The role of MDM2–p53 axis dysfunction in the hepatocellular carcinoma transformation

Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53

(2019) Yann Breton et al.   JOURNAL OF VIROLOGY

CD36 mediates palmitate acid-induced metastasis of gastric cancer via AKT/GSK-3β/β-catenin pathway

(2019) Jiaomeng Pan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Age independent survival benefit for patients with hepatocellular carcinoma (HCC) without metastases at diagnosis: a population-based study

(2019) Enrico N De Toni et al.   GUT

CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4+ T-Cell–Dependent Control of Senescence

(2019) Jana C. Mossanen et al.   GASTROENTEROLOGY

Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation

(2019) Jinchul Kim et al.   CANCER CELL

Risk Factors for Severe Liver Disease in Patients With Type 2 Diabetes

(2019) Karl Björkström et al.   Clinical Gastroenterology and Hepatology

Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of HCV-infected Cells and Liver to Identify Pathways Associated With Disease Development

(2019) Joachim Lupberger et al.   GASTROENTEROLOGY

Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity

(2019) Muhammad waseem Khan et al.   International Journal of Nanomedicine

miR‐146a‐5p Enhances Hepatitis B Virus Replication Through Autophagy to Promote Aggravation of Chronic Hepatitis B

(2019) Lei Fu et al.   IUBMB LIFE

From NASH to HCC: current concepts and future challenges

(2019) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

MiR-34a overexpression enhances the inhibitory effect of doxorubicin on HepG2 cells

(2019) Shun-Zhen Zheng et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A Novel Indolizine Derivative Induces Apoptosis Through the Mitochondria p53 Pathway in HepG2 Cells

(2019) Yushuang Liu et al.   Frontiers in Pharmacology

Repression of Death Receptor–Mediated Apoptosis of Hepatocytes by Hepatitis B Virus e Antigen

(2019) Wei Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

MDM2-NFAT1 dual inhibitor, MA242: Effective against hepatocellular carcinoma, independent of p53

(2019) Wei Wang et al.   CANCER LETTERS

Lgr5+ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis

(2019) Chow Hiang Ang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53

(2019) Edmund Osei Kuffour et al.   mBio

Hepatitis C Virus Structure: Defined by What It Is Not

(2019) Altaira D. Dearborn et al.   Cold Spring Harbor Perspectives in Medicine

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma

(2019) Sara Gomes et al.   Cancers

Targeting p53/TRAIL/caspase-8 signaling by adiponectin reverses thioacetamide-induced hepatocellular carcinoma in rats

(2019) Entsar A. Nazmy et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

HIV RNA, CD4+ Percentage, and Risk of Hepatocellular Carcinoma by Cirrhosis Status

(2019) Jessie Torgersen et al.   JNCI-Journal of the National Cancer Institute

Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation

(2019) Ming Hong et al.   Cells

Disease Severity Is Associated With Higher Healthcare Utilization in Nonalcoholic Steatohepatitis Medicare Patients

(2019) Stuart Gordon et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Loss of RDM1 enhances hepatocellular carcinoma progression via p53 and Ras/Raf/ERK pathways

(2019) Shi‐Lu Chen et al.   Molecular Oncology

Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

(2019) Na Kong et al.   Science Translational Medicine

Abnormal Expression of ERα in Cholangiocytes of Patients With Primary Biliary Cholangitis Mediated Intrahepatic Bile Duct Inflammation

(2019) Hui Cao et al.   Frontiers in Immunology

Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose

(2018) Prachi Borude et al.   AMERICAN JOURNAL OF PATHOLOGY

Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

(2018) Debanjan Dhar et al.   CANCER CELL

Reviewing the future of the P53 field

(2018) Arnold J Levine   CELL DEATH AND DIFFERENTIATION

Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1

(2018) Ling Fang et al.   CELL DEATH AND DIFFERENTIATION

KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration

(2018) Shan Wang et al.   CELL RESEARCH

Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma

(2018) Omar Massoud et al.   Clinics in Liver Disease

Germline Duplication of SNORA18L5 Increases Risk for HBV-related Hepatocellular Carcinoma by Altering Localization of Ribosomal Proteins and Decreasing Levels of p53

(2018) Pengbo Cao et al.   GASTROENTEROLOGY

Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α

(2018) Subhasree Basu et al.   GENES & DEVELOPMENT

Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis

(2018) Chen Qu et al.   HEPATOLOGY

Extrahepatic cancers are the leading cause of death in patients achieving hepatitis B virus control or hepatitis C virus eradication

(2018) Manon Allaire et al.   HEPATOLOGY

Sirt1 alleviates LPS induced inflammation of periodontal ligament fibroblasts via downregulation of TLR4

(2018) Kexin Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development

(2018) Xingwang Xie et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells

(2018) Shu-Guang Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

(2018) Peter R. Galle et al.   JOURNAL OF HEPATOLOGY

Melatonin modulates dysregulated circadian clocks in mice with diethylnitrosamine-induced hepatocellular carcinoma

(2018) Diana I. Sánchez et al.   JOURNAL OF PINEAL RESEARCH

Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury

(2018) Shengda Lin et al.   NATURE

Hepatitis B virus X protein represses LKB1 expression to promote tumor progression and poor postoperative outcome in hepatocellular carcinoma

(2018) Cheng-Chung Wu et al.   SURGERY

Inhibition of HIV early replication by the p53 and its downstream gene p21

(2018) Binshan Shi et al.   Virology Journal

Δ133p53α, a natural p53 isoform, contributes to conditional reprogramming and long-term proliferation of primary epithelial cells

(2018) Abdul M. Mondal et al.   Cell Death & Disease

Role of HBx in hepatitis B virus persistence and its therapeutic implications

(2018) Betty L Slagle et al.   Current Opinion in Virology

Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers

(2018) Maria Lina Tornesello et al.   Cancers

Sparstolonin B (SSnB) attenuates liver fibrosisvia a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent

(2018) Diptadip Dattaroy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hepatitis C virus manipulates humans as its favorite host for long term relationship

(2018) Ratna B. Ray et al.   HEPATOLOGY

RBM38 plays a tumor-suppressor role via stabilizing the p53-mdm2 loop function in hepatocellular carcinoma

(2018) Jiazhou Ye et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Troxerutin subdues hepatic tumorigenesis via disrupting the MDM2–p53 interaction

(2018) Nisha Susan Thomas et al.   Food & Function

Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a "dominant-positive" mechanism

(2018) Dawid Walerych et al.   Oncotarget

A GYS2/p53 negative feedback loop restricts tumor growth in HBV-related hepatocellular carcinoma

(2018) Shi-Lu Chen et al.   CANCER RESEARCH

Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy

(2018) Giuseppe Lonetto et al.   CELL DEATH AND DIFFERENTIATION

p53 as a double-edged sword in the progression of non-alcoholic fatty liver disease

(2018) Zhibin Yan et al.   LIFE SCIENCES

Evolution of efficacious pangenotypic hepatitis C virus therapies

(2018) Muhammad Usman Ashraf et al.   MEDICINAL RESEARCH REVIEWS

MicroRNA-621 Acts as a Tumor Radiosensitizer by Directly Targeting SETDB1 in Hepatocellular Carcinoma

(2018) Yingjie Shao et al.   MOLECULAR THERAPY

Forcing ATGL expression in hepatocarcinoma cells imposes glycolytic rewiring through PPAR-α/p300-mediated acetylation of p53

(2018) Luca Di Leo et al.   ONCOGENE

Estrogen Signals Through Peroxisome Proliferator-Activated Receptor−γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease

(2017) Aurèle Besse-Patin et al.   GASTROENTEROLOGY

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

(2017) Daniela Sia et al.   GASTROENTEROLOGY

Hepatitis B virus X protein activates E3 ubiquitin ligase Siah-1 to control virus propagation via a negative feedback loop

(2017) Sujeong Yeom et al.   JOURNAL OF GENERAL VIROLOGY

Human germline hedgehog pathway mutations predispose to fatty liver

(2017) Maria J. Guillen-Sacoto et al.   JOURNAL OF HEPATOLOGY

Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification

(2017) Julien Calderaro et al.   JOURNAL OF HEPATOLOGY

CD44 is a key player in non-alcoholic steatohepatitis

(2017) Stéphanie Patouraux et al.   JOURNAL OF HEPATOLOGY

Hederagenin Supplementation Alleviates the Pro-Inflammatory and Apoptotic Response to Alcohol in Rats

(2017) Gyeong-Ji Kim et al.   Nutrients

Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture

(2017) Yucel Aydin et al.   Scientific Reports

Sensitization of cancer cells to cyclophosphamide therapy by an organoselenium compound through ROS-mediated apoptosis

(2016) Pramita Chakraborty et al.   BIOMEDICINE & PHARMACOTHERAPY

Causation by Diesel Exhaust Particles of Endothelial Dysfunctions in Cytotoxicity, Pro-inflammation, Permeability, and Apoptosis Induced by ROS Generation

(2016) Chia-Yi Tseng et al.   Cardiovascular Toxicology

HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant

(2016) William S. Mason et al.   GASTROENTEROLOGY

Hepatitis B e antigen and its precursors promote the progress of hepatocellular carcinoma by interacting with NUMB and decreasing p53 activity

(2016) Dan Liu et al.   HEPATOLOGY

IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice

(2016) Juri Bergmann et al.   HEPATOLOGY

TERTpromoter mutations and chromosome 8p loss are characteristic of nonalcoholic fatty liver disease-related hepatocellular carcinoma

(2016) Soo Ki Kim et al.   INTERNATIONAL JOURNAL OF CANCER

Mechanisms of HBV-induced hepatocellular carcinoma

(2016) Massimo Levrero et al.   JOURNAL OF HEPATOLOGY

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage

(2016) Angela Rizzo et al.   NUCLEIC ACIDS RESEARCH

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction

(2016) Che-Pei Kung et al.   Cell Reports

Sorafenib inhibits proliferation and invasion of human hepatocellular carcinoma cells via up-regulation of p53 and suppressing FoxM1

(2015) Ji-chao Wei et al.   ACTA PHARMACOLOGICA SINICA

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

(2015) Joan Font-Burgada et al.   CELL

The BCL-2 protein family, BH3-mimetics and cancer therapy

(2015) A R D Delbridge et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway

(2015) Heng Wu et al.   GUT

Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis

(2015) Ranxu Zhu et al.   JOURNAL OF PATHOLOGY

FUSE Binding Protein 1 Facilitates Persistent Hepatitis C Virus Replication in Hepatoma Cells by Regulating Tumor Suppressor p53

(2015) Updesh Dixit et al.   JOURNAL OF VIROLOGY

An mTORC1-Mdm2-Drosha Axis for miRNA Biogenesis in Response to Glucose- and Amino Acid-Deprivation

(2015) Peiying Ye et al.   MOLECULAR CELL

Hepatic progenitor cells of biliary origin with liver repopulation capacity

(2015) Wei-Yu Lu et al.   NATURE CELL BIOLOGY

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MDM2-p53 Pathway in Hepatocellular Carcinoma

(2014) X. Meng et al.   CANCER RESEARCH

Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice

(2014) Wei Wang et al.   GASTROENTEROLOGY

Integration of tumour and viral genomic characterisations in HBV-related hepatocellular carcinomas

(2014) Giuliana Amaddeo et al.   GUT

Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer

(2014) Krasimira Aleksandrova et al.   HEPATOLOGY

Elevated p53 promotes the processing of miR-18a to decrease estrogen receptor-α in female hepatocellular carcinoma

(2014) Chiao-Ling Li et al.   INTERNATIONAL JOURNAL OF CANCER

Hepatitis C virus core protein overcomes H2O2-induced apoptosis by downregulating p14 expression via DNA methylation

(2014) Y. L. Seo et al.   JOURNAL OF GENERAL VIROLOGY

CD147 promotes reprogramming of glucose metabolism and cell proliferation in HCC cells by inhibiting the p53-dependent signaling pathway

(2014) Qichao Huang et al.   JOURNAL OF HEPATOLOGY

Hepatitis C virus and metabolic disorder interactions towards liver damage and atherosclerosis

(2014) Umberto Vespasiani-Gentilucci   WORLD JOURNAL OF GASTROENTEROLOGY

Zonation of glucose and fatty acid metabolism in the liver: Mechanism and metabolic consequences

(2013) Brenda S. Hijmans et al.   BIOCHIMIE

Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling

(2013) Guobin He et al.   CELL

Non-Cell-Autonomous Tumor Suppression by p53

(2013) Amaia Lujambio et al.   CELL

Metabolic Regulation by p53 Family Members

(2013) Celia R. Berkers et al.   Cell Metabolism

HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration

(2013) Arik Cooper et al.   NATURE

Molecular mechanisms underlying RB protein function

(2013) Frederick A. Dick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation

(2012) Yuan-Yuan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

N-Acetylglucosaminyltransferase V regulates TGF-β response in hepatic stellate cells and the progression of steatohepatitis

(2012) Yoshihiro Kamada et al.   GLYCOBIOLOGY

The prevalence of cirrhosis and hepatocellular carcinoma in patients with human immunodeficiency virus infection

(2012) George N. Ioannou et al.   HEPATOLOGY

Expression profiling of selected genes of toxication and detoxication pathways in peripheral blood lymphocytes as a biomarker for predicting toxicity of environmental chemicals

(2012) Amit Sharma et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease

(2012) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

(2012) Rui E. Castro et al.   JOURNAL OF HEPATOLOGY

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

(2012) Wing-Kin Sung et al.   NATURE GENETICS

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration

(2012) M. K. Diril et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Therapeutic Effect and Biological Monitoring of p53 Gene in Advanced Hepatocellular Carcinoma

(2011) Shixi Chen et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Carcinogen-induced hepatic tumors in KLF6+/− mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation

(2011) Mirko Tarocchi et al.   HEPATOLOGY

p53gene therapy in combination with transcatheter arterial chemoembolization for HCC: One-year follow-up

(2011) Yong-Song Guan   WORLD JOURNAL OF GASTROENTEROLOGY

Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53

(2010) Joana D. Amaral et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis

(2010) Nuria Martínez-López et al.   HEPATOLOGY

Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease

(2010) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

OVEREXPRESSION OF ALDEHYDE DEHYDROGENASE-2 ATTENUATES CHRONIC ALCOHOL EXPOSURE-INDUCED APOPTOSIS, CHANGE IN Akt AND Pim SIGNALLING IN LIVER

(2009) Rui Guo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Clinical study of recombinant adenovirus-p53 combined with fractionated stereotactic radiotherapy for hepatocellular carcinoma

(2009) Zhi-xiang Yang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression

(2009) Geoffrey C Farrell et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

p53 Promotes proteasome-dependent degradation of oncogenic protein HBx by transcription of MDM2

(2009) Lingling Xian et al.   MOLECULAR BIOLOGY REPORTS

p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis

(2009) Joana D. Amaral et al.   TRENDS IN MOLECULAR MEDICINE

COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis

(2008) Alfred S.L. Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity

(2008) Sonja Wolff et al.   CELL RESEARCH

Llama-derived single-domain intrabodies inhibit secretion of hepatitis B virions in mice

(2008) Benedikte Serruys et al.   HEPATOLOGY

Cellular DNA repair cofactors affecting hepatitis B virus infection and replication

(2008) Fan Zhao et al.   WORLD JOURNAL OF GASTROENTEROLOGY