SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

(2016) Delphine Benarroch-Popivker et al.   MOLECULAR CELL

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

(2015) Michele Cea et al.   BLOOD

Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites

(2015) Gladys Mae Saquilabon Cruz et al.   NUCLEIC ACIDS RESEARCH

The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres

(2014) Adélaïde Saint-Léger et al.   CELL CYCLE

Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3

(2014) Carole Beck et al.   EXPERIMENTAL CELL RESEARCH

Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells

(2014) Yun Bai et al.   GLIA

Transcriptional outcome of telomere signalling

(2014) Jing Ye et al.   NATURE REVIEWS GENETICS

TRF2-Mediated Stabilization of hREST4 Is Critical for the Differentiation and Maintenance of Neural Progenitors

(2014) Patrick Ovando-Roche et al.   STEM CELLS

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Telomeric Protein TRF2 Regulates Angiogenesis by Binding and Activating the PDGFRβ Promoter

(2014) Mounir El Maï et al.   Cell Reports

A novel pathway links telomeres to NK-cell activity

(2014) Julien Cherfils-Vicini et al.   OncoImmunology

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

(2013) Ylli Doksani et al.   CELL

Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway

(2013) Irmina Diala et al.   EMBO REPORTS

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond

(2013) Nicola J. Curtin et al.   MOLECULAR ASPECTS OF MEDICINE

SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

(2013) Debra Toiber et al.   MOLECULAR CELL

A two-step mechanism for TRF2-mediated chromosome-end protection

(2013) Keiji Okamoto et al.   NATURE

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

(2013) Annamaria Biroccio et al.   NATURE CELL BIOLOGY

p300-mediated acetylation of TRF2 is required for maintaining functional telomeres

(2013) Yoon Ra Her et al.   NUCLEIC ACIDS RESEARCH

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

(2013) E. Salvati et al.   NUCLEIC ACIDS RESEARCH

Telomeric impact of conventional chemotherapy

(2013) Yiming Lu et al.   Frontiers of Medicine

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging

(2012) Gaoxiang Jia et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

(2011) Bo Yang et al.   CELL CYCLE

The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats

(2011) Thomas Simonet et al.   CELL RESEARCH

Human telomeric proteins occupy selective interstitial sites

(2011) Dong Yang et al.   CELL RESEARCH

The N-terminal domains of TRF1 and TRF2 regulate their ability to condense telomeric DNA

(2011) Anaïs Poulet et al.   NUCLEIC ACIDS RESEARCH

Nontelomeric splice variant of telomere repeat-binding factor 2 maintains neuronal traits by sequestering repressor element 1-silencing transcription factor

(2011) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

SIRT6 is required for maintenance of telomere position effect in human cells

(2011) Ruth I. Tennen et al.   Nature Communications

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

(2010) Jing Ye et al.   CELL

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence

(2010) Kaori Fujita et al.   NATURE CELL BIOLOGY

Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation

(2010) Abderrahmane Kaidi et al.   SCIENCE

The Shelterin Protein TRF2 Inhibits Chk2 Activity at Telomeres in the Absence of DNA Damage

(2009) Giacomo Buscemi et al.   CURRENT BIOLOGY

TRF2 promotes, remodels and protects telomeric Holliday junctions

(2009) Anaïs Poulet et al.   EMBO JOURNAL

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

DNA Damage-Induced Phosphorylation of TRF2 Is Required for the Fast Pathway of DNA Double-Strand Break Repair

(2009) N. Huda et al.   MOLECULAR AND CELLULAR BIOLOGY

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs

(2009) Hyeung Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nontelomeric TRF2-REST Interaction Modulates Neuronal Gene Silencing and Fate of Tumor and Stem Cells

(2008) Peisu Zhang et al.   CURRENT BIOLOGY

PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA

(2008) Kazuto Sugimura et al.   JOURNAL OF CELL BIOLOGY

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

The Identification of Zebrafish Mutants Showing Alterations in Senescence-Associated Biomarkers

(2008) Shuji Kishi et al.   PLoS Genetics