ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53

p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) inhibits amyloid aggregation of mutant p53 in cancer cells

(2019) Luciana P. Rangel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages

(2018) Jared P. Taylor et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibition of HIV early replication by the p53 and its downstream gene p21

(2018) Binshan Shi et al.   Virology Journal

USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1

(2018) Edmund Osei Kuffour et al.   JOURNAL OF VIROLOGY

p53 Isoforms and Their Implications in Cancer

(2018) Maximilian Vieler et al.   Cancers

A Mass Spectrometry-Based Profiling of Interactomes of Viral DDB1- and Cullin Ubiquitin Ligase-Binding Proteins Reveals NF-κB Inhibitory Activity of the HIV-2-Encoded Vpx

(2018) Christine D. Landsberg et al.   Frontiers in Immunology

ISGylation – a key to lock the cell gates for preventing the spread of threats

(2017) Carolina Villarroya-Beltri et al.   JOURNAL OF CELL SCIENCE

p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity

(2017) Jose Carlos Valle-Casuso et al.   JOURNAL OF VIROLOGY

p21: A Two-Faced Genome Guardian

(2017) Alexandros G. Georgakilas et al.   TRENDS IN MOLECULAR MEDICINE

The impact of p53 on the early stage replication of retrovirus

(2017) Michaela Kinnetz et al.   Virology Journal

Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?

(2017) Rebecca P. Sumner et al.   Frontiers in Immunology

Atorvastatin restricts HIV replication in CD4+ T cells by upregulation of p21

(2016) Shokrollah Elahi et al.   AIDS

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

(2016) Andreas C. Joerger et al.   Annual Review of Biochemistry

p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy

(2016) Wafik S. El-Deiry   CANCER RESEARCH

Cancer‐specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis

(2016) Marco M Candeias et al.   EMBO REPORTS

ISG15 expression correlates with HIV-1 viral load and with factors regulating T cell response

(2016) Carolina Scagnolari et al.   IMMUNOBIOLOGY

Multiple functions of USP18

(2016) Nadine Honke et al.   Cell Death & Disease

Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification

(2016) Jong Ho Park et al.   Nature Communications

The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells

(2016) Roger Badia et al.   PLoS Pathogens

p53-Derived Host Restriction of HIV-1 Replication by Protein Kinase R-Mediated Tat Phosphorylation and Inactivation

(2015) Cheol-Hee Yoon et al.   JOURNAL OF VIROLOGY

Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining

(2015) Wenxia Jiang et al.   MOLECULAR CELL

Innate immunity against HIV-1 infection

(2015) Marcus Altfeld et al.   NATURE IMMUNOLOGY

HIV-1 and interferons: who's interfering with whom?

(2015) Tomas Doyle et al.   NATURE REVIEWS MICROBIOLOGY

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance

(2015) Lars Ketscher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of murine SAMHD1 regulates its antiretroviral activity

(2015) Sabine Wittmann et al.   Retrovirology

SAMHD1: At the Crossroads of Cell Proliferation, Immune Responses, and Virus Restriction

(2015) Ester Ballana et al.   TRENDS IN MICROBIOLOGY

Innate immune sensing of HIV-1 infection

(2015) Martin R. Jakobsen et al.   Current Opinion in HIV and AIDS

Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction

(2015) Laurence H. Arnold et al.   PLoS Pathogens

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

p53 vs. ISG15: Stop, you’re killing me

(2014) Carl W. Anderson   CELL CYCLE

Isg15 controls p53 stability and functions

(2014) Yi-Fu Huang et al.   CELL CYCLE

A Cell-Intrinsic Inhibitor of HIV-1 Reverse Transcription in CD4+ T Cells from Elite Controllers

(2014) Jin Leng et al.   Cell Host & Microbe

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

(2014) Xianqin Zhang et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

The aggregation of mutant p53 produces prion-like properties in cancer

(2014) Luciana P Rangel et al.   Prion

p21 regulates the HIV-1 restriction factor SAMHD1

(2014) E. Pauls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion-like aggregation of mutant p53 in cancer

(2014) Jerson L. Silva et al.   TRENDS IN BIOCHEMICAL SCIENCES

Beyond DNA Repair: DNA-PK Function in Cancer

(2014) J. F. Goodwin et al.   Cancer Discovery

Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53

(2013) Hind Hafsi et al.   BMC CANCER

The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation

(2013) Tommy E. White et al.   Cell Host & Microbe

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10

(2013) Christoph Burkart et al.   EMBO Molecular Medicine

SAMHD1 Host Restriction Factor: A Link with Innate Immune Sensing of Retrovirus Infection

(2013) Alexandre Sze et al.   JOURNAL OF MOLECULAR BIOLOGY

Innate Antiviral Immune Signaling, Viral Evasion and Modulation by HIV-1

(2013) Arjun Rustagi et al.   JOURNAL OF MOLECULAR BIOLOGY

HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration

(2013) Arik Cooper et al.   NATURE

p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway

(2013) A. Allouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

C/EBPα Induces Highly Efficient Macrophage Transdifferentiation of B Lymphoma and Leukemia Cell Lines and Impairs Their Tumorigenicity

(2013) Francesca Rapino et al.   Cell Reports

Phosphorylation of SAMHD1 by Cyclin A2/CDK1 Regulates Its Restriction Activity toward HIV-1

(2013) Alexandra Cribier et al.   Cell Reports

p53 Ser15phosphorylation disrupts the p53–RPA70 complex and induces RPA70-mediated DNA repair in hypoxia

(2012) Esha Madan et al.   BIOCHEMICAL JOURNAL

Caught in translation: innate restriction of HIV mRNA translation by a schlafen family protein

(2012) Martin R Jakobsen et al.   CELL RESEARCH

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils

(2012) Ana P. D. Ano Bom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

(2012) Hanna-Mari Baldauf et al.   NATURE MEDICINE

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+ T-cells

(2012) Benjamin Descours et al.   Retrovirology

Two Independent Mechanisms Promote Expression of an N-terminal Truncated USP18 Isoform with Higher DeISGylation Activity in the Nucleus

(2011) Christoph Burkart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21

(2011) Huabiao Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanism of Inhibition of Retrovirus Release from Cells by Interferon-Induced Gene ISG15

(2011) Z. Kuang et al.   JOURNAL OF VIROLOGY

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

(2011) Nadine Honke et al.   NATURE IMMUNOLOGY

CD169+ macrophages take the bullet

(2011) Burkhard Ludewig et al.   NATURE IMMUNOLOGY

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

(2011) Véronique François-Newton et al.   PLoS One

ISG15 and immune diseases

(2010) Young Joo Jeon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Emerging Role of ISG15 in Antiviral Immunity

(2010) Brian Skaug et al.   CELL

Examination of the expanding pathways for the regulation of p21 expression and activity

(2010) Yong-Sam Jung et al.   CELLULAR SIGNALLING

p53 at a glance

(2010) C. A. Brady et al.   JOURNAL OF CELL SCIENCE

The Interferon-Induced Gene ISG15 Blocks Retrovirus Release from Cells Late in the Budding Process

(2010) A. Pincetic et al.   JOURNAL OF VIROLOGY

Innate immune recognition and activation during HIV infection

(2010) Trine H Mogensen et al.   Retrovirology

Antiviral Properties of ISG15

(2010) Deborah J. Lenschow   Viruses-Basel

p21waf1/CIP1, a CDK inhibitor and a negative feedback system that controls macrophage activation

(2009) Jorge Lloberas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Approaching the Asymptote: 20 Years Later

(2009) Ruslan Medzhitov   IMMUNITY

Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes

(2009) Elsa Callén et al.   MOLECULAR CELL

Microarray study reveals that HIV-1 induces rapid type-I interferon-dependent p53 mRNA up-regulation in human primary CD4+ T cells

(2009) Michaël Imbeault et al.   Retrovirology