The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives

Sphingolipids in Alzheimer's disease, how can we target them?

(2020) Simone M. Crivelli et al.   ADVANCED DRUG DELIVERY REVIEWS

Protein transmission in neurodegenerative disease

(2020) Chao Peng et al.   Nature Reviews Neurology

Severe COVID-19 infection in a patient with multiple sclerosis treated with fingolimod

(2020) Christian Foerch et al.   Multiple Sclerosis and Related Disorders

New insights into functions of the sphingosine-1-phosphate transporter SPNS2

(2019) Sarah Spiegel et al.   JOURNAL OF LIPID RESEARCH

Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter

(2019) Taketoshi Kajimoto et al.   Science Signaling

Sphk1/S1P/S1PR1 Signaling is Involved in the Development of Autoimmune Thyroiditis in Patients and NOD.H-2h4 Mice

(2019) Cheng Han et al.   THYROID

S1P1 Regulates M1/M2 Polarization toward Brain Injury after Transient Focal Cerebral Ischemia

(2019) Bhakta Prasad Gaire et al.   Biomolecules & Therapeutics

Neural sphingosine 1-phosphate accumulation activates microglia and links impaired autophagy and inflammation

(2019) Indulekha Karunakaran et al.   GLIA

Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin

(2019) Brian J. Laidlaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes

(2019) Yu Hisano et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of Patients with Ulcerative Colitis

(2019) William J. Sandborn et al.   GASTROENTEROLOGY

Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

(2019) Andreane Cartier et al.   SCIENCE

LIPID RAFTS AND NEURODEGENERATION: Structural and functional roles in physiologic aging and neurodegenerative diseases

(2019) Sara Grassi et al.   JOURNAL OF LIPID RESEARCH

Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh T cells

(2019) Kyoko Shimano et al.   PLoS One

Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2

(2018) Yingbao Wang et al.   CIRCULATION

MicroRNA-149-5p regulates blood–brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes

(2018) Yan Wan et al.   FASEB JOURNAL

The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo

(2018) Lu Dai et al.   INTERNATIONAL JOURNAL OF CANCER

Biased signalling: from simple switches to allosteric microprocessors

(2018) Jeffrey S. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Ozanimod (RPC1063), a selective S1PR1 and S1PR5 modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus

(2018) Kristen R. Taylor Meadows et al.   PLoS One

The S1P Axis: New Exciting Route for Treating Huntington’s Disease

(2018) Alba Di Pardo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sphingolipid Metabolism Is Dysregulated at Transcriptomic and Metabolic Levels in the Spinal Cord of an Animal Model of Amyotrophic Lateral Sclerosis

(2018) Alexandre Henriques et al.   Frontiers in Molecular Neuroscience

Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain

(2018) Gaëlle Dominguez et al.   Acta Neuropathologica Communications

Increased Ceramide in Brains with Alzheimer's and Other Neurodegenerative Diseases

(2018) Valery Filippov et al.   JOURNAL OF ALZHEIMERS DISEASE

Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo

(2018) R. D. W. Kelly et al.   Scientific Reports

Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization

(2018) Bhakta Prasad Gaire et al.   Journal of Neuroinflammation

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

Sphingosine 1-Phosphate (S1P) Signaling in Glioblastoma Multiforme—A Systematic Review

(2017) Shailaja Mahajan-Thakur et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rationale and design of combination of an immune modulator Fingolimod with Alteplase bridging with Mechanical Thrombectomy in Acute Ischemic Stroke (FAMTAIS) trial

(2017) Sheng Zhang et al.   International Journal of Stroke

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases

(2017) Haruto Kurata et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes

(2017) Stephanie S. Dusaban et al.   Journal of Neuroinflammation

Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease

(2017) Yumiko V. Taguchi et al.   JOURNAL OF NEUROSCIENCE

Identification of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P1) as a Pathogenic Factor in Transient Focal Cerebral Ischemia

(2017) Bhakta Prasad Gaire et al.   MOLECULAR NEUROBIOLOGY

Two-year results from a phase 2 extension study of oral amiselimod in relapsing multiple sclerosis

(2017) Ludwig Kappos et al.   Multiple Sclerosis Journal

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

(2017) Kassandra Kisler et al.   NATURE REVIEWS NEUROSCIENCE

An engineered S1P chaperone attenuates hypertension and ischemic injury

(2017) Steven L. Swendeman et al.   Science Signaling

Bioluminescence imaging of G protein-coupled receptor activation in living mice

(2017) Mari Kono et al.   Nature Communications

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements

(2017) Leila Pirhaji et al.   Nature Communications

The sphingosine kinase 2 inhibitor ABC294640 inhibits cervical carcinoma cell growth

(2017) Ling Xu et al.   Oncotarget

Two-year results from a phase 2 extension study of oral amiselimod in relapsing multiple sclerosis

(2017) Ludwig Kappos et al.   Multiple Sclerosis Journal

An engineered S1P chaperone attenuates hypertension and ischemic injury

(2017) Steven L. Swendeman et al.   Science Signaling

Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study

(2017) Katrin G. Schmidt et al.   Frontiers in Immunology

Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease

(2017) Alba Di Pardo et al.   Scientific Reports

DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling

(2017) Shaymaa Mohamed Mohamed Badawy et al.   Scientific Reports

S1P1 deletion differentially affects TH17 and Regulatory T cells

(2017) Ahmet Eken et al.   Scientific Reports

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

(2016) Amy R. Nelson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

Fingolimod (FTY720) improves hippocampal synaptic plasticity and memory deficit in rats following focal cerebral ischemia

(2016) Maryam Nazari et al.   BRAIN RESEARCH BULLETIN

Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk

(2016) Kunio Sugahara et al.   BRITISH JOURNAL OF PHARMACOLOGY

A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma

(2016) Sumanta K. Pal et al.   CANCER

Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer';s Disease

(2016) Sankha Shubhra Chakrabarti et al.   Current Alzheimer Research

Sphingosine-1-Phosphate Signaling in Endothelial Disorders

(2016) Teresa Sanchez   Current Atherosclerosis Reports

Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion

(2016) Manhua Lv et al.   INFLAMMATION RESEARCH

Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study

(2016) Zoe Arvanitakis et al.   LANCET NEUROLOGY

Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis

(2016) Rosa Luisa Potenza et al.   Neurotherapeutics

Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice

(2016) Vanessa H. Brait et al.   STROKE

Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials

(2016) T. G. Murali Dhar et al.   ACS Medicinal Chemistry Letters

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

(2016) Megan M. Young et al.   Cell Reports

Huntington’s Disease: Mechanisms of Pathogenesis and Therapeutic Strategies

(2016) Maria Jimenez-Sanchez et al.   Cold Spring Harbor Perspectives in Medicine

Fingolimod-induced leukoencephalopathy in a patient with neuromyelitis optica spectrum disorder

(2016) Fumihito Yoshii et al.   Multiple Sclerosis and Related Disorders

Ponesimod, a selective S1P1 receptor modulator: a potential treatment for multiple sclerosis and other immune-mediated diseases

(2016) Daniele D’Ambrosio et al.   Therapeutic Advances in Chronic Disease

Combination of the Immune Modulator Fingolimod With Alteplase in Acute Ischemic StrokeCLINICAL PERSPECTIVE

(2015) Zilong Zhu et al.   CIRCULATION

Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia

(2015) Shuli Zheng et al.   EXPERIMENTAL NEUROLOGY

Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis

(2015) Kate A. Parham et al.   FASEB JOURNAL

Cerebrospinal Fluid Biomarkers of Neurovascular Dysfunction in Mild Dementia and Alzheimer'S Disease

(2015) Melanie D Sweeney et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

(2015) Richard L. Proia et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo

(2015) Cai Xun et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Acid Sphingomyelinase–Derived Ceramide Regulates ICAM-1 Function during T Cell Transmigration across Brain Endothelial Cells

(2015) Melissa A. Lopes Pinheiro et al.   JOURNAL OF IMMUNOLOGY

Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling

(2015) Eunjung Moon et al.   MEDIATORS OF INFLAMMATION

Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure

(2015) Anna Cantalupo et al.   NATURE MEDICINE

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

(2015) Shanmugam Panneer Selvam et al.   Science Signaling

Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage

(2015) Kenji Yagi et al.   STROKE

Ceramides – Lipotoxic Inducers of Metabolic Disorders

(2015) Bhagirath Chaurasia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke

(2015) Gab Seok Kim et al.   Nature Communications

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

(2015) Nima Etemadi et al.   eLife

Varicella-Zoster Virus Infections in Patients Treated With Fingolimod

(2015) Ann M. Arvin et al.   JAMA Neurology

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

(2015) Shanmugam Panneer Selvam et al.   Science Signaling

AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis

(2015) Devadoss J. Samuvel et al.   PLoS One

STAT3 in Epithelial Cells Regulates Inflammation and Tumor Progression to Malignant State in Colon

(2015) Andrew V. Nguyen et al.   NEOPLASIA

Cardiac and vascular effects of fingolimod: Mechanistic basis and clinical implications

(2014) John Camm et al.   AMERICAN HEART JOURNAL

Alpha-synuclein degradation by autophagic pathways: A potential key to Parkinson’s Disease pathogenesis

(2014) Maria Xilouri et al.   Autophagy

Hashimoto’s Encephalopathy: A Brief Review

(2014) Howard S. Kirshner   Current Neurology and Neuroscience Reports

Original article The key role of sphingosine kinases in the molecular mechanism of neuronal cell survival and death in an experimental model of Parkinson’s disease

(2014) Joanna A. Pyszko et al.   FOLIA NEUROPATHOLOGICA

Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo

(2014) Mari Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility

(2014) Lillian Cruz-Orengo et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamin 2–dependent endocytosis is required for sustained S1PR1 signaling

(2014) Tim Willinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An update on the biology of sphingosine 1-phosphate receptors

(2014) Victoria A. Blaho et al.   JOURNAL OF LIPID RESEARCH

Multiple sphingolipid abnormalities following cerebral microendothelial hypoxia

(2014) Fernando D. Testai et al.   JOURNAL OF NEUROCHEMISTRY

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5

(2014) Kuzhuvelil B Harikumar et al.   NATURE IMMUNOLOGY

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells

(2014) Shereen Jamaladdin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of an immune modulator fingolimod on acute ischemic stroke

(2014) Ying Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity

(2014) Anissa Kempf et al.   PLOS BIOLOGY

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

(2014) Timothy A Couttas et al.   Acta Neuropathologica Communications

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease

(2014) Johnatan Ceccom et al.   Acta Neuropathologica Communications

Sphingosine-1-Phosphate and Its Receptors: Structure, Signaling, and Influence

(2013) Hugh Rosen et al.   Annual Review of Biochemistry

Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M

(2013) Makoto Kurano et al.   ATHEROSCLEROSIS

Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies

(2013) Claudia Manzoni et al.   FASEB JOURNAL

Hepatic Apolipoprotein M (ApoM) Overexpression Stimulates Formation of Larger ApoM/Sphingosine 1-Phosphate-enriched Plasma High Density Lipoprotein

(2013) Mingxia Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Metabolic Shift Favoring Sphingosine 1-Phosphate at the Expense of Ceramide Controls Glioblastoma Angiogenesis

(2013) Hazem J. Abuhusain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

(2013) Kate S. Smigiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lysosomal impairment in Parkinson's disease

(2013) Benjamin Dehay et al.   MOVEMENT DISORDERS

Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

(2013) Gregory T. Kunkel et al.   NATURE REVIEWS DRUG DISCOVERY

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Characteristic Cerebrospinal Fluid Cytokine/Chemokine Profiles in Neuromyelitis Optica, Relapsing Remitting or Primary Progressive Multiple Sclerosis

(2013) Takuya Matsushita et al.   PLoS One

Moesin Controls Clathrin-Mediated S1PR1 Internalization in T Cells

(2013) Akira Nomachi et al.   PLoS One

Sphingosine-1-phosphate receptor-2 mediated NFκB activation contributes to tumor necrosis factor-α induced VCAM-1 and ICAM-1 expression in endothelial cells

(2013) Wenliang Zhang et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Fingolimod Reduces Hemorrhagic Transformation Associated With Delayed Tissue Plasminogen Activator Treatment in a Mouse Thromboembolic Model

(2013) Francisco Campos et al.   STROKE

FTY720 Ameliorates Acute Ischemic Stroke in Mice by Reducing Thrombo-Inflammation but Not by Direct Neuroprotection

(2013) Peter Kraft et al.   STROKE

Novel Sphingosine-1-Phosphate Receptor Modulator KRP203 Combined With Locally Delivered Regulatory T Cells Induces Permanent Acceptance of Pancreatic Islet Allografts

(2013) Mithun Khattar et al.   TRANSPLANTATION

Clinical and multimodal biomarker correlates of ADNI neuropathological findings

(2013) Jon B Toledo et al.   Acta Neuropathologica Communications

Fingolimod attenuates ceramide-induced blood–brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes

(2012) Ruben van Doorn et al.   ACTA NEUROPATHOLOGICA

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Novel small-molecular therapeutics for rheumatoid arthritis

(2012) Roy Fleischmann   CURRENT OPINION IN RHEUMATOLOGY

Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage

(2012) William B. Rolland et al.   EXPERIMENTAL NEUROLOGY

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

(2012) Shigetomo Fukuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway

(2012) Bradley K. Wacker et al.   JOURNAL OF NEUROCHEMISTRY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

The link between the GBA gene and parkinsonism

(2012) Ellen Sidransky et al.   LANCET NEUROLOGY

The Sjögren-Larsson Syndrome Gene Encodes a Hexadecenal Dehydrogenase of the Sphingosine 1-Phosphate Degradation Pathway

(2012) Kanae Nakahara et al.   MOLECULAR CELL

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

Sphingolipids: Critical players in Alzheimer’s disease

(2012) Gerhild van Echten-Deckert et al.   PROGRESS IN LIPID RESEARCH

Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of  -Amyloid in TH1 and TH17 Versions of Experimental Autoimmune Encephalomyelitis

(2012) J. L. Grant et al.   Science Translational Medicine

Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia

(2011) Waltraud Pfeilschifter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

(2011) Arthur Liesz et al.   BRAIN

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

RACK1, A multifaceted scaffolding protein: Structure and function

(2011) David R Adams et al.   Cell Communication and Signaling

A Phase I Clinical Trial of Safingol in Combination with Cisplatin in Advanced Solid Tumors

(2011) M. A. Dickson et al.   CLINICAL CANCER RESEARCH

Sphingosine-1-phospate receptor 4 (S1P4) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model

(2011) Tobias Schulze et al.   FASEB JOURNAL

Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

(2011) Elaine Studer et al.   HEPATOLOGY

Engagement of S1P1-degradative mechanisms leads to vascular leak in mice

(2011) Myat Lin Oo et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder

(2011) Ju-Hong Min et al.   Multiple Sclerosis Journal

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Sphingosine Kinase 1 and Sphingosine 1-Phosphate Receptor 3 Are Functionally Upregulated on Astrocytes under Pro-Inflammatory Conditions

(2011) Iris Fischer et al.   PLoS One

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

(2011) C. Christoffersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid composition influences the release of Alzheimer's amyloid β-peptide from membranes

(2011) Justin A. Lemkul et al.   PROTEIN SCIENCE

GRK2-Dependent S1PR1 Desensitization Is Required for Lymphocytes to Overcome Their Attraction to Blood

(2011) T. I. Arnon et al.   SCIENCE

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

The role of reactive oxygen species and autophagy in safingol-induced cell death

(2011) L-U Ling et al.   Cell Death & Disease

Fingolimod provides long-term protection in rodent models of cerebral ischemia

(2010) Ying Wei et al.   ANNALS OF NEUROLOGY

FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice

(2010) Seiichiro Ando et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endosome–lysosome fusion: Figure 1

(2010) J. Paul Luzio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction

(2010) H. Nguyen-Jackson et al.   BLOOD

Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation

(2010) C. Kleinschnitz et al.   BLOOD

Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration

(2010) Roger A. Sabbadini   BRITISH JOURNAL OF PHARMACOLOGY

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis in Liver

(2010) Meryem Bektas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics

(2010) Shobha Thangada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

(2010) K. J. French et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Are synucleinopathies prion-like disorders?

(2010) Elodie Angot et al.   LANCET NEUROLOGY

Membranes in Balance: Mechanisms of Sphingolipid Homeostasis

(2010) David K. Breslow et al.   MOLECULAR CELL

Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6

(2010) Akiyuki Uzawa et al.   Multiple Sclerosis Journal

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

(2010) Heehyoung Lee et al.   NATURE MEDICINE

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature

(2010) J. Chun et al.   PHARMACOLOGICAL REVIEWS

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia

(2009) Bozena Czech et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

(2009) Juliane Neumann et al.   BRAIN

PKC Phosphorylation of TRAF2 Mediates IKKα/β Recruitment and K63-Linked Polyubiquitination

(2009) Shitao Li et al.   MOLECULAR CELL

T time in the brain

(2009) Eng H Lo   NATURE MEDICINE

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Neurologic Manifestations of Systemic Lupus Erythematosus in Children and Adults

(2009) Eyal Muscal et al.   NEUROLOGIC CLINICS

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Hypoxic Preconditioning-Induced Cerebral Ischemic Tolerance

(2009) Bradley K. Wacker et al.   STROKE

Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats

(2009) Yu Hasegawa et al.   STROKE

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Glucocerebrosidase Gene Mutations

(2008) Ignacio F. Mata et al.   ARCHIVES OF NEUROLOGY

Glycosphingolipid behaviour in complex membranes

(2008) Alessandro Prinetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Principles of lysosomal membrane degradation

(2008) Heike Schulze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood-Brain-Barrier Damage

(2008) Carolyn A. Foster et al.   BRAIN PATHOLOGY

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

The sphingolipid salvage pathway in ceramide metabolism and signaling

(2008) Kazuyuki Kitatani et al.   CELLULAR SIGNALLING

Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate

(2008) Krishnan Venkataraman et al.   CIRCULATION RESEARCH

Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization

(2008) Sergio Caballero et al.   EXPERIMENTAL EYE RESEARCH

Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease

(2008) Jose Bras et al.   FEBS Journal

Increased survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1-phosphate receptor agonist

(2008) Scott E. Wenderfer et al.   KIDNEY INTERNATIONAL

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation

(2008) Frank Niessen et al.   NATURE

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

Structural Basis of Protein Kinase C Isoform Function

(2008) Susan F. Steinberg   PHYSIOLOGICAL REVIEWS

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY