IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice

IL-6 pathway in the liver: From physiopathology to therapy

(2016) Dirk Schmidt-Arras et al.   JOURNAL OF HEPATOLOGY

Recombinant soluble gp130 protein reduces DEN-induced primary hepatocellular carcinoma in mice

(2016) Jing Hong et al.   Scientific Reports

Regulation of the p53 response and its relationship to cancer

(2015) David W. Meek   BIOCHEMICAL JOURNAL

Macrophages Regulate the Systemic Response to DNA Damage by a Cell Nonautonomous Mechanism

(2015) A. Geiger-Maor et al.   CANCER RESEARCH

Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance

(2015) Michael J. Kraakman et al.   Cell Metabolism

Cre-ativity in the liver: Transgenic approaches to targeting hepatic nonparenchymal cells

(2015) Stephen N. Greenhalgh et al.   HEPATOLOGY

A gp130–Src–YAP module links inflammation to epithelial regeneration

(2015) Koji Taniguchi et al.   NATURE

Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways

(2015) Zhiyang Chen et al.   Nature Communications

Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis

(2015) Bingning Dong et al.   Nature Communications

Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer

(2014) Krasimira Aleksandrova et al.   HEPATOLOGY

Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice

(2014) Clare L. Abram et al.   JOURNAL OF IMMUNOLOGICAL METHODS

EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation

(2014) Hanane Lanaya et al.   NATURE CELL BIOLOGY

IL-6 biology: implications for clinical targeting in rheumatic disease

(2014) Leonard H. Calabrese et al.   Nature Reviews Rheumatology

Incomplete Deletion of IL-4Rα by LysMCre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis

(2014) Kevin M. Vannella et al.   PLoS Pathogens

Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer

(2012) Zhaoyu Li et al.   CELL

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

IL-6 Controls the Innate Immune Response against Listeria monocytogenes via Classical IL-6 Signaling

(2012) J. Hoge et al.   JOURNAL OF IMMUNOLOGY

CRIg mediates early Kupffer cell responses to adenovirus

(2012) J. Q. He et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Medical therapies for hepatocellular carcinoma: a critical view of the evidence

(2012) Augusto Villanueva et al.   Nature Reviews Gastroenterology & Hepatology

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

HCC and angiogenesis: possible targets and future directions

(2011) Andrew X. Zhu et al.   Nature Reviews Clinical Oncology

Role of IL-6 trans-signaling in CCl4 induced liver damage

(2010) Jessica Gewiese-Rabsch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by γ-secretase

(2009) Athena Chalaris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity

(2009) Hua Wang et al.   HEPATOLOGY

SOCS1 Links Cytokine Signaling to p53 and Senescence

(2009) Viviane Calabrese et al.   MOLECULAR CELL

Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer

(2008) Stefano Cairo et al.   CANCER CELL