Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression
Published 2015 View Full Article
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Title
Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression
Authors
Keywords
Alzheimers disease, Hippocampus, Aging, Cerebellum, Kidneys, Prefrontal cortex, Central nervous system, Alternative splicing
Journal
PLoS One
Volume 10, Issue 11, Pages e0143623
Publisher
Public Library of Science (PLoS)
Online
2015-11-25
DOI
10.1371/journal.pone.0143623
References
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Note: Only part of the references are listed.- Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice
- (2015) D. B. Dubal et al. JOURNAL OF NEUROSCIENCE
- Identification of Cleavage Sites Leading to the Shed Form of the Anti-Aging Protein Klotho
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- Life Extension Factor Klotho Enhances Cognition
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- (2013) Michael Phelps et al. BIOGERONTOLOGY
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- (2013) Sarah M. Clinton et al. BRAIN RESEARCH
- The Antiaging Protein Klotho Enhances Oligodendrocyte Maturation and Myelination of the CNS
- (2013) C.-D. Chen et al. JOURNAL OF NEUROSCIENCE
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- (2013) Xi Kuang et al. NEUROBIOLOGY OF AGING
- Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease
- (2013) Richard D. Semba et al. NEUROSCIENCE LETTERS
- Association of Klotho Polymorphisms with Healthy Aging: A Systematic Review and Meta-Analysis
- (2013) Danilo Di Bona et al. REJUVENATION RESEARCH
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- (2012) Dwight C. German et al. NEUROBIOLOGY OF AGING
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- (2012) Tetsu Akimoto et al. BMC Nephrology
- Promoter methylation and age-related downregulation of Klotho in rhesus monkey
- (2011) Gwendalyn D. King et al. AGE
- Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells
- (2011) Ryan E. Forster et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposure
- (2011) Arifumi Kosakai et al. BRAIN RESEARCH
- Exercise-Induced Cognitive Plasticity, Implications for Mild Cognitive Impairment and Alzheimer’s Disease
- (2011) Philip P. Foster et al. Frontiers in Neurology
- Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
- (2010) H. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Klotho is a substrate for α-, β- and γ-secretase
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- (2008) John Papaconstantinou MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice
- (2008) M. Shiozaki et al. NEUROSCIENCE
- Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey
- (2007) James A. Duce et al. GLIA
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