Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation

Uniform Widespread Nuclear Phosphorylation of Histone H2AX Is an Indicator of Lethal DNA Replication Stress

(2019) Eric Moeglin et al.   Cancers

Antimicrobial Peptide TP4 Induces ROS-Mediated Necrosis by Triggering Mitochondrial Dysfunction in Wild-Type and Mutant p53 Glioblastoma Cells

(2019) Bor-Chyuan Su et al.   Cancers

Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis

(2019) Urbain Weyemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells

(2019) Silvia Magalhães-Novais et al.   Autophagy

Phosphorylation of SOCS1 inhibits the SOCS1-p53 tumor suppressor axis

(2019) Emmanuelle Saint-Germain et al.   CANCER RESEARCH

Repurposing the Electron Transfer Reactant Phenazine Methosulfate (PMS) for the Apoptotic Elimination of Malignant Melanoma Cells through Induction of Lethal Oxidative and Mitochondriotoxic Stress

(2019) Anh B. Hua et al.   Cancers

Impact of ROS Generated by Chemical, Physical, and Plasma Techniques on Cancer Attenuation

(2019) Sarmistha Mitra et al.   Cancers

Evaluation of the inhibition risk of shikonin on human and rat UDP-glucuronosyltransferases (UGT) through the cocktail approach

(2019) Yi Cheng et al.   TOXICOLOGY LETTERS

Adjuvant therapy in colon cancer: less is more

(2018) David H Ilson   LANCET ONCOLOGY

Short vs long course adjuvant chemotherapy for colon cancer

(2018) Ashray Gunjur   LANCET ONCOLOGY

Anticancer Efficacy of Targeted Shikonin Liposomes Modified with RGD in Breast Cancer Cells

(2018) Xianchun Wen et al.   MOLECULES

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia

(2018) John Anto Pulikkan et al.   CELL

Ipatasertib, a novel Akt inhibitor, induces transcription factor FoxO3a and NF-κB directly regulates PUMA-dependent apoptosis

(2018) Li Sun et al.   Cell Death & Disease

Cytotoxicity and antigenotoxicity evaluation of acetylshikonin and shikonin

(2018) Ramona Figat et al.   DRUG AND CHEMICAL TOXICOLOGY

Effects of ebv-miR-BART7 on tumorigenicity, metastasis, and TRAIL sensitivity of non-small cell lung cancer

(2018) Lei Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Downregulation of TRAIL-Receptor 1 Increases TGFβ Type II Receptor Expression and TGFβ Signalling Via MicroRNA-370-3p in Pancreatic Cancer Cells

(2018) David Radke et al.   Cancers

Identification of Onosma visianii Roots Extract and Purified Shikonin Derivatives as Potential Acaricidal Agents against Tetranychus urticae

(2017) Stefania Sut et al.   MOLECULES

Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells

(2017) See-Hyoung Park et al.   PHYTOMEDICINE

Acetylshikonin inhibits growth of oral squamous cell carcinoma by inducing apoptosis

(2016) Da Jeong Kim et al.   ARCHIVES OF ORAL BIOLOGY

Shikonin Inhibits the Proliferation of Human Breast Cancer Cells by Reducing Tumor-Derived Exosomes

(2016) Yao Wei et al.   MOLECULES

Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery

(2016) Xinyi Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy

(2015) Ming Hong et al.   Cancers

Exploring better strategies for EGFR antibodies in colon cancer

(2014) Andrés Cervantes   LANCET ONCOLOGY

Acetylshikonin, a Novel AChE Inhibitor, Inhibits Apoptosis via Upregulation of Heme Oxygenase-1 Expression in SH-SY5Y Cells

(2013) Yan Wang et al.   Evidence-based Complementary and Alternative Medicine

Pharmacological Properties of Shikonin – A Review of Literature since 2002

(2013) Isabel Andújar et al.   PLANTA MEDICA

Programmed elimination of cells by caspase-independent cell extrusion in C. elegans

(2012) Daniel P. Denning et al.   NATURE

ABT-263 sensitizes TRAIL-resistant hepatocarcinoma cells by downregulating the Bcl-2 family of anti-apoptotic protein

(2011) Guan Wang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

In vitro and in vivo antitumor effects of acetylshikonin isolated from Arnebia euchroma (Royle) Johnst (Ruanzicao) cell suspension cultures

(2009) Wenbi Xiong et al.   Chinese Medicine

Modulation of Orphan Nuclear Receptor Nur77-Mediated Apoptotic Pathway by Acetylshikonin and Analogues

(2008) Jie Liu et al.   CANCER RESEARCH