Klotho overexpression improves amyloid‐β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease

Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy

(2019) Natalia N. Nalivaeva et al.   BRITISH JOURNAL OF PHARMACOLOGY

Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice

(2019) Dongxue Li et al.   Frontiers in Cellular Neuroscience

Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS

(2019) Ella Zeldich et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Lentiviral vector–mediated overexpression of Klotho in the brain improves Alzheimer's disease–like pathology and cognitive deficits in mice

(2019) Chen-Ye Zeng et al.   NEUROBIOLOGY OF AGING

Folate receptor alpha-modified nanoparticles for the targeting of the central nervous system

(2019) Nataliya Kuplennik et al.   ACS Applied Materials & Interfaces

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways

(2019) Steven M. Greenberg et al.   Nature Reviews Neurology

Transplantation of in vitro cultured endothelial progenitor cells repairs the blood-brain barrier and improves cognitive function of APP/PS1 transgenic AD mice

(2018) Shishuang Zhang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Magnesium Reduces Blood-Brain Barrier Permeability and Regulates Amyloid-β Transcytosis

(2018) Donghui Zhu et al.   MOLECULAR NEUROBIOLOGY

Characterization of Impaired Cerebrovascular Structure in APP/PS1 Mouse Brains

(2018) Kee-Chan Ahn et al.   NEUROSCIENCE

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease: from Mechanisms to Therapy

(2018) Shu-Hui Xin et al.   NEUROTOXICITY RESEARCH

Klotho controls the brain–immune system interface in the choroid plexus

(2018) Lei Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The anti-aging protein klotho alleviates injury of nigrostriatal dopaminergic pathway in 6-hydroxydopamine rat model of Parkinson's disease: Involvement of PKA/CaMKII/CREB signaling

(2017) Tourandokht Baluchnejadmojarad et al.   EXPERIMENTAL GERONTOLOGY

NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

(2017) Jun Yin et al.   MOLECULAR NEUROBIOLOGY

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

(2017) Jun Wang et al.   Nature Reviews Neurology

Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease

(2017) Xi Kuang et al.   Frontiers in Aging Neuroscience

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1–40 brain-to-blood efflux and peripheral uptake transport

(2016) Y.-X. Guo et al.   NEUROSCIENCE

Role of RAGE in Alzheimer’s Disease

(2015) Zhiyou Cai et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Molecular Basis of Klotho: From Gene to Function in Aging

(2015) Yuechi Xu et al.   ENDOCRINE REVIEWS

α-Klotho Expression in Human Tissues

(2015) Kenneth Lim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

(2015) D. B. Dubal et al.   JOURNAL OF NEUROSCIENCE

P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observations

(2015) Catherine Chiu et al.   NEUROBIOLOGY OF AGING

Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression

(2015) Anna Massó et al.   PLoS One

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Life Extension Factor Klotho Enhances Cognition

(2014) Dena B. Dubal et al.   Cell Reports

Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease

(2013) Henna Martiskainen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease

(2013) Richard D. Semba et al.   NEUROSCIENCE LETTERS

The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease

(2013) Ayman ElAli et al.   Frontiers in Physiology

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Reduced CSF turnover and decreased ventricular Aβ42 levels are related

(2011) Jean-Marie Serot et al.   BMC NEUROSCIENCE

Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-β

(2009) Ryusuke Takechi et al.   BRITISH JOURNAL OF NUTRITION

Amyloid Deposition and Influx Transporter Expression at the Blood-Brain Barrier Increase in Normal Aging

(2009) Gerald D. Silverberg et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY