Lgr5+ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis

Spatial heterogeneity in the mammalian liver

(2019) Shani Ben-Moshe et al.   Nature Reviews Gastroenterology & Hepatology

Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes

(2018) Xing Deng et al.   Cell Stem Cell

Development of the liver: Insights into organ and tissue morphogenesis

(2018) Elke A. Ober et al.   JOURNAL OF HEPATOLOGY

Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury

(2018) Shengda Lin et al.   NATURE

Glucagon contributes to liver zonation

(2018) Xiping Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

(2018) Keren Bahar Halpern et al.   NATURE BIOTECHNOLOGY

Metabolic Remodeling during Liver Regeneration

(2018) Matias J. Caldez et al.   DEVELOPMENTAL CELL

Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury

(2017) Wanlu Cao et al.   GASTROENTEROLOGY

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

(2017) Daniela Sia et al.   GASTROENTEROLOGY

Genetic tracing of hepatocytes in liver homeostasis, injury, and regeneration

(2017) Yue Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification

(2017) Julien Calderaro et al.   JOURNAL OF HEPATOLOGY

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

(2017) Alexander Raven et al.   NATURE

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive

(2017) Nai Yang Fu et al.   NATURE CELL BIOLOGY

Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach

(2017) Marc Leushacke et al.   NATURE CELL BIOLOGY

Enhancing the precision of genetic lineage tracing using dual recombinases

(2017) Lingjuan He et al.   NATURE MEDICINE

Animal models as a tool in hepatocellular carcinoma research: A Review

(2017) Nuno Paula Santos et al.   TUMOR BIOLOGY

HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells

(2017) Yuan Lin et al.   Nature Communications

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

(2016) Lara Planas-Paz et al.   NATURE CELL BIOLOGY

Stem cells versus plasticity in liver and pancreas regeneration

(2016) Janel L. Kopp et al.   NATURE CELL BIOLOGY

Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration

(2016) Wenjuan Pu et al.   Nature Communications

Differential reactivation of fetal/neonatal genes in mouse liver tumors induced in cirrhotic and non-cirrhotic conditions

(2015) Xi Chen et al.   CANCER SCIENCE

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

(2015) Joan Font-Burgada et al.   CELL

Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis

(2015) Judit López-Luque et al.   HEPATOLOGY

EGFR Signaling in Liver Diseases

(2015) Karin Komposch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment

(2015) Xueru Mu et al.   JOURNAL OF CLINICAL INVESTIGATION

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

Hepatic progenitor cells of biliary origin with liver repopulation capacity

(2015) Wei-Yu Lu et al.   NATURE CELL BIOLOGY

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

(2014) Kilangsungla Yanger et al.   Cell Stem Cell

Stem/Progenitor Cells in Liver Development, Homeostasis, Regeneration, and Reprogramming

(2014) Atsushi Miyajima et al.   Cell Stem Cell

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

(2014) Branden D. Tarlow et al.   Cell Stem Cell

In situ identification of bipotent stem cells in the mammary gland

(2014) Anne C. Rios et al.   NATURE

EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation

(2014) Hanane Lanaya et al.   NATURE CELL BIOLOGY

Liver zonation: Novel aspects of its regulation and its impact on homeostasis

(2014) Rolf Gebhardt   WORLD JOURNAL OF GASTROENTEROLOGY

Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury

(2014) Johanna R. Schaub et al.   Cell Reports

Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling

(2013) Guobin He et al.   CELL

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration

(2012) Yuichiro Miyaoka et al.   CURRENT BIOLOGY

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

(2011) Yann Malato et al.   JOURNAL OF CLINICAL INVESTIGATION

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

(2010) S. Hoehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice

(2008) Claudia Mitchell et al.   Nature Protocols

Genetic lineage tracing defines distinct neurogenic and gliogenic stages of ventral telencephalic radial glial development

(2008) Todd E Anthony et al.   Neural Development