atkinson et al.   DIABETES CARE

Lessons from the mouse: potential contribution of bystander lymphocyte activation by viruses to human type 1 diabetes

(2015) Jessica A. Pane et al.   DIABETOLOGIA

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study

(2015) Jeffrey P. Krischer et al.   DIABETOLOGIA

Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease

(2015) Johanna Lempainen et al.   JOURNAL OF AUTOIMMUNITY

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

(2015) Suna Onengut-Gumuscu et al.   NATURE GENETICS

Early IFN type I response: Learning from microbial evasion strategies

(2015) Eliana M. Coccia et al.   SEMINARS IN IMMUNOLOGY

Recent progress in understanding coxsackievirus replication, dissemination, and pathogenesis

(2015) Jon Sin et al.   VIROLOGY

Interferon therapy in hepatitis C leading to chronic type 1 diabetes

(2015) Taiba Zornitzki   WORLD JOURNAL OF GASTROENTEROLOGY

Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes

(2015) Kenichi Izumi et al.   Nature Communications

Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells

(2015) Laura Marroqui et al.   eLife

TYK2 Promoter Variant and Diabetes Mellitus in the Japanese

(2015) Seiho Nagafuchi et al.   EBioMedicine

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

(2015) Laura Marroqui et al.   EBioMedicine

BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic  -Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

(2014) L. Marroqui et al.   DIABETES

Viral Infection of Engrafted Human Islets Leads to Diabetes

(2014) Glen R. Gallagher et al.   DIABETES

Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes

(2014) Lars Krogvold et al.   DIABETES

Molecular Signatures Differentiate Immune States in Type 1 Diabetic Families

(2014) Yi-Guang Chen et al.   DIABETES

A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

(2014) R. C. Ferreira et al.   DIABETES

Potential viral pathogenic mechanism in human type 1 diabetes

(2014) Darius A. Schneider et al.   DIABETOLOGIA

A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models

(2014) Pär G. Larsson et al.   DIABETOLOGIA

Pancreatic Pathology in Type 1 Diabetes Mellitus

(2014) Sarah J. Richardson et al.   ENDOCRINE PATHOLOGY

Developing a vaccine for Type 1 diabetes through targeting enteroviral infections

(2014) Heikki Hyöty et al.   Expert Review of Vaccines

Role of Viruses and Other Microbes in the Pathogenesis of Type 1 Diabetes

(2014) Anita Kondrashova et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Coxsackievirus can persist in murine pancreas by deletion of 5′ terminal genomic sequences

(2014) Steven Tracy et al.   JOURNAL OF MEDICAL VIROLOGY

Microbiology: Ditch the term pathogen

(2014) Arturo Casadevall et al.   NATURE

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

CTSH regulates  -cell function and disease progression in newly diagnosed type 1 diabetes patients

(2014) T. Floyel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enteroviruses, hygiene and type 1 diabetes: toward a preventive vaccine

(2014) Kristen M. Drescher et al.   REVIEWS IN MEDICAL VIROLOGY

Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?

(2014) Noel G. Morgan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion

(2013) Ezio Bonifacio et al.   ACTA DIABETOLOGICA

Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice

(2013) H. S. Quah et al.   DIABETES

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

(2013) Miriam Cnop et al.   DIABETES

Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes

(2013) S. Oikarinen et al.   DIABETES

Patterns of  -Cell Autoantibody Appearance and Genetic Associations During the First Years of Life

(2013) J. Ilonen et al.   DIABETES

Coxsackievirus B1 Is Associated With Induction of  -Cell Autoimmunity That Portends Type 1 Diabetes

(2013) O. H. Laitinen et al.   DIABETES

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation andβ-cell apoptosis

(2013) I. Santin et al.   DIABETES OBESITY & METABOLISM

Pathophysiological mechanisms involving aggressive islet cell destruction in fulminant type 1 diabetes [Review]

(2013) Shoichiro Tanaka et al.   ENDOCRINE JOURNAL

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children

(2013) Anette G. Ziegler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Infection of human islets of langerhans with two strains of coxsackie B virus serotype 1: Assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway

(2013) Mahesh Anagandula et al.   JOURNAL OF MEDICAL VIROLOGY

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Evidence of association between type 1 diabetes and exposure to enterovirus in Cuban children and adolescents

(2013) Luis Sarmiento et al.   MEDICC Review

Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses

(2013) Hyelim Cho et al.   NATURE MEDICINE

Cellular Self-Defense: How Cell-Autonomous Immunity Protects Against Pathogens

(2013) F. Randow et al.   SCIENCE

Innate antiviral signalling in the central nervous system

(2013) Michael Carty et al.   TRENDS IN IMMUNOLOGY

The Hygiene Hypothesis: An Explanation for the Increased Frequency of Insulin-Dependent Diabetes

(2013) J.-F. Bach et al.   Cold Spring Harbor Perspectives in Medicine

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

(2013) Tatiane C. Nogueira et al.   PLoS Genetics

The ‘Hygiene hypothesis’ and the sharp gradient in the incidence of autoimmune and allergic diseases between Russian Karelia and Finland

(2012) Anita Kondrashova et al.   APMIS

Prevention or acceleration of type 1 diabetes by viruses

(2012) Liana Ghazarian et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

(2012) R. Bergholdt et al.   DIABETES

Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1

(2012) S. J. Richardson et al.   DIABETOLOGIA

Mouse liver-specific CD8+ T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes

(2012) Sylvie Chabot et al.   JOURNAL OF AUTOIMMUNITY

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intrinsic antiviral immunity

(2012) Nan Yan et al.   NATURE IMMUNOLOGY

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis

(2012) I Santin et al.   Cell Death & Disease

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

An Interferon-Induced Helicase (IFIH1) Gene Polymorphism Associates With Different Rates of Progression From Autoimmunity to Type 1 Diabetes

(2011) C. Winkler et al.   DIABETES

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic  -Cell Apoptosis via Regulation of the BH3-Only Protein Bim

(2011) I. Santin et al.   DIABETES

Type 1 Diabetes and Interferon Therapy: A nationwide survey in Japan

(2011) K. Nakamura et al.   DIABETES CARE

Fulminant type 1 diabetes-an important subtype in East Asia

(2011) Akihisa Imagawa et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes

(2011) A. Willcox et al.   DIABETOLOGIA

A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes

(2011) Laura Espino-Paisan et al.   IMMUNOGENETICS

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

(2011) Esteban N. Gurzov et al.   TRENDS IN CELL BIOLOGY

Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci

(2011) Alexandra Zhernakova et al.   PLoS Genetics

Genetics of Type 1 Diabetes: What's Next?

(2010) F. Pociot et al.   DIABETES

Specific gene expression signature associated with development of autoimmune type-I diabetes using whole-blood microarray analysis

(2010) F Reynier et al.   GENES AND IMMUNITY

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells

(2010) S A Long et al.   GENES AND IMMUNITY

Etiology of Type 1 Diabetes

(2010) John A. Todd   IMMUNITY

Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases

(2010) Jin-Hui Tao et al.   MOLECULAR BIOLOGY REPORTS

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

(2010) Matthias Heinig et al.   NATURE

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host

(2010) Didier Hober et al.   Nature Reviews Endocrinology

Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes

(2010) Kate Downes et al.   PLoS One

Detection of Enterovirus RNA in Peripheral Blood Mononuclear Cells of Type 1 Diabetic Patients Beyond the Stage of Acute Infection

(2010) Barbara M. Schulte et al.   VIRAL IMMUNOLOGY

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic  -Cell Apoptosis

(2009) F. Moore et al.   DIABETES

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

(2009) M. Cnop et al.   DIABETOLOGIA

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA

(2009) Maikel L. Colli et al.   HUMAN MOLECULAR GENETICS

Antiviral effect of nicotinamide on enterovirus-infected human islets in vitro: Effect on virus replication and chemokine secretion

(2009) Annika Moëll et al.   JOURNAL OF MEDICAL VIROLOGY

Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study

(2009) Christopher C Patterson et al.   LANCET

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

(2009) Chris Wallace et al.   NATURE GENETICS

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Genetics of Type 1A Diabetes

(2009) Patrick Concannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

MDA5/RIG-I and virus recognition

(2008) Osamu Takeuchi et al.   CURRENT OPINION IN IMMUNOLOGY

Analysis of pancreas tissue in a child positive for islet cell antibodies

(2008) M. Oikarinen et al.   DIABETOLOGIA

Review series on helminths, immune modulation and the hygiene hypothesis: How might infection modulate the onset of type 1 diabetes?

(2008) Anne Cooke   IMMUNOLOGY

Selective inhibitors of picornavirus replication

(2008) Armando M. De Palma et al.   MEDICINAL RESEARCH REVIEWS

Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease

(2008) Deborah J. Smyth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Concordance for Islet Autoimmunity among Monozygotic Twins

(2008) Maria J. Redondo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interferon-  initiates type 1 diabetes in nonobese diabetic mice

(2008) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA