The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
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Title
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
Authors
Keywords
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Journal
NATURE GENETICS
Volume 51, Issue 11, Pages 1588-1595
Publisher
Springer Science and Business Media LLC
Online
2019-11-02
DOI
10.1038/s41588-019-0524-6
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Note: Only part of the references are listed.- Transcription factors and 3D genome conformation in cell-fate decisions
- (2019) Ralph Stadhouders et al. NATURE
- Long-range enhancer–promoter contacts in gene expression control
- (2019) Stefan Schoenfelder et al. NATURE REVIEWS GENETICS
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- (2019) Irene Miguel-Escalada et al. NATURE GENETICS
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- (2018) Kaur Alasoo et al. NATURE GENETICS
- GeNets: a unified web platform for network-based genomic analyses
- (2018) Taibo Li et al. NATURE METHODS
- Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors
- (2018) Sergio Gonzalez-Duque et al. Cell Metabolism
- DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway
- (2018) Reinaldo S. Dos Santos et al. DIABETOLOGIA
- Organizational principles of 3D genome architecture
- (2018) M. Jordan Rowley et al. NATURE REVIEWS GENETICS
- Static and Dynamic DNA Loops form AP-1-Bound Activation Hubs during Macrophage Development
- (2017) Douglas H. Phanstiel et al. MOLECULAR CELL
- Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
- (2017) Maxwell R Mumbach et al. NATURE GENETICS
- Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations
- (2017) Sarah Kim-Hellmuth et al. Nature Communications
- Variant Set Enrichment: an R package to identify disease-associated functional genomic regions
- (2017) Musaddeque Ahmed et al. BioData Mining
- The Pancreatic Islet Regulome Browser
- (2017) Loris Mularoni et al. Frontiers in Genetics
- Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations
- (2016) Phillippa C. Taberlay et al. GENOME RESEARCH
- UMI-4C for quantitative and targeted chromosomal contact profiling
- (2016) Omer Schwartzman et al. NATURE METHODS
- A scored human protein–protein interaction network to catalyze genomic interpretation
- (2016) Taibo Li et al. NATURE METHODS
- Analyzing and interpreting genome data at the network level with ConsensusPathDB
- (2016) Ralf Herwig et al. Nature Protocols
- Viral infections in type 1 diabetes mellitus — why the β cells?
- (2016) Anne Op de Beeck et al. Nature Reviews Endocrinology
- The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)
- (2016) Jacqueline MacArthur et al. NUCLEIC ACIDS RESEARCH
- Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences
- (2016) Sebastian Moran et al. Epigenomics
- Reorganization of chromosome architecture in replicative cellular senescence
- (2016) Steven W. Criscione et al. Science Advances
- MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses
- (2016) Ernesto S. Nakayasu et al. mSystems
- Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms
- (2015) Flora Brozzi et al. DIABETOLOGIA
- A global reference for human genetic variation
- (2015) Richard A. Gibbs et al. NATURE
- Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers
- (2015) Suna Onengut-Gumuscu et al. NATURE GENETICS
- Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls
- (2015) Mary D Fortune et al. NATURE GENETICS
- ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors
- (2015) Christian Schmidl et al. NATURE METHODS
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
- Global Reorganization of the Nuclear Landscape in Senescent Cells
- (2015) Tamir Chandra et al. Cell Reports
- HTSeq--a Python framework to work with high-throughput sequencing data
- (2014) S. Anders et al. BIOINFORMATICS
- Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
- (2014) Yonit Lavin et al. CELL
- Role of LDB1 in the transition from chromatin looping to transcription activation
- (2014) I. Krivega et al. GENES & DEVELOPMENT
- Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation
- (2014) François Le Dily et al. GENES & DEVELOPMENT
- Functional and topological characteristics of mammalian regulatory domains
- (2014) O. Symmons et al. GENOME RESEARCH
- Bayesian Proteoform Modeling Improves Protein Quantification of Global Proteomic Measurements
- (2014) Bobbie-Jo M. Webb-Robertson et al. MOLECULAR & CELLULAR PROTEOMICS
- DNase Footprint Signatures Are Dictated by Factor Dynamics and DNA Sequence
- (2014) Myong-Hee Sung et al. MOLECULAR CELL
- Genetic and epigenetic fine mapping of causal autoimmune disease variants
- (2014) Kyle Kai-How Farh et al. NATURE
- Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants
- (2014) Lorenzo Pasquali et al. NATURE GENETICS
- Comprehensive analysis of DNA methylation data with RnBeads
- (2014) Yassen Assenov et al. NATURE METHODS
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- (2013) Renato Ostuni et al. CELL
- Effect of natural genetic variation on enhancer selection and function
- (2013) S. Heinz et al. NATURE
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- (2013) Jason D Buenrostro et al. NATURE METHODS
- Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data
- (2013) Job Dekker et al. NATURE REVIEWS GENETICS
- Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
- (2013) S. C. J. Parker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GENCODE: The reference human genome annotation for The ENCODE Project
- (2012) J. Harrow et al. GENOME RESEARCH
- A Novel IL-10-Independent Regulatory Role for B Cells in Suppressing Autoimmunity by Maintenance of Regulatory T Cells via GITR Ligand
- (2012) A. Ray et al. JOURNAL OF IMMUNOLOGY
- Topological domains in mammalian genomes identified by analysis of chromatin interactions
- (2012) Jesse R. Dixon et al. NATURE
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- (2012) Elphège P. Nora et al. NATURE
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- The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
- (2012) Décio L. Eizirik et al. PLoS Genetics
- Molecular signatures database (MSigDB) 3.0
- (2011) A. Liberzon et al. BIOINFORMATICS
- Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene
- (2011) Lucy J. Davison et al. HUMAN MOLECULAR GENETICS
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- (2011) Philippe Ravassard et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2010) Raffaella Melzi et al. CELL TRANSPLANTATION
- Etiology of Type 1 Diabetes
- (2010) John A. Todd IMMUNITY
- Prediction and Pathogenesis in Type 1 Diabetes
- (2010) Anette-G. Ziegler et al. IMMUNITY
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
- (2010) Sven Heinz et al. MOLECULAR CELL
- TopHat: discovering splice junctions with RNA-Seq
- (2009) Cole Trapnell et al. BIOINFORMATICS
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA
- (2009) Maikel L. Colli et al. HUMAN MOLECULAR GENETICS
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- (2009) Vladislav A. Petyuk et al. MOLECULAR & CELLULAR PROTEOMICS
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- The role of inflammation in insulitis and β-cell loss in type 1 diabetes
- (2009) Décio L. Eizirik et al. Nature Reviews Endocrinology
- Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal
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- DeconMSn: a software tool for accurate parent ion monoisotopic mass determination for tandem mass spectra
- (2008) A. M. Mayampurath et al. BIOINFORMATICS
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