C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells

Triptolide inhibits viability and induces apoptosis in liver cancer cells through activation of the tumor suppressor gene p53

(2017) Yan-Yan Sun et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Triptolide inhibits tumor growth by induction of cellular senescence

(2016) Ruidong Li et al.   ONCOLOGY REPORTS

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Microarray Analysis of Colorectal Cancer Stromal Tissue Reveals Upregulation of Two Oncogenic miRNA Clusters

(2012) N. Nishida et al.   CLINICAL CANCER RESEARCH

Circulating MicroRNA in Digestive Tract Cancers

(2012) Daisuke Ichikawa et al.   GASTROENTEROLOGY

MicroRNAs in Liver Disease

(2012) Xin Wei Wang et al.   GASTROENTEROLOGY

Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

(2012) Zhao-Li Zhou et al.   NATURAL PRODUCT REPORTS

Triptolide and its expanding multiple pharmacological functions

(2011) Qiuyan Liu   INTERNATIONAL IMMUNOPHARMACOLOGY

XPB, a subunit of TFIIH, is a target of the natural product triptolide

(2011) Denis V Titov et al.   Nature Chemical Biology

Effects of triptolide on RIZ1 expression, proliferation and apoptosis in multiple myeloma U266 cells

(2010) Fei Zhao et al.   ACTA PHARMACOLOGICA SINICA

Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide

(2010) Zhao-Li Zhou et al.   Molecular Cancer

Role of themiR-106b-25microRNA cluster in hepatocellular carcinoma

(2009) Yang Li et al.   CANCER SCIENCE

MicroRNAs involved in tumor suppressor and oncogene pathways: Implications for hepatobiliary neoplasia

(2009) Justin L. Mott   HEPATOLOGY

Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA

(2009) S. Vispe et al.   MOLECULAR CANCER THERAPEUTICS

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Causes and consequences of microRNA dysregulation in cancer

(2009) Carlo M. Croce   NATURE REVIEWS GENETICS

Elevated Expression of the miR-17–92 Polycistron and miR-21 in Hepadnavirus-Associated Hepatocellular Carcinoma Contributes to the Malignant Phenotype

(2008) Erin Connolly et al.   AMERICAN JOURNAL OF PATHOLOGY

E2F1-Regulated MicroRNAs Impair TGFβ-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer

(2008) Fabio Petrocca et al.   CANCER CELL

Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer

(2008) Stefano Cairo et al.   CANCER CELL

Emerging Role of miR-106b-25/miR-17-92 Clusters in the Control of Transforming Growth Factor   Signaling

(2008) F. Petrocca et al.   CANCER RESEARCH

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

(2008) Andrea Ventura et al.   CELL