Molecular mechanisms underlying RB protein function

Structural Insights into the Mechanism of Phosphoregulation of the Retinoblastoma Protein

(2013) Ekaterina P. Lamber et al.   PLoS One

Identification and Characterization of Small Molecule Antagonists of pRb Inactivation by Viral Oncoproteins

(2012) Daniela Fera et al.   CHEMISTRY & BIOLOGY

Checkpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells

(2012) Lilian Kabeche et al.   CURRENT BIOLOGY

PP1 and PP2A phosphatases - cooperating partners in modulating retinoblastoma protein activation

(2012) Victoria Kolupaeva et al.   FEBS Journal

The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression

(2012) S. Sadasivam et al.   GENES & DEVELOPMENT

Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control

(2012) J. R. Burke et al.   GENES & DEVELOPMENT

Diversity within the pRb pathway: is there a code of conduct?

(2012) S Munro et al.   ONCOGENE

Deciphering the retinoblastoma protein phosphorylation code

(2012) Seth M. Rubin   TRENDS IN BIOCHEMICAL SCIENCES

The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle

(2012) Shauna A Henley et al.   Cell Division

The biochemical basis of CDK phosphorylation-independent regulation of E2F1 by the retinoblastoma protein

(2011) Matthew J. Cecchini et al.   BIOCHEMICAL JOURNAL

Mad2 Is a Critical Mediator of the Chromosome Instability Observed upon Rb and p53 Pathway Inhibition

(2011) Juan-Manuel Schvartzman et al.   CANCER CELL

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

(2011) L. Litovchick et al.   GENES & DEVELOPMENT

DNA Damage Signals through Differentially Modified E2F1 Molecules To Induce Apoptosis

(2011) J. Carnevale et al.   MOLECULAR AND CELLULAR BIOLOGY

RB Restricts DNA Damage-Initiated Tumorigenesis through an LXCXE-Dependent Mechanism of Transcriptional Control

(2011) Ryan J. Bourgo et al.   MOLECULAR CELL

Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

(2010) Agustin Chicas et al.   CANCER CELL

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein

(2010) Simon M Carr et al.   EMBO JOURNAL

Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive

(2010) C. H. Coschi et al.   GENES & DEVELOPMENT

Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling

(2010) T. van Harn et al.   GENES & DEVELOPMENT

Loss of pRB causes centromere dysfunction and chromosomal instability

(2010) A. L. Manning et al.   GENES & DEVELOPMENT

Methylation of the Retinoblastoma Tumor Suppressor by SMYD2

(2010) Louis A. Saddic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation-induced Conformational Changes in the Retinoblastoma Protein Inhibit E2F Transactivation Domain Binding

(2010) Jason R. Burke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein

(2010) Alexander Hirschi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lysine methylation regulates the pRb tumour suppressor protein

(2010) S Munro et al.   ONCOGENE

Proapoptotic Function of the Retinoblastoma Tumor Suppressor Protein

(2009) Alessandra Ianari et al.   CANCER CELL

A G1 Checkpoint Mediated by the Retinoblastoma Protein That Is Dispensable in Terminal Differentiation but Essential for Senescence

(2009) S. Talluri et al.   MOLECULAR AND CELLULAR BIOLOGY

Cdh1 Regulates Cell Cycle through Modulating the Claspin/Chk1 and the Rb/E2F1 Pathways

(2009) Daming Gao et al.   MOLECULAR BIOLOGY OF THE CELL

Division and apoptosis of E2f-deficient retinal progenitors

(2009) Danian Chen et al.   NATURE

E2f1–3 switch from activators in progenitor cells to repressors in differentiating cells

(2009) Jean-Leon Chong et al.   NATURE

Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/− mice

(2009) Hongbo Wang et al.   NATURE GENETICS

An E2F1-Dependent Gene Expression Program that Determines the Balance between Proliferation and Cell Death

(2008) Timothy C. Hallstrom et al.   CANCER CELL

RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3

(2008) M. S. Longworth et al.   GENES & DEVELOPMENT

pRB-E2F1 Complexes Are Resistant to Adenovirus E1A-Mediated Disruption

(2008) L. A. Seifried et al.   JOURNAL OF VIROLOGY

Conserved functions of the pRB and E2F families

(2008) Sander van den Heuvel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY