Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration

Antiangiogenic agents and targets: A perspective

(2010) Beverly A. Teicher   BIOCHEMICAL PHARMACOLOGY

The Expression of Sphingosine Kinase-1 in Head and Neck Carcinoma

(2010) María M. Facchinetti et al.   CELLS TISSUES ORGANS

Endothelial Functions of Sphingosine-1-phosphate

(2010) Susann Lucke et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A Novel Sphingosine Kinase Inhibitor Induces Autophagy in Tumor Cells

(2010) V. Beljanski et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells

(2010) J. S. Long et al.   MOLECULAR AND CELLULAR BIOLOGY

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

An update on sphingosine-1-phosphate and other sphingolipid mediators

(2010) Henrik Fyrst et al.   Nature Chemical Biology

INTRAVITREAL BEVACIZUMAB IN VASCULAR PIGMENT EPITHELIUM DETACHMENT AS A RESULT OF SUBFOVEAL OCCULT CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION

(2010) Thomas Ach et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

SphK1 Regulates Proinflammatory Responses Associated with Endotoxin and Polymicrobial Sepsis

(2010) P. Puneet et al.   SCIENCE

Activation of Sphingosine Kinase-1 in Cancer: Implications for Therapeutic Targeting

(2010) Olivier Cuvillier et al.   Current Molecular Pharmacology

Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts

(2009) D. Kapitonov et al.   CANCER RESEARCH

Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor- -stimulated collagen production by cardiac fibroblasts

(2009) N. Gellings Lowe et al.   CARDIOVASCULAR RESEARCH

Regulation of vascular physiology and pathology by the S1P2 receptor subtype

(2009) A. Skoura et al.   CARDIOVASCULAR RESEARCH

S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species

(2009) Noriko Takuwa et al.   CARDIOVASCULAR RESEARCH

Sphingosine Kinase 1 Is Associated with Gastric Cancer Progression and Poor Survival of Patients

(2009) W. Li et al.   CLINICAL CANCER RESEARCH

Sphingosine-1-phosphate effects on the inner wall of Schlemm's canal and outflow facility in perfused human eyes

(2009) W. Daniel Stamer et al.   EXPERIMENTAL EYE RESEARCH

Regulation of macrophage function by sphingosine-1-phosphate

(2009) Andreas Weigert et al.   IMMUNOBIOLOGY

Quantitative analysis of sphingosine-1-phosphate by HPLC after napthalene-2,3-dicarboxaldehyde (NDA) derivatization

(2009) Xingxuan He et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Inhibitory Role of Sphingosine 1-Phosphate Receptor 2 in Macrophage Recruitment during Inflammation

(2009) J. Michaud et al.   JOURNAL OF IMMUNOLOGY

Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies

(2009) Nicole O'Brien et al.   JOURNAL OF LIPID RESEARCH

The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen

(2009) J. M. Wojciak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New intercellular lipid mediators and their GPCRs: An update

(2009) Dong-Soon Im   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration

(2009) DanHong Zhu et al.   VISION RESEARCH

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

(2008) S. W. Paugh et al.   BLOOD

Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1

(2008) X. Li et al.   BLOOD

Resistance to chemotherapy: new treatments and novel insights into an old problem

(2008) S Raguz et al.   BRITISH JOURNAL OF CANCER

Sphingosine Kinase 1: A New Modulator of Hypoxia Inducible Factor 1  during Hypoxia in Human Cancer Cells

(2008) I. Ader et al.   CANCER RESEARCH

Cross-talk between LPA1 and Epidermal Growth Factor Receptors Mediates Up-regulation of Sphingosine Kinase 1 to Promote Gastric Cancer Cell Motility and Invasion

(2008) D. Shida et al.   CANCER RESEARCH

Targeting SphK1 as a New Strategy against Cancer

(2008) Dai Shida et al.   CURRENT DRUG TARGETS

Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye

(2008) James S. Swaney et al.   EXPERIMENTAL EYE RESEARCH

Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization

(2008) Sergio Caballero et al.   EXPERIMENTAL EYE RESEARCH

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal

(2008) David R. Gude et al.   FASEB JOURNAL

RETRACTED: Refining siRNA in vivo transfection: Silencing SPHK1 reveals its key role in C5a-induced inflammation in vivo

(2008) Peter N. Pushparaj et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization

(2008) Bing Xie et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Constitutive activation of c-Jun N-terminal kinase correlates with histologic grade and EGFR expression in diffuse gliomas

(2008) Jian Yi Li et al.   JOURNAL OF NEURO-ONCOLOGY

Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models

(2008) D. Pchejetski et al.   MOLECULAR CANCER THERAPEUTICS