Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways

Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease

(2019) Feng Xiong et al.   Alzheimers & Dementia

Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura

(2019) Gargi Banerjee et al.   ANNALS OF NEUROLOGY

Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain

(2019) Roxana Aldea et al.   Frontiers in Aging Neuroscience

Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy

(2019) Yoshinori Endo et al.   Acta Neuropathologica Communications

Immunotherapy with ponezumab for probable cerebral amyloid angiopathy

(2019) Claire Leurent et al.   Annals of Clinical and Translational Neurology

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy

(2019) Jessica Camacho et al.   Frontiers in Neurology

Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity

(2019) Sandro Marini et al.   JAMA Neurology

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

(2019) Jerrah K. Holth et al.   SCIENCE

Microbleeds colocalize with enlarged juxtacortical perivascular spaces in amnestic mild cognitive impairment and early Alzheimer’s disease: A 7 Tesla MRI study

(2019) Willem H Bouvy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Insights into the pathogenesis of normal-pressure hydrocephalus

(2019) Salvatore Spina et al.   NEUROLOGY

Different microvascular alterations underlie microbleeds and microinfarcts

(2019) Susanne J. Veluw et al.   ANNALS OF NEUROLOGY

Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain

(2019) Susanne J. van Veluw et al.   NEURON

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

(2018) Nazira J. Albargothy et al.   ACTA NEUROPATHOLOGICA

Person-specific contribution of neuropathologies to cognitive loss in old age

(2018) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

(2018) Benjamin A. Plog et al.   Annual Review of Pathology-Mechanisms of Disease

The “glymphatic” mechanism for solute clearance in Alzheimer’s disease: game changer or unproven speculation?

(2018) Alex J. Smith et al.   FASEB JOURNAL

The Glymphatic System and Waste Clearance with Brain Aging: A Review

(2018) Helene Benveniste et al.   GERONTOLOGY

Biomarker pattern of ARIA-E participants in phase 3 randomized clinical trials with bapineuzumab

(2018) Enchi Liu et al.   NEUROLOGY

ABBY

(2018) Jeffrey L. Cummings et al.   NEUROLOGY

Ultra-Slow Single-Vessel BOLD and CBV-Based fMRI Spatiotemporal Dynamics and Their Correlation with Neuronal Intracellular Calcium Signals

(2018) Yi He et al.   NEURON

β-Amyloid accumulation in the human brain after one night of sleep deprivation

(2018) Ehsan Shokri-Kojori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diagnosis of Cerebral Amyloid Angiopathy

(2018) Steven M. Greenberg et al.   STROKE

Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

(2018) David C. Hondius et al.   Acta Neuropathologica Communications

Cerebrovascular Alterations in Alzheimer Disease

(2018) Costantino Iadecola et al.   CIRCULATION RESEARCH

Clusterin contributes to early stage of Alzheimer's disease pathogenesis

(2018) Shin-Bi Oh et al.   BRAIN PATHOLOGY

Clinical Evaluation of Amyloid-Related Imaging Abnormalities in Bapineuzumab Phase III Studies

(2018) H. Robert Brashear et al.   JOURNAL OF ALZHEIMERS DISEASE

Higher Pulsatility in Cerebral Perforating Arteries in Patients With Small Vessel Disease Related Stroke, a 7T MRI Study

(2018) Lennart J. Geurts et al.   STROKE

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

(2018) Humberto Mestre et al.   Nature Communications

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

(2018) Humberto Mestre et al.   eLife

Central Review of Amyloid-Related Imaging Abnormalities in Two Phase III Clinical Trials of Bapineuzumab in Mild-To-Moderate Alzheimer’s Disease Patients

(2017) Nzeera Ketter et al.   JOURNAL OF ALZHEIMERS DISEASE

Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow

(2017) Beatrice Bedussi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Apolipoprotein E and Alzheimer’s disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins

(2017) Tien-Phat V. Huynh et al.   JOURNAL OF LIPID RESEARCH

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

(2017) Minghuan Wang et al.   JOURNAL OF NEUROSCIENCE

Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET

(2017) Mony J. de Leon et al.   JOURNAL OF NUCLEAR MEDICINE

Cerebrovascular function in presymptomatic and symptomatic individuals with hereditary cerebral amyloid angiopathy: a case-control study

(2017) Anna M van Opstal et al.   LANCET NEUROLOGY

Detection, risk factors, and functional consequences of cerebral microinfarcts

(2017) Susanne J van Veluw et al.   LANCET NEUROLOGY

MRI-visible perivascular spaces in cerebral amyloid angiopathy and hypertensive arteriopathy

(2017) Andreas Charidimou et al.   NEUROLOGY

Entrainment of Arteriole Vasomotor Fluctuations by Neural Activity Is a Basis of Blood-Oxygenation-Level-Dependent “Resting-State” Connectivity

(2017) Celine Mateo et al.   NEURON

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

(2017) Aleksandra M. Wojtas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease

(2017) Susanne Ostrowitzki et al.   Alzheimers Research & Therapy

Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort

(2017) Rebecca F. Gottesman et al.   JAMA Neurology

Arterial Pulsations cannot Drive Intramural Periarterial Drainage: Significance for Aβ Drainage

(2017) Alexandra K. Diem et al.   Frontiers in Neuroscience

Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry

(2017) Nobuto Kakuda et al.   Acta Neuropathologica Communications

Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome

(2016) Donna M. Wilcock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy

(2016) Abby Keable et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ

(2016) J. Scott Miners et al.   BRAIN PATHOLOGY

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases

(2016) Erik N. T. P. Bakker et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline

(2016) Roderick A. Corriveau et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions

(2016) Victor L Villemagne et al.   CURRENT OPINION IN NEUROBIOLOGY

Monitoring Blood-Brain Barrier Integrity Following Amyloid-β Immunotherapy Using Gadolinium-Enhanced MRI in a PDAPP Mouse Model

(2016) Ines Blockx et al.   JOURNAL OF ALZHEIMERS DISEASE

Safety and Efficacy of Anti-Amyloid-β Immunotherapy in Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2016) Ross Penninkilampi et al.   Journal of Neuroimmune Pharmacology

Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study

(2016) Panagiotis Fotiadis et al.   LANCET NEUROLOGY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Systems proteomic analysis reveals that clusterin and tissue inhibitor of metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy

(2016) A. Manousopoulou et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Incidence of Dementia over Three Decades in the Framingham Heart Study

(2016) Claudia L. Satizabal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

(2016) Mark Ultsch et al.   Scientific Reports

Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces

(2015) Susanne J van Veluw et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

(2015) Zhiqiang Xu et al.   Molecular Neurodegeneration

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

(2015) Zane Jaunmuktane et al.   NATURE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Cerebral amyloid angiopathy and its co-occurrence with Alzheimer's disease and other cerebrovascular neuropathologic changes

(2015) Willa D. Brenowitz et al.   NEUROBIOLOGY OF AGING

Matrix metalloproteinase 9–mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy

(2015) Lingzhi Zhao et al.   NEUROBIOLOGY OF AGING

Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease

(2015) Natalie S. Ryan et al.   NEUROBIOLOGY OF AGING

Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons

(2015) Patricia A. Boyle et al.   NEUROLOGY

Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models

(2015) Fan Liao et al.   Acta Neuropathologica Communications

Aβ immunotherapy for Alzheimer’s disease: effects on apoE and cerebral vasculopathy

(2014) Kenji Sakai et al.   ACTA NEUROPATHOLOGICA

Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage

(2014) Daniel Woo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Structural network alterations and neurological dysfunction in cerebral amyloid angiopathy

(2014) Y. D. Reijmer et al.   BRAIN

APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis

(2014) Y. Liu et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Outcome markers for clinical trials in cerebral amyloid angiopathy

(2014) Steven M Greenberg et al.   LANCET NEUROLOGY

Spontaneous amyloid-related imaging abnormalities in a cognitively normal adult

(2014) M. R. Raman et al.   NEUROLOGY

Cortical thickness mediates the effect of  -amyloid on episodic memory

(2014) S. Villeneuve et al.   NEUROLOGY

Incidence of cerebral microbleeds in preclinical Alzheimer disease

(2014) P. A. Yates et al.   NEUROLOGY

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias

(2014) Gary W. Beecham et al.   PLoS Genetics

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

(2013) Michal Arbel-Ornath et al.   ACTA NEUROPATHOLOGICA

Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain

(2013) Cheryl A. Hawkes et al.   AGING CELL

Vascular alterations in PDAPP mice after anti-Aβ immunotherapy: Implications for amyloid-related imaging abnormalities

(2013) Wagner Zago et al.   Alzheimers & Dementia

Anti-amyloid β autoantibodies in cerebral amyloid angiopathy-related inflammation: Implications for amyloid-modifying therapies

(2013) Fabrizio Piazza et al.   ANNALS OF NEUROLOGY

Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles

(2013) C. H. Andrade-Moraes et al.   BRAIN

The APOE ε4/ε4 Genotype Potentiates Vascular Fibrin(Ogen) Deposition in Amyloid-Laden Vessels in the Brains of Alzheimer's Disease Patients

(2013) Karin Hultman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging

(2013) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Neurovascular decoupling is associated with severity of cerebral amyloid angiopathy

(2013) S. Peca et al.   NEUROLOGY

Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy

(2013) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Garbage Truck of the Brain

(2013) M. Nedergaard   SCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Functional magnetic resonance imaging detection of vascular reactivity in cerebral amyloid angiopathy

(2012) Andrew Dumas et al.   ANNALS OF NEUROLOGY

A Shift in Microglial β-Amyloid Binding in Alzheimer's Disease Is Associated with Cerebral Amyloid Angiopathy

(2012) Matthew Zabel et al.   BRAIN PATHOLOGY

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis

(2012) Reisa Sperling et al.   LANCET NEUROLOGY

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Cerebrovascular lesions induce transient  -amyloid deposition

(2011) M. Garcia-Alloza et al.   BRAIN

Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy

(2011) Byung Han et al.   Molecular Neurodegeneration

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide

(2011) Priyanka Narayan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neuropathology after active Aβ42 immunotherapy: implications for Alzheimer’s disease pathogenesis

(2010) Delphine Boche et al.   ACTA NEUROPATHOLOGICA

Capillary cerebral amyloid angiopathy identifies a distinct APOE ε4-associated subtype of sporadic Alzheimer’s disease

(2010) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Cerebral amyloid angiopathy pathology and cognitive domains in older persons

(2010) Zoe Arvanitakis et al.   ANNALS OF NEUROLOGY

Hereditary Cerebral Hemorrhage With Amyloidosis Associated With the E693K Mutation of APP

(2010) Orso Bugiani et al.   ARCHIVES OF NEUROLOGY

Incidence of cerebral microbleeds: A longitudinal study in a memory clinic population

(2010) J. D. C. Goos et al.   NEUROLOGY

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

(2010) Marta Cortes-Canteli et al.   NEURON

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-β variants in cells composing the cerebral vessel walls

(2009) S. Fossati et al.   FASEB JOURNAL

Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

(2009) D.M. Wilcock et al.   NEUROSCIENCE

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

Patients With Alzheimer Disease With Multiple Microbleeds

(2009) Jeroen D.C. Goos et al.   STROKE

Lymphatic drainage of the brain and the pathophysiology of neurological disease

(2008) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Clinical and Neuropathological Features of the Arctic APP Gene Mutation Causing Early-Onset Alzheimer Disease

(2008) Hans Basun et al.   ARCHIVES OF NEUROLOGY

Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain

(2008) D. Boche et al.   BRAIN

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Charge Alterations of E22 Enhance the Pathogenic Properties of the Amyloid β-Protein

(2003) Jerry P. Melchor et al.   JOURNAL OF NEUROCHEMISTRY