CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

ICOS Controls the Pool Size of Effector-Memory and Regulatory T Cells

(2014) Y. Burmeister et al.   JOURNAL OF IMMUNOLOGY

IL-2 therapy in type 1 diabetes: “Trials” and tribulations

(2013) S. Alice Long et al.   CLINICAL IMMUNOLOGY

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2

(2013) Jonathan Sitrin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells

(2013) Georg Gasteiger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues

(2013) I. K. Gratz et al.   JOURNAL OF IMMUNOLOGY

IL-2R Signaling Is Essential for Functional Maturation of Regulatory T Cells during Thymic Development

(2013) G. Cheng et al.   JOURNAL OF IMMUNOLOGY

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells

(2013) Wim Pierson et al.   NATURE IMMUNOLOGY

Regulatory T Cells in HIV Infection: Can Immunotherapy Regulate the Regulator?

(2012) Mohammad-Ali Jenabian et al.   Clinical & Developmental Immunology

An N-Terminal Mutation of the Foxp3 Transcription Factor Alleviates Arthritis but Exacerbates Diabetes

(2012) Jaime Darce et al.   IMMUNITY

The Cytokines Interleukin 27 and Interferon-γ Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology

(2012) Aisling O’Hara Hall et al.   IMMUNITY

Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency

(2012) Matthew L. Bettini et al.   IMMUNITY

T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2

(2012) Meghan A. Koch et al.   IMMUNITY

Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity

(2012) Deepali Malhotra et al.   IMMUNOLOGICAL REVIEWS

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

(2012) Mahesh Yadav et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-2 Signals Determine the Degree of TCR Signaling Necessary To Support Regulatory T Cell Proliferation In Vivo

(2012) T. Zou et al.   JOURNAL OF IMMUNOLOGY

CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients

(2012) A. J. Rech et al.   Science Translational Medicine

Differentiation and function of Foxp3+ effector regulatory T cells

(2012) Erika Cretney et al.   TRENDS IN IMMUNOLOGY

Genome-wide association study of rheumatoid arthritis in Koreans: Population-specific loci as well as overlap with European susceptibility loci

(2011) Jan Freudenberg et al.   ARTHRITIS AND RHEUMATISM

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

(2011) Ashutosh Chaudhry et al.   IMMUNITY

T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells

(2011) Guoyan Cheng et al.   IMMUNOLOGICAL REVIEWS

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Response to self antigen imprints regulatory memory in tissues

(2011) Michael D. Rosenblum et al.   NATURE

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

(2011) Erika Cretney et al.   NATURE IMMUNOLOGY

Clinical perspectives for regulatory T cells in transplantation tolerance

(2011) Keli L. Hippen et al.   SEMINARS IN IMMUNOLOGY

CD4+Foxp3+ regulatory T cell therapy in transplantation

(2011) Q. Tang et al.   Journal of Molecular Cell Biology

Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)

(2010) Tyler R Simpson et al.   CURRENT OPINION IN IMMUNOLOGY

Cutting Edge: Mechanisms of IL-2-Dependent Maintenance of Functional Regulatory T Cells

(2010) L. Barron et al.   JOURNAL OF IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Foxo: in command of T lymphocyte homeostasis and tolerance

(2010) Weiming Ouyang et al.   TRENDS IN IMMUNOLOGY

Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

(2009) James L. Riley et al.   IMMUNITY

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

(2009) Guillaume Darrasse-Jèze et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impaired CD4 and CD8 Effector Function and Decreased Memory T Cell Populations in ICOS-Deficient Patients

(2009) N. Takahashi et al.   JOURNAL OF IMMUNOLOGY

Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase

(2009) M. Gigoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-2 and its high-affinity receptor: Genetic control of immunoregulation and autoimmunity

(2009) Jinguo Wang et al.   SEMINARS IN IMMUNOLOGY

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

(2008) Tomoki Ito et al.   IMMUNITY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

Common variants at CD40 and other loci confer risk of rheumatoid arthritis

(2008) Soumya Raychaudhuri et al.   NATURE GENETICS

The Biology of Interleukin-2

(2007) Thomas R. Malek   Annual Review of Immunology